The synthesis of desamido analogs of staurosporine, RK-286c, and TAN-1030a

Tetrahedron Letters

Volumn 37, Issue 41, 1996, Pages 7335-7338

  Wood, John L ^a   Stoltz, Brian M ^a   Onwueme, Kenolisa ^a   Goodman, Steven N ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4' DEMETHYLAMINO 4' HYDROXYSTAUROSPORINE; STAUROSPORINE DERIVATIVE; TAN 1030A; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY; TECHNIQUE;

EID: 0030574007     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01639-5     Document Type: Article

References (18)

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9. 2:EtOAc:MeOH (190:10:1) as eluant. (formula presented)
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14. 13C (125 MHz) NMR spectra, as well as appropriate parent ion identification by high-resolution mass spectrometry.
15. 4 followed by methylation (MeI/NaOH in DMSO). Structure proof followed from the independent synthesis of 20 from 21 and single crystal X-ray analysis of the bis-p-bromobenzoate corresponding to latter (i.e., 22).
16. 4 (formula presented)
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