Bioavailability of danazol-hydroxypropyl-β-cylodextrin complex by different routes of administration

International Journal of Pharmaceutics

Volumn 145, Issue 1-2, 1996, Pages 137-143

  Farag Badawy, Sherif I ^a   Ghorab, Mahmoud M ^b   Adeyeye, Christianah Moji ^a  

^a DUQUESNE UNIVERSITY   (United States)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

Bioavailability; Buccal route; Complex; Danazol; Hydroxypropyl cyclodextrin; Oral route

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ADHESIVE AGENT; DANAZOL; GELATIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG ADMINISTRATION; DRUG BLOOD LEVEL; DRUG RELEASE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0030573061     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(96)04763-1     Document Type: Article

References (14)

1. Badawy, S.I.F., Ghorab, M.M. and Adeyeye, C.M., Characterization and bioavailability of danazol-hydroxypropyl-β-cyclodextrin coprecipitates. Int. J. Pharm., 128 (1996) 45-54.
2. Bakatselou, V., Oppenheim, R.C. and Dressman, J.B., Solubilization and wetting effects of bile salts on the dissolution of steroids. Pharm. Res., 8 (1991) 1461-1469.
3. Davison, C., Banks, W. and Fritz, A., The absorption, distribution and metabolic fate of danazol in rats, monkeys and human volunteers. Arch. Int. Pharmacodyn., 221 (1976) 294-310.
4. Dmowski, W.P., Danazol: a synthetic steroid with diverse biologic effects. J. Reprod. Med., 35 (Suppl. 1) (1990) 69-74, discussion 74-75.
5. Harris, D. and Robinson, J.R., Drug delivery via the mucous membranes of the oral cavity. J. Pharm. Sci., 81 (1992) 1-10.
6. Hooper, W.D., Eadie, M.J. and Dickinson, R.G., Single oral dose pharmacokinetics and comparative bioavailability of danazol in humans. Biopharm. Drug Disp., 12 (1991) 577-582.
7. Hussain, M.A., Aungst, B.J. and Shefter, E., Buccal and oral bioavailability of nalburphine in rats. J. Pharm. Sci., 75 (1986) 218-219.
8. Hussain, M.A., Aungst, B.J., Kearney, A. and Shefter, E., Buccal and oral bioavailability of naloxone and naltrexone in rats. Int. J. Pharm., 36 (1987) 127-130.
9. Hussain, M.A., Aungst, B.J., Koval, C.A. and Shefter, E., Improved buccal delivery of opioid analgesics and antagonists with bitterless prodrugs. Pharm. Res., 5 (1988) 615-618.
10. Nair, M. and Chien, Y.W., Buccal delivery of progestational steroids: I. Characterization of barrier properties and effect of penetrant hydrophilicity. Int. J. Pharm., 89 (1993) 41-49.
11. Nerella, N.G., Block, L.H. and Noonan, P.K., The impact of lag time on the estimation of pharmacokinetic parameters. I. One-compartment open model. Pharm. Res., 10 (1993) 1031-1036.
12. Nygard, G.A., Lovett, L.J., Erdmann, G.R. and Khalil, S.K.W., Analysis of danazol in serum using high-performance liquid chromatography. J. Chromatogr., 415 (1987) 438-444.
13. Pitha, J., Harman, M. and Michel, M.E., Hydrophilic cyclodextrin derivatives enable effective oral administration of steroidal hormones. J. Pharm. Sci., 75 (1986) 165-167.
14. Szejtli, J., Cyclodextrin Technology, Academic Publisher, Dordrecht, The Netherlands, 1988.