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Volumn 75, Issue 1, 1996, Pages 99-109

Accumulation and extrusion of permeant Ca2+ chelators in attenuation of synaptic transmission at hippocampal CA1 neurons

Author keywords

BAPTA AM; calcium chelators; field excitatory postsynaptic potential; hippocampus; probenecid; synaptic transmission

Indexed keywords

CALCIUM CHELATING AGENT; EGTAZIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; PROBENECID;

EID: 0030572758     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-4522(96)00319-3     Document Type: Article
Times cited : (36)

References (65)
  • 1
    • 0025947123 scopus 로고
    • Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse
    • Adler E. M., Augustine G. J., Duffy S. N., Charlton M. P. Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse. J. Neurosci. 11:1991;1469-1477.
    • (1991) J. Neurosci. , vol.11 , pp. 1469-1477
    • Adler, E.M.1    Augustine, G.J.2    Duffy, S.N.3    Charlton, M.P.4
  • 2
    • 0025047521 scopus 로고
    • Glucose mediated efflux of indo-1 from pancreatic B-cells is reduced by probenecid
    • Arkhammar P., Nilsson T., Berggenn P. O. Glucose mediated efflux of indo-1 from pancreatic B-cells is reduced by probenecid. Fedn Eur. biochem. Socs Lett. 273:1991;182-184.
    • (1991) Fedn Eur. Biochem. Socs Lett. , vol.273 , pp. 182-184
    • Arkhammar, P.1    Nilsson, T.2    Berggenn, P.O.3
  • 3
    • 0026399923 scopus 로고
    • The calcium signal for transmitter secretion from presynaptic nerve terminals
    • Augustine G. J., Adler E. M., Charlton M. P. The calcium signal for transmitter secretion from presynaptic nerve terminals. Ann. NY Acad. Sci. 636:1991;365-381.
    • (1991) Ann. NY Acad. Sci. , vol.636 , pp. 365-381
    • Augustine, G.J.1    Adler, E.M.2    Charlton, M.P.3
  • 5
    • 85030272345 scopus 로고
    • 2+-buffering with BAPTA enhances glutamate excitotoxicity in vitro and ischemic damage in vivo
    • 2+-buffering with BAPTA enhances glutamate excitotoxicity in vitro and ischemic damage in vivo. Soc. Neurosci. Abstr. 18:1992;565.11.
    • (1992) Soc. Neurosci. Abstr. , vol.18 , pp. 56511
    • Baimbridge, K.G.1    Abdel-Hamid, K.M.2
  • 6
    • 0026674267 scopus 로고
    • 2+-dependent components of facilitation at mouse endplates
    • 2+-dependent components of facilitation at mouse endplates. J. Physiol. 455:1992;383-405.
    • (1992) J. Physiol. , vol.455 , pp. 383-405
    • Bain, I.A.1    Quastel, D.M.J.2
  • 7
    • 0028854936 scopus 로고
    • Presynaptic calcium activated potassium channels and calcium channels at a crayfish neuromuscular junction
    • Blundon J. A., Wright S. N., Brodwick M. S., Bittner G. D. Presynaptic calcium activated potassium channels and calcium channels at a crayfish neuromuscular junction. J. Neurophysiol. 73:1995;178-189.
    • (1995) J. Neurophysiol. , vol.73 , pp. 178-189
    • Blundon, J.A.1    Wright, S.N.2    Brodwick, M.S.3    Bittner, G.D.4
  • 9
    • 0026210838 scopus 로고
    • Toxicity to isolated hepatocytes caused by the intracellular calcium indicator quin-2
    • Carpenter-Deyo L., Duimstra J. R., Hedstrom O., Reed D. J. Toxicity to isolated hepatocytes caused by the intracellular calcium indicator quin-2. J. Pharmac. exp. Ther. 258:1991;739-746.
    • (1991) J. Pharmac. Exp. Ther. , vol.258 , pp. 739-746
    • Carpenter-Deyo, L.1    Duimstra, J.R.2    Hedstrom, O.3    Reed, D.J.4
  • 10
    • 0011916272 scopus 로고
    • Exogenous calcium buffer reduces synaptic transmitter release and facilitation
    • Charlton M. P., Iwanchshyn G. Exogenous calcium buffer reduces synaptic transmitter release and facilitation. Soc. Neurosci. Abstr. 12:1986;817.
    • (1986) Soc. Neurosci. Abstr. , vol.12 , pp. 817
    • Charlton, M.P.1    Iwanchshyn, G.2
  • 11
    • 0020005023 scopus 로고
    • Role of presynaptic calcium ions and channels in synaptic facilitation and depression at the squid giant synapse
    • Charlton M. P., Smith S. J., Zucker R. S. Role of presynaptic calcium ions and channels in synaptic facilitation and depression at the squid giant synapse. J. Physiol. 323:1982;173-193.
    • (1982) J. Physiol. , vol.323 , pp. 173-193
    • Charlton, M.P.1    Smith, S.J.2    Zucker, R.S.3
  • 12
    • 0023753142 scopus 로고
    • Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage
    • Choi D. W. Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci. 11:1988;465-467.
    • (1988) Trends Neurosci. , vol.11 , pp. 465-467
    • Choi, D.W.1
  • 13
    • 0028799654 scopus 로고
    • Calcium: Still centre in hypoxic-ischemic neuronal death
    • Choi D. W. Calcium: still centre in hypoxic-ischemic neuronal death. Trends Neurosci. 18:1995;58-60.
    • (1995) Trends Neurosci. , vol.18 , pp. 58-60
    • Choi, D.W.1
  • 14
    • 0027529651 scopus 로고
    • 2+-independent secretion and phospholipase D activity in permeabilized human platelets
    • 2+-independent secretion and phospholipase D activity in permeabilized human platelets. Fedn Eur. biochem. Socs Lett. 316:1993;170-174.
    • (1993) Fedn Eur. Biochem. Socs Lett. , vol.316 , pp. 170-174
    • Coorssen, J.R.1    Haslam, R.J.2
  • 15
    • 0024789690 scopus 로고
    • Zinc forms complexes with higher kinetical stability than calcium, 5-F-BAPTA as a good example
    • Csermely P., Sandor P., Radics L., Somogyi J. Zinc forms complexes with higher kinetical stability than calcium, 5-F-BAPTA as a good example. Biochem. biophys. Res. Commun. 165:1989;838-844.
    • (1989) Biochem. Biophys. Res. Commun. , vol.165 , pp. 838-844
    • Csermely, P.1    Sandor, P.2    Radics, L.3    Somogyi, J.4
  • 16
    • 0025216266 scopus 로고
    • Inhibition of Fura-2 sequestration and secretion with organic anion transport blockers
    • Di Virgilio F., Steinberg T. H., Silverstein S. C. Inhibition of Fura-2 sequestration and secretion with organic anion transport blockers. Cell Calcium. 11:1990;57-62.
    • (1990) Cell Calcium , vol.11 , pp. 57-62
    • Di Virgilio, F.1    Steinberg, T.H.2    Silverstein, S.C.3
  • 17
    • 0015879939 scopus 로고
    • Drug inhibition of PAH transport from cerebrospinal fluid in rabbits
    • Domer F. R. Drug inhibition of PAH transport from cerebrospinal fluid in rabbits. Expl Neurol. 40:1973;414-423.
    • (1973) Expl Neurol. , vol.40 , pp. 414-423
    • Domer, F.R.1
  • 18
    • 0027273297 scopus 로고
    • Effects of calcium chelators on intracellular calcium and excitotoxicity
    • Dubinsky J. M. Effects of calcium chelators on intracellular calcium and excitotoxicity. Neurosci. Lett. 150:1993;129-132.
    • (1993) Neurosci. Lett. , vol.150 , pp. 129-132
    • Dubinsky, J.M.1
  • 19
    • 0013941872 scopus 로고
    • Blood-brain and CSF barriers to penicillin and related organic acids
    • Fishman R. A. Blood-brain and CSF barriers to penicillin and related organic acids. Arch. Neurol. 15:1966;113-124.
    • (1966) Arch. Neurol. , vol.15 , pp. 113-124
    • Fishman, R.A.1
  • 21
    • 0028300775 scopus 로고
    • Reduction by intracellular calcium chelation of acetylcholine secretion without occluding the effects of adenosine at the frog motor nerve endings
    • Hunt J. M., Redman R. S., Silinsky E. M. Reduction by intracellular calcium chelation of acetylcholine secretion without occluding the effects of adenosine at the frog motor nerve endings. Br. J. Pharmac. 111:1994;753-758.
    • (1994) Br. J. Pharmac. , vol.111 , pp. 753-758
    • Hunt, J.M.1    Redman, R.S.2    Silinsky, E.M.3
  • 22
    • 0023789543 scopus 로고
    • Calcium independent increase of transmitter release at frog endplate by trinitrobenzene sulphonic acid
    • Kijima H., Tanabe N. Calcium independent increase of transmitter release at frog endplate by trinitrobenzene sulphonic acid. J. Physiol. 403:1988;135-149.
    • (1988) J. Physiol. , vol.403 , pp. 135-149
    • Kijima, H.1    Tanabe, N.2
  • 23
    • 0028299479 scopus 로고
    • Contribution of probenecid-sensitive anion transport processes at the brain capillary endothelium and choroid plexus to the efficient efflux of valproic acid from the central nervous system
    • Kimberly D. K., Adikson A. A., Arthur K. M., Powers K. M., Shen D. D. Contribution of probenecid-sensitive anion transport processes at the brain capillary endothelium and choroid plexus to the efficient efflux of valproic acid from the central nervous system. J. Pharmac. exp. Ther. 268:1994;797-805.
    • (1994) J. Pharmac. Exp. Ther. , vol.268 , pp. 797-805
    • Kimberly, D.K.1    Adikson, A.A.2    Arthur, K.M.3    Powers, K.M.4    Shen, D.D.5
  • 24
    • 0023905988 scopus 로고
    • Zinc alters excitatory amino acid neurotoxicity on cortical neurons
    • Koh J. Y., Choi D. W. Zinc alters excitatory amino acid neurotoxicity on cortical neurons. J. Neurosci. 8:1988;2164-2171.
    • (1988) J. Neurosci. , vol.8 , pp. 2164-2171
    • Koh, J.Y.1    Choi, D.W.2
  • 27
    • 0024347735 scopus 로고
    • Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurons
    • Mayer M. L., Vyklicky L., Westbrook G. L. Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurons. J. Physiol. 415:1989;329-350.
    • (1989) J. Physiol. , vol.415 , pp. 329-350
    • Mayer, M.L.1    Vyklicky, L.2    Westbrook, G.L.3
  • 29
    • 0017226759 scopus 로고
    • Transport of organic cations and anions by choroid plexus
    • Miller T. B., Ross C. R. Transport of organic cations and anions by choroid plexus. J. Pharmac. exp. Ther. 196:1976;771-777.
    • (1976) J. Pharmac. Exp. Ther. , vol.196 , pp. 771-777
    • Miller, T.B.1    Ross, C.R.2
  • 30
    • 0027254641 scopus 로고
    • The differentiation inducer, dimethyl sulfoxide, transiently increases the intracellular calcium ion concentration in various cell types
    • Morley P., Whitefield J. F. The differentiation inducer, dimethyl sulfoxide, transiently increases the intracellular calcium ion concentration in various cell types. J. Cell Physiol. 156:1993;219-225.
    • (1993) J. Cell Physiol. , vol.156 , pp. 219-225
    • Morley, P.1    Whitefield, J.F.2
  • 32
    • 0028988346 scopus 로고
    • Maintenance of Fura-2 fluorescence in glial cells and neurones of the leech central nervous system
    • Munsch T., Deitmer J. W. Maintenance of Fura-2 fluorescence in glial cells and neurones of the leech central nervous system. J. neurosci. Meth. 57:1995;195-204.
    • (1995) J. Neurosci. Meth. , vol.57 , pp. 195-204
    • Munsch, T.1    Deitmer, J.W.2
  • 33
    • 0025781309 scopus 로고
    • Postsynaptic and presynaptic effects of the calcium chelator BAPTA on synaptic transmission in rat hippocampal dentate granule neurons
    • Niesen C., Charlton M. P., Carlen P. L. Postsynaptic and presynaptic effects of the calcium chelator BAPTA on synaptic transmission in rat hippocampal dentate granule neurons. Brain Res. 555:1991;319-325.
    • (1991) Brain Res. , vol.555 , pp. 319-325
    • Niesen, C.1    Charlton, M.P.2    Carlen, P.L.3
  • 34
    • 0027530592 scopus 로고
    • Time courses of calcium and calcium-bound buffers following calcium influx in a model cell
    • Nowyscky M. C., Pinter M. J. Time courses of calcium and calcium-bound buffers following calcium influx in a model cell. Biophys. J. 64:1993;77-91.
    • (1993) Biophys. J. , vol.64 , pp. 77-91
    • Nowyscky, M.C.1    Pinter, M.J.2
  • 35
    • 0011988039 scopus 로고
    • The membrane permeable calcium chelator, BAPTA-AM, attenuates synaptic transmission in vitro in the hippocampus CA1 region
    • Ouanounou A., Zhang L., Tymianski M., Charlton M. P., Wallace M. C., Carlen P. L. The membrane permeable calcium chelator, BAPTA-AM, attenuates synaptic transmission in vitro in the hippocampus CA1 region. Soc. Neurosci. Abstr. 21:1995;1565.
    • (1995) Soc. Neurosci. Abstr. , vol.21 , pp. 1565
    • Ouanounou, A.1    Zhang, L.2    Tymianski, M.3    Charlton, M.P.4    Wallace, M.C.5    Carlen, P.L.6
  • 36
    • 0017600519 scopus 로고
    • Transport of metabolic substrate through the blood-brain-barrier
    • Pardridge W. M., Oldendrof W. H. Transport of metabolic substrate through the blood-brain-barrier. J. Neurochem. 28:1977;5-12.
    • (1977) J. Neurochem. , vol.28 , pp. 5-12
    • Pardridge, W.M.1    Oldendrof, W.H.2
  • 37
    • 0024277382 scopus 로고
    • Secretory responses of rat peritoneal mast cells to high intracellular calcium
    • Penner R., Neher E. Secretory responses of rat peritoneal mast cells to high intracellular calcium. Fedn Eur. biochem. Socs Lett. 226:1988;307-313.
    • (1988) Fedn Eur. Biochem. Socs Lett. , vol.226 , pp. 307-313
    • Penner, R.1    Neher, E.2
  • 38
    • 0023253615 scopus 로고
    • Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons
    • Peters S., Koh J., Choi D. W. Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons. Science. 236:1987;589-593.
    • (1987) Science , vol.236 , pp. 589-593
    • Peters, S.1    Koh, J.2    Choi, D.W.3
  • 40
    • 0027954648 scopus 로고
    • The role of presynaptic calcium in short-term enhancement at the hippocampal mossy fiber synapse
    • Regehr W. G., Delaney K. R., Tank D. W. The role of presynaptic calcium in short-term enhancement at the hippocampal mossy fiber synapse. J. Neurosci. 14:1994;523-537.
    • (1994) J. Neurosci. , vol.14 , pp. 523-537
    • Regehr, W.G.1    Delaney, K.R.2    Tank, D.W.3
  • 42
    • 0027291009 scopus 로고
    • Calcium and calcium gated potassium channels at the frog neuromuscular junction
    • Robitaille R., Adler E. M., Charlton M. P. Calcium and calcium gated potassium channels at the frog neuromuscular junction. J. Physiol., Paris. 87:1993;15-24.
    • (1993) J. Physiol., Paris , vol.87 , pp. 15-24
    • Robitaille, R.1    Adler, E.M.2    Charlton, M.P.3
  • 43
    • 0026392949 scopus 로고
    • Frequency facilitation is not caused by residual ionised calcium at the frog neuromuscular junction
    • Robitaille R., Charlton M. P. Frequency facilitation is not caused by residual ionised calcium at the frog neuromuscular junction. Ann. N.Y. Acad. Sci. 635:1991;492-494.
    • (1991) Ann. N.Y. Acad. Sci. , vol.635 , pp. 492-494
    • Robitaille, R.1    Charlton, M.P.2
  • 44
    • 0026596694 scopus 로고
    • Presynaptic calcium signals and transmitter release are modulated by calcium activated potassium channels
    • Robitaille R., Charlton M. P. Presynaptic calcium signals and transmitter release are modulated by calcium activated potassium channels. J. Neurosci. 12:1992;297-305.
    • (1992) J. Neurosci. , vol.12 , pp. 297-305
    • Robitaille, R.1    Charlton, M.P.2
  • 45
    • 0027365126 scopus 로고
    • Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release
    • Robitaille R., Garcia M. L., Kaczorowski G. J., Charlton M. P. Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release. Neuron. 11:1993;645-655.
    • (1993) Neuron , vol.11 , pp. 645-655
    • Robitaille, R.1    Garcia, M.L.2    Kaczorowski, G.J.3    Charlton, M.P.4
  • 46
    • 0020585505 scopus 로고
    • Synaptic activity mediates death of hypoxic neurons
    • Rothman S. M. Synaptic activity mediates death of hypoxic neurons. Science. 220:1983;536-537.
    • (1983) Science , vol.220 , pp. 536-537
    • Rothman, S.M.1
  • 47
    • 0021125414 scopus 로고
    • Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death
    • Rothman S. M. Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death. J. Neurosci. 4:1984;1884-1891.
    • (1984) J. Neurosci. , vol.4 , pp. 1884-1891
    • Rothman, S.M.1
  • 48
    • 0022620257 scopus 로고
    • Glutamate and the pathophysiology of hypoxic-ischemic brain damage
    • Rothman S. M., Olney J. W. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann. Neurol. 19:1986;105-111.
    • (1986) Ann. Neurol. , vol.19 , pp. 105-111
    • Rothman, S.M.1    Olney, J.W.2
  • 49
    • 0024313686 scopus 로고
    • Protection of dentate hilar cells from prolonged stimulation by intracellular calcium chelation
    • Scharfman H. E., Schwartzkroin P. A. Protection of dentate hilar cells from prolonged stimulation by intracellular calcium chelation. Science. 246:1989;257-260.
    • (1989) Science , vol.246 , pp. 257-260
    • Scharfman, H.E.1    Schwartzkroin, P.A.2
  • 50
    • 0026521763 scopus 로고
    • Effects of intracellular calcium chelation on voltage-dependent and calcium-dependent currents in cat neocortical neurons
    • Schwindt P. C., Spain W. J., Crill W. E. Effects of intracellular calcium chelation on voltage-dependent and calcium-dependent currents in cat neocortical neurons. Neuroscience. 47:1992;571-578.
    • (1992) Neuroscience , vol.47 , pp. 571-578
    • Schwindt, P.C.1    Spain, W.J.2    Crill, W.E.3
  • 51
    • 84886640673 scopus 로고
    • A stopped-flow investigation of calcium ion binding by ethylene glycol bis(β-aminoethyl ether)-N,N′-tetraacetic acid
    • Smith P. D., Liesegang G. W., Berger R. L., Czerlinsky G., Podolsky R. J. A stopped-flow investigation of calcium ion binding by ethylene glycol bis(β-aminoethyl ether)-N,N′-tetraacetic acid. Analyt. Biochem. 143:1984;188-195.
    • (1984) Analyt. Biochem. , vol.143 , pp. 188-195
    • Smith, P.D.1    Liesegang, G.W.2    Berger, R.L.3    Czerlinsky, G.4    Podolsky, R.J.5
  • 52
    • 0028876621 scopus 로고
    • Determination of intracellular calcium in vivo via fluorine-19 nuclear magnetic resonance spectroscopy
    • Song S. W., Hotchkiss R. S., Neil J., Morris P. E. Jr., Hsu C. Y., Ackerman J. J. H. Determination of intracellular calcium in vivo via fluorine-19 nuclear magnetic resonance spectroscopy. Am. J. Physiol. 269:1995;C318-C322.
    • (1995) Am. J. Physiol. , vol.269
    • Song, S.W.1    Hotchkiss, R.S.2    Neil, J.3    Morris P.E., Jr.4    Hsu, C.Y.5    Ackerman, J.J.H.6
  • 53
    • 0022630276 scopus 로고
    • Ceftriaxone pharmakokinetics in the central nervous system
    • Spector R. Ceftriaxone pharmakokinetics in the central nervous system. J. Pharmac. exp. Ther. 236:1986;380-383.
    • (1986) J. Pharmac. Exp. Ther. , vol.236 , pp. 380-383
    • Spector, R.1
  • 54
    • 0015998620 scopus 로고
    • The effects of salicylate and probenecid on the cerebrospinal fluid of penicillin, aminosalicylic acid and iodide
    • Spector R., Lorenzo A. V. The effects of salicylate and probenecid on the cerebrospinal fluid of penicillin, aminosalicylic acid and iodide. J. Pharmac. exp. Ther. 188:1974;55-65.
    • (1974) J. Pharmac. Exp. Ther. , vol.188 , pp. 55-65
    • Spector, R.1    Lorenzo, A.V.2
  • 56
    • 0026757698 scopus 로고
    • 2+-dependent and independent components of transmitter release at the frog neuromuscular junction
    • 2+-dependent and independent components of transmitter release at the frog neuromuscular junction. J. Physiol. 455:1992;271-289.
    • (1992) J. Physiol. , vol.455 , pp. 271-289
    • Tanabe, N.1    Kijima, H.2
  • 57
    • 0019333905 scopus 로고
    • New calcium indicators and buffers with high selectivity against Mg and protons: Design, synthesis, and prototype structures
    • Tsien R. Y. New calcium indicators and buffers with high selectivity against Mg and protons: design, synthesis, and prototype structures. Biochemistry. 19:1980;2396-2404.
    • (1980) Biochemistry , vol.19 , pp. 2396-2404
    • Tsien, R.Y.1
  • 58
    • 0019829560 scopus 로고
    • A non-disruptive technique for loading calcium buffers and indicators into cells
    • Tsien R. Y. A non-disruptive technique for loading calcium buffers and indicators into cells. Nature. 290:1981;527-528.
    • (1981) Nature , vol.290 , pp. 527-528
    • Tsien, R.Y.1
  • 62
    • 0024761050 scopus 로고
    • Long-term potentiation of hippocampal mossy fibre synapses is blocked by postsynaptic injection of calcium chelator
    • Williams S., Johnston D. Long-term potentiation of hippocampal mossy fibre synapses is blocked by postsynaptic injection of calcium chelator. Neuron. 3:1989;583-588.
    • (1989) Neuron , vol.3 , pp. 583-588
    • Williams, S.1    Johnston, D.2
  • 63
    • 0027942461 scopus 로고
    • Homosynaptic facilitation of transmitter release in crayfish is not affected by mobile calcium chelator: Implications for the residual ionized calcium hypothesis from electrophysiological and computational analyses
    • Winslow J. L., Duffy S. N., Charlton M. P. Homosynaptic facilitation of transmitter release in crayfish is not affected by mobile calcium chelator: implications for the residual ionized calcium hypothesis from electrophysiological and computational analyses. J. Neurophysiol. 72:1994;1769-1793.
    • (1994) J. Neurophysiol. , vol.72 , pp. 1769-1793
    • Winslow, J.L.1    Duffy, S.N.2    Charlton, M.P.3
  • 64
    • 0026089456 scopus 로고
    • A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmission
    • Xie X., Smart T. G. A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmission. Nature. 349:1991;521-524.
    • (1991) Nature , vol.349 , pp. 521-524
    • Xie, X.1    Smart, T.G.2


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