In vitro drug release from porous cellulose matrices

International Journal of Pharmaceutics

Volumn 141, Issue 1-2, 1996, Pages 53-62

  Gren, T ^a,c   Bjerre, C ^b   Camber, O ^b   Ragnarsson, G ^b,d  

^a Pharmacia & Upjohn AB   (Sweden)

^b PFIZER INC   (United States)

^c UPPSALA UNIVERSITY   (Sweden)

^d ASTRAZENECA R AND D   (Sweden)

Author keywords

Drug release; In vitro dissolution; Inert matrix; Multiple units; Porous cellulose matrices

Indexed keywords

CAFFEINE; CELLULOSE; INDOMETACIN; OXAZEPAM; PARACETAMOL; PROPIOMAZINE MALEATE; THEOPHYLLINE;

ARTICLE; DIFFUSION; DISSOLUTION; DRUG RELEASE; DRUG SOLUBILITY; ENCAPSULATION; EVAPORATION; PARTICLE SIZE; PHYSICAL PHENOMENA; PRIORITY JOURNAL;

EID: 0030572666     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(96)04614-5     Document Type: Article

References (13)

1. Allen, T., Particle Size Measurement, 2nd Edn., Chapman and Hall, London, 1975, p. 80.
2. Baker, R.W. and Lonsdale, H.K., Controlled release: mechanisms and rates. In Tanquary, A.C. and Lacey, R.E. (Eds), Controlled Release of Biologically Active Agents, Plenum Press, New York, 1974, p. 46.
3. Björk, S. and Nyqvist, H., Control of in-vitro-release of drugs from agglomerated cellulose. Proc. Congr. Swedish Academy of Pharmaceutical Sciences, Stockholm, Sweden. 1991.
4. Davidson, R., Nyqvist, H. and Ragnarsson, G., Porous cellulose matrices - a novel excipient for the formulation of solid dosage forms. Int. J. Pharm., 100 (1993) 49-54.
5. Davidson, R., Ek, R. and Ragnarsson, G., Determination of the expansion characteristics of porous cellulose matrices by image analysis. Int. J. Pharm., 112 (1994) 153-163.
6. Ek, R., Eriksson, K., Nyqvist, H. and Ragnarsson, G., Process for the manufacture of porous cellulose matrices. Int. Patent Applic. WO 91 18590 (1991).
7. Ek, R., Henriksson, U., Nyström, C. and Ödberg, L., Pore characterization in porous cellulose beads using the spin echo NMR technique. Powder Technol., 81 (1994) 279-286.
8. Ek, R., Gren, T., Henriksson, U., Nyqvist, H., Nyström, C. and Ödberg, L., Prediction of drug release by characterization of the tortuosity in porous cellulose beads using spin echo NMR technique. Int. J. Pharm., 124 (1995) 9-18.
9. Higuchi, T., Mechanism of sustained action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J. Pharm. Sci., 52 (1963) 1145-1149.
10. Hixon, A.W. and Crowell, J.H., Dependence of reaction velocity upon surface agitation. Ind. Eng. Chem., 23 (1931) 923-931.
11. Noyes, A.A. and Whitney W.R., Ueber die Auflösungsgeschwindigkeit von festen Stoffen in Ihren eigenen Lösungen. Z. Phys. Chem., 23 (1897) 689-692.
12. O'Connor, R.E. and Schwarz, J.B., Drug release mechanism from a microcrystalline cellulose pellet system. Pharm. Res., 10 (1993) 356-361.
13. Ritger, P.L. and Peppas, N.A., A simple equation for the description of solute release I: Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders and discs. J. Controlled Release, 5 (1987) 23-36.