Formulation strategies designed to maintain the biphasic release characteristics of liquid-filled capsules

International Journal of Pharmaceutics

Volumn 141, Issue 1-2, 1996, Pages 9-16

  Burns, S J ^a   Higginbottom, S ^b   Whelan, I ^c   Bowtle, W J ^d   Rosenberg, E ^b   Corness, D ^b   Hay, G ^b   Attwood, D ^e   Barnwell, S G ^b  

^a ASTRAZENECA   (United Kingdom)

^b Techbase 1 ^*  (United Kingdom)

^c Scotia Pharmaceutical   (United Kingdom)

^d MW Encap Ltd   (United Kingdom)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Biphasic release; Dissolution testing; Enteric coating; HALO(TM) drug delivery system; Liquid filled capsules; Phase barrier; Propranolol

Indexed keywords

GELUCIRE; PROPRANOLOL;

ARTICLE; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; ENTERIC COATED TABLET; PRIORITY JOURNAL; STORAGE;

EID: 0030572658     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(96)04598-X     Document Type: Article

References (14)

1. Aungst, B.J. and Hussain, M.A., Sustained propranolol delivery and increased oral bioavailability in dogs given a propranolol laurate salt. Pharm. Res., 9 (1992) 1507-1509.
2. Barnwell, S.G., Biphasic release formulations for lipophilic drugs. Int. Patent Applic. W092/06680 (1992).
3. Barnwell, S.G., Biphasic release formulations for lipophilic acids. US Patent 5,391,377 (1995a).
4. Barnwell, S.G., Biphasic release formulations for lipophilic drugs. Eur. Patent 0553178 (1995b).
5. Barnwell, S.G., Gauci, L., Harris, R.J., Attwood, D., Littlewood, G., Guard, P., Pickup, M.E. and Barrington, P., Greatly enhanced oral bioavailability of propranolol using the HALO™ liver-bypass delivery system. Capsule News, 8 (1993) 2-3.
6. Barnwell, S.G., Gauci, L., Harris, R.J., Attwood, D., Littlewood, G., Guard, P., Pickup, M.E. and Barrington, P., Greatly enhanced oral bioavailability of propranolol using the HALO™ liver-bypass delivery system. J. Controlled Release, 28 (1994) 306-309.
7. Barnwell, S.G., Higginbottom, S., Whelan, I. and Burns, S.J., Biphasic capsule formulations, Int. Patent Applic. W095/ 16435 (1995).
8. Barnwell, S.G., Burns, S.J., Higginbottom, S., Whelan, I., Corness, D., Hay, G., Rosenberg, E. and Attwood, D. Demonstration of the importance of biphasic oleic acid delivery for enhancing the bioavailability of propranolol in healthy volunteers. Int. J. Pharm., 128 (1996) 145-154.
9. British Pharmacopoeia, HMSO, London, 1993, Appendix A160-A161.
10. Burns, S.J., Higginbottom, S., Corness, D., Hay, G., Whelan, I., Attwood, D. and Barnwell, S.G., A study of entericcoated liquid-filled hard gelatin capsules with biphasic release characteristics. Int. J. Pharm., 110 (1994) 291-296.
11. Burns, S.J., Corness, D., Higginbottom, S., Hay, G., Whelan, I., Attwood, D. and Barnwell, S.G., Development and validation of an in vitro dissolution method for a floating dosage form with biphasic release characteristics. Int. J. Pharm., 121 (1995) 37-44.
12. Burns, S.J., Corness, D., Higginbottom, S., Whelan, I., Attwood, D. and Barnwell, S.G., An in vitro assessment of liquid-filled Capill® potato starch capsules with biphasic release characteristics. Int. J. Pharm., 130 (1996) 223-230.
13. Tucker, G., Drug delivery: lymphing along? Lancet, 341 (1993) 1314-1315.
14. US Pharmacopeia XXII, US Pharmacopeial Convention, Rockville, MD, 1990, pp. 1579-1580.