Kinetic, dynamic, and pathway studies of glycerol metabolism by Klebsiella pneumoniae in anaerobic continuous culture: II. Analysis of metabolic rates and pathways under oscillation and steady-state conditions

Biotechnology and Bioengineering

Volumn 52, Issue 5, 1996, Pages 561-571

  Zeng, An Ping ^a   Menzel, Kirsten ^a   Deckwer, Wolf Dieter ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

glycerol metabolism; Klebsiella pneumoniae; metabolic fluxes; oscillation; pathway analysis

Indexed keywords

CONTINUOUS CELL CULTURE; ENZYMES; FERMENTATION; FLUXES; GLYCEROL; GROWTH KINETICS; HYSTERESIS; METABOLISM; OSCILLATIONS; STOICHIOMETRY;

KLEBSIELLA PNEUMONIAE; METABOLIC FLUXES; PATHWAY ANALYSIS; PYRUVATE;

BIOTECHNOLOGY;

ANAEROBIC METABOLISM; ARTICLE; BACTERIAL METABOLISM; BACTERIUM CULTURE; CALCULATION; KLEBSIELLA PNEUMONIAE; METABOLIC RATE; NONHUMAN; OSCILLATION;

BACTERIA (MICROORGANISMS); KLEBSIELLA PNEUMONIAE;

EID: 0030571579     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19961205)52:5<561::AID-BIT3>3.3.CO;2-F     Document Type: Article

References (22)

1. Clarke, K. G., Hansford, G. S., Jones, D. T. 1988. Nature and significance of oscillatory behavior during solvent production by Clostridium acetobutylicum in continuous culture. Biotechnol. Bioeng. 32: 538-544.
2. 12-dependent glycerol and diol dehydratases. J. Bacteriol. 149: 413-419.
3. Gray, P., Scott, S. K. 1994. Chemical oscillations and instabilities: nonlinear chemical kinetics. Clarendon Press, Oxford.
4. Harrison, D. E. F., MacLennan, D. G., Pirt, S. J. 1969. p. 117. In: D. Perlman (ed.), Fermentation advances. Academic Press, New York.
5. Harrison, D. E. F., Topiwala, H. H. 1974. Transient and oscillatory states of continuous culture, pp. 168-219. In: T. H. Ghose, A. Fiechter, and N. Blakesbrown (eds.), Advanced biochemical engineering, vol. 3., Springer, Berlin.
6. Herbert, D., Phipps, P. J., Strange, R. E. 1971. Chemical analysis of microbial cells, pp. 209-344. In: J. M. Norris and D. W. Ribbons (eds.), Methods in microbiology, vol. 5b. Academic Press, London.
7. Jöbses, I. M. L., Egberts, G. T. C., Luyben, K. C. A. M., Roels, J. A. 1986. Fermentation kinetics of Zymomonas mobilis at high ethanol concentrations: oscillations in continuous cultures. Biotechnol. Bioeng. 28: 868-877.
8. Lin, E. C. C. 1976. Glycerol dissimilation and its regulation in bacteria. Annu. Rev. Microbiol. 30: 535-578.
9. Menzel, K., Zeng, A.-P., Biebl, H., Deckwer. W.-D. 1996a. Kinetic, dynamic, and pathway studies of glycerol metabolism by Klebsiella pneumoniae in anaerobic continuous culture: I. The phenomena and characterization of oscillation and hysteresis. Biotechnol. Bioeng. (this issue).
10. Menzel, K., Zeng, A.-P., Deckwer, W.-D. 1996b. High concentration and productivity of 1,3-propanediol from continuous fermentation of glycerol by Klebsiella pneumoniae. Enzyme Microbiol. Technol. 52: 549-560.
11. von Meyenburg, H. K. 1973. Stable synchrony oscillations in continuous cultures of Saccharomyces cerevisiae under glucose limitation, pp 411-417. In: B. Chance, E.K. Pye, T.K. Ghosh and B. Hess (eds), Biological and biochemical oscillators. Academic, New York.
12. Neijssel, O. M., Hueting, S., Crabbendam, K. J., Tempest, D. W. 1975. Dual pathways of glycerol assimilation in Klebsiella aerogenes NCIB 418. Their regulation and possible function significance. Arch. Microbiol. 104: 83-87.
13. Ogunnaike, B. A., Ray, W. H. 1994. Process dynamics, modeling and control. Oxford University Press, Oxford.
14. Pecher, A., Zinoni, F., Jatisatienr, C., Wirth, R., Hennecke, H., Böck, A. 1983. On the redox control of synthesis of anaerobically induced enzymes in enterobacteriaceae. Arch. Microbiol. 136: 131-136.
15. Porro, D., Martegani, E., Ranzi, B. M., Alberghina, L. 1988. Oscillations in continuous cultures of budding yeast: a segregated parameter analysis. Biotechnol. Bioeng. 32: 411-417.
16. 2 ratio in Klebsiella pneumoniae during anaerobic fermentation of glycerol. Appl. Microbial. Biotechnol. 42: 222-226.
17. Streekstra, H., Teixera de Mattos, M. J., Neijssel, O. M., Tempest, D. W. 1987. Overflow metabolism during anaerobic growth of Klebsiella aerogenes NCTC 418 on glycerol and dihydroxyacetone in chemostat culture. Arch. Microbiol. 147: 268-275.
18. Tanisho, S., Kamiya, N., Wakao, N. 1989. Hydrogen evolution of Enterobacter aerogenes depending on culture pH: mechanism of hydrogen evolution from NADH by means of membrane-bound hydrogenase. Biochim. Biophys. Acta 973: 1-6.
19. Zeng, A.-P., Biebl, H., Schlieker, H., Deckwer, W.-D. 1993. Pathway analysis of glycerol fermentation by Klebsiella pneumonia: regulation of reducing equivalent balance and product formation. Enzyme Microbiol. Technol. 15: 770-779.
20. Zeng, A.-P., Ross, A., Biebl, H., Tag, C., Günzel, B., Deckwer, W.-D. 1994. Multiple product inhibition and growth modeling of Clostridium butyricum and Klebsiella pneumoniae in glycerol fermentation. Biotechnol. Bioeng. 44: 902-911.
21. Zeng, A.-P., Deckwer, W.-D. 1995. A kinetic model for substrate and energy consumption of microbial growth under substrate-sufficient conditions. Biotechnol. Prog. 11: 71-79.
22. Zeng, A.-P. 1995. A new balance equation of reducing equivalents for data consistency check and calculations of bioprocesses. J. Biotechnol. 43: 111-124.