Poly(organo phosphazene) nanoparticles surface modified with poly(ethylene oxide)

Biotechnology and Bioengineering

Volumn 52, Issue 1, 1996, Pages 89-95

  Vandorpe, J ^a   Schacht, E ^a   Stolnik, S ^b   Garnett, M C ^b   Davies, M C ^b   Illum, L ^b   Davis, S S ^b  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

biodegradable materials; nanoparticles; poly(ethylene oxide); poly(organo phosphazenes); surface modification

Indexed keywords

BIODEGRADATION; CHARACTERIZATION; DERIVATIVES; EVAPORATION; FLOCCULATION; NANOSTRUCTURED MATERIALS; PH; POLYETHYLENE OXIDES; PRECIPITATION (CHEMICAL); SURFACE TREATMENT;

BIODEGRADABLE MATERIALS; CARBOXYL GROUPS; ELECTROSTATIC REPULSIONS; NANOPARTICLES; POLY ORGANO PHOSPHAZENE;

ORGANIC POLYMERS;

BIOMATERIAL; COPOLYMER; GLYCINE ETHYL ESTER; MACROGOL; NANOPARTICLE; PHENYLALANINE DERIVATIVE; POLYMER; SOLVENT;

ADSORPTION; COLLOID; CONFERENCE PAPER; ELECTRICITY; EVAPORATION; FLOCCULATION; HYDROPHILICITY; PARTICLE SIZE; PH; PRECIPITATION; SURFACE PROPERTY;

EID: 0030571221     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19961005)52:1<89::AID-BIT8>3.0.CO;2-V     Document Type: Conference Paper

References (19)

1. Aftabroushard, S., Doelker, E 1994. Factors influencing the entrapment of a water soluble model drug into injectable microparticles prepared using solvent evaporation and phase separation techniques. Eur. J. Pharm. Biopharm. 40: 237-242.
2. Allcock, H. R., Fuller, T. J., Matsumura, K. 1987. Hydrolysis pathway for aminophosphazenes. Inorg. Chem. 12: 515.
3. Allcock, H. R., Fuller, T. J., Mack, D. P., Marsumura, K., Smeltz, K. M. 1977. Synthesis of poly[(amino acid alkylester)phosphazenes]. Macromolecules 10: 821.
4. Allcock, H. R., Pucher, S. R., Scopelianos, G. 1994. Poly[(amino acid ester)phosphazenes] as substrates for the controlled release of small molecules. Biomaterials 15: 563-570.
5. Crommen, J., Schacht, E., Mense, E. H. G. 1992. Novel biodegradable polymers: Part 1. Synthesis of hydrolysis sensitive poly[(organo)phosphazene]. Biomaterials 13: 511-520.
6. Crommen, J., Vandorpe, J., Schacht, E. 1993. Degradable polyphosphazenes for biomedical applications. J. Control. Rel. 24: 167-180.
7. Dunn, S. E., Garnett, M. C., Davis, S. S., Davies, M. C., Ilium, L. In vitro cell interaction and in vivo biodistribution of poly(lactide-coglycolide) nanospheres surface modified by Poloxamer and Poloxamine copolymers (in press).
8. Goedemoed, J. H., Mense, E. H. G., de Groot, K., Claessen, A. M. E., Scheper, R. J. 1981. Development of injectable antitumor microspheres based on polyphosphazenes. J. Control. Rel. 17: 245-258.
9. Illum, L., Davis, S. S., Muller, R. H., Mak, E., West, P. 1987. The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilised with block-copolymer-poloxamine 908. Life Sci. 40: 367-374.
10. Illum, L., Davis, S. S. 1984. The organ uptake of intravenously administered colloidal particles can be altered using nonionic surfactant (poloxamer 338). FEBS Lett. 167: 79-82.
11. Moghimi, M., Ilium, L., Davis, S. S. 1994. Organ specific targeting of synthetic and natural drug carriers, pp. 263-282. In: B. R. Zetter (ed.), Homing mechanisms and cellular targeting. Advances in molecular and cell biology, vol. 9. Marcel Dekker, New York.
12. Moghimi, S. M., Hedeman, H., Muir, I. S., Illum, L., Davis, S. S. 1993. An investigation of the filtration capacity and the fate of large filtered sterically-stabilized microspheres in rat spleen. Biochim. Biophys. Acta 1157: 233-240.
13. Muir, I. S., Moghimi, S. M., Illum, L., Davis, S. S., Davies, M. C. 1991. The effect of block copolymeres on the uptake of model microspheres by Kupffer cells - in vitro and in vivo studies. Biochem. Soc. Trans. 19: 329S.
14. Muller, R. H., Wallis, K. H., Troster, S. D., Kreuter, J. 1992. In vitro characterization of poly(methyl-methacrylate) nanospheres and correlation to their in vivo fate. J. Control. Rel. 20: 237-246.
15. Ottewill, R. H., Shaw, J. N. 1967. Studies on the preparation and characterisation of monodisperse polystyrene lattices. Part 2. Electrophoretic characterisation of surface groupings. Kolloid-Zeitschift und Zeitschrift fur Polymers 218: 34-40.
16. Porter, C. J., Moghimi, S. M., Illum, L., Davis, S. S. 1992. The polyoxyethylene/polyoxypropylene block co-polymer Poloxamer-407 selectively redirects intravenously injected microspheres to sinusoidal endothelial cells of rabbit bone marrow. FEBS Lett. 305: 62-66.
17. Senior, J., Delgado, C., Fisher, D., Tilcock, C., Gregoriadis, G. 1991. Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles. Biochim. Biophys. Acta 1062: 77-82.
18. Stolnik, S., Davis, M. C., Illum, L., Davis, S. S., Bousta, M., Vert, M. 1994a. The preparation of sub-200 nm biodegradable colloids from poly(beta-malic acid co-benzyl malate) copolymers and their surface modification with Poloxamer and Poloxamine surfactants. J. Control. Rel. 30: 57-67.
19. Stolnik, S., Dunn, S. E., Garnett, M. C., Davies, M. C., Coombes, A. G. A., Taylor, D. C., Irving, M. P., Purkiss, S. C., Tadros, T. F., Davis, S. S., Ilium, L. 1994b. Surface modification of poly(lactide-co-glycolide) nanospheres by novel biodegradable poly(lactide)-poly(ethylene glycol) copolymers. Pharm. Res. 11: 1800-1808.