Evaluation of the ability of paracetamol to produce chromosome aberrations in man

Mutation Research - Genetic Toxicology

Volumn 368, Issue 3-4, 1996, Pages 293-300

  Hantson, Ph ^a   De Saint Georges, L ^b   Mahieu, P ^a   Leonard E D ^c   Crutzen Fayt, M C ^c   Leonard A ^c  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b CEN Radiobiology ^*  (Belgium)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Genotoxicity; Paracetamol

Indexed keywords

PARACETAMOL; PROPACETAMOL;

ADULT; ARTICLE; CELL DIVISION; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOLOGY; DRUG SAFETY; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; LYMPHOCYTE; MALE; MICROTUBULE ASSEMBLY; MITOSIS INDEX; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SUICIDE;

EID: 0030570539     PISSN: 01651218     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1218(96)90071-3     Document Type: Article

References (19)

1. Kocisova J., Rossner P., Binkova B., Bavorova H., Sram R.J. Mutagenicity studies of paracetamol in human volunteers. I. Cytogenetic analysis of peripheral lymphocytes and lipid peroxidation in plasma. Mutation Res. 209:1988;161-165.
2. Topinka J., Sram R.J., Sirinjan G., Kocisova J., Binkova B., Fojtikova I. Mutagenicity studies on paracetamol in human volunteers. II. Unscheduled DNA synthesis and micronucleus test. Mutation Res. 227:1989;147-152.
3. Kocisova J., Sram R.J. Mutagenicity studies on paracetamol in human volunteers. III. Cytokinesis block micronucleus method. Mutation Res. 244:1990;27-30.
4. Hongslo J.K., Bršgger A., Bjorge C., Holme J.A. Increased frequency of sister-chromatid exchange and chromatid breaks in lymphocytes after treatment of human volunteers with therapeutic doses of paracetamol. Mutation Res. 261:1991;1-8.
5. Kirkland D.J., Dresp J.H., Marshall R.R., Baumeister M., Gerloff C., Gocke E. Normal chromosomal aberration frequencies in peripheral lymphocytes of human volunteers exposed to a maximum daily dose of paracetamol in a double blind trial. Mutation Res. 279:1992;181-194.
6. Hilali A., Léonard E.D., Decat G., Léonard A. An appraisal of the value of the contaminated Poisson method to estimate the dose inhomogeneity in simulated partial body exposure. Radiation Res. 128:1991;108-111.
7. Edinboro L.E., Jackson G.F., Jortani S.A., Poklis A. Determination of serum acetaminophen in emergency toxicology: evaluation of newer methods: Abbott TDx and second derivative ultraviolet spectrophotometry. Clin. Toxicol. 29:1991;241-255.
8. Alberts B., Bray D., Lewis J., Raff M., Roberts K., Watson J.D. Molecular Biology of the Cells. 3rd Edn. 1994;1294 Garland Publishing Inc. New York.
9. Shelanski M.L., Gaskin F., Kantor C.R. Microtubule assembly in the absence of added nucleotides. Proc. Natl. Acad. Sci. USA. 70:1973;765-768.
10. Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizaing the principles of protein dye binding. Anal. Biochem. 72:1976;248-254.
11. Malon J., Moncrieff J., Bosch E. Chronopharmacokinetics of paracetamol in normal subjects. Br. J. Clin. Pharmacol. 19:1985;843-845.
12. Hollstein M., McCann J., Angelosanto F.A., Nichols W.W. Short-term tests for carcinogens and mutagens. Mutation Res. 65:1979;133-226.
13. Kirkland D.J. Basic mutagenicity tests, UKEMS Recommanded Procedures. 1990;Cambridge University Press.
14. King M.T., Beikirch H., Eickhardt E., Gocke E., Wild D. Mutagenicity studies with X-ray-contrast media, analgesics, antipyretics, antirheumatics and some other pharmacological drugs in bacteria, Drosophila and mammalian test systems. Mutation Res. 66:1979;33-43.
15. Corcoran G.B., Mitchell J.R., Vaishnau Y.N., Horning E.C. Evidence of acetaminophen and N-hydroxy-acetaminophen from a common aryling intermediate, N-acetyl-p-benzoquinoneimine . Mol. Pharmacol. 18:1980;536-542.
16. Sawada M., Matsuoka A., Sofuni T., Jr. Ishidate M. Mutagenicity tests on phenacetin-related compounds in cultured mammalian cells. Mutation Res. 147:1985;273. (Abstr.).
17. Giri A.K. The genetic toxicology of paracetamol and aspirin: a review. Mutation Res. 296:1993;199-210.
18. IARC. IARC Monograph. Vol. 50:1990;307-332.
19. Rannug U., Holme J.A., Hongslo J.K., Sram R. An evaluation of the genetic toxicity of paracetamol. Mutation Res. 327:1995;179-200.