Serum enhances the ex vivo generation of HIV-specific cytotoxic T cells

Biotechnology and Bioengineering

Volumn 50, Issue 5, 1996, Pages 521-528

  Trimble, Linda ^a   Perales, Miguel Angel ^a   Knazek, Richard ^b   Lieberman, Judy ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

cytotoxic T lymphocytes (CTL); HIV; serum

Indexed keywords

ANIMAL CELL CULTURE; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; BLOOD; GROWTH KINETICS; IMMUNOLOGY; PATIENT TREATMENT; VIRUSES;

CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOTHERAPY; SERUM; VIRAL INFECTIONS;

CELLS;

ANTIBODY RESPONSE; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL SPECIFICITY; CELL STIMULATION; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOTHERAPY; LYMPHOKINE ACTIVATED KILLER CELL;

EID: 0030570249     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19960605)50:5<521::AID-BIT6>3.0.CO;2-H     Document Type: Article

References (24)

1. Blumberg, R. S., Paradis, T., Byington, R., Henle, W., Hirsch, M. S., Schooley, R. T. 1987. Effects of human immunodeficiency virus on the cellular immune response to Epstein-Barr virus in homosexual men: characterization of the cytotoxic response and lymphokine production. J. Infect. Dis. 155: 877-890.
2. Chakrabarti, S., Robert-Guroff, M., Wong-Staal, F., Gallo, R. C., Moss, B. 1986. Expression of the HTLV-III envelope gene by a recombinant vaccinia virus. Nature 320: 535-537.
3. Earl, P. L., Doms, R. W., Moss, B. 1990. Oligomeric structure of the human immunodeficiency virus type 1 envelope glycoprotein. Proc. Natl. Acad. Sci. USA 87: 648-652.
4. + T cell line. J. Immunother. 11: 1-11.
5. Finkelstein, D. M., Miller, R. G. 1991. Effect of culture media on lymphokine-activated killer effector phenotype and lytic capacity. Cancer Immunol. Immunother. 33: 103-108.
6. Flexner, C., Broyles, S. S., Earl, P., Chakrabarti, S., Moss, B. 1988. Characterization of human immunodeficiency virus gag/pol gene products expressed by recombinant vaccinia viruses. Virology 166: 339-349.
7. Fujioka, T., Nomura, K., Hasegawa, M., Ishikura, K., Kubo, T, 1994. Combination of lymphokine-activated killer cells and interleukin-2 in treating metastatic renal cell carcinoma. Br. J. Urol. 73: 23-31.
8. - T cell levels: Results of 6 years of follow-up. J. AIDS 6: 904-912.
9. + T lymphocytes in patients with acquired immunodeficiency syndrome (AIDS)-related complex or AIDS. Blood 81: 2093-2101.
10. Hoffenbach, A., Langlade-Demoyen, P., Dadaglio, G., Vilmer, A., Michel, F., Mayaud, C., Autran, B., Plata, F. 1989. Unusually high frequency of HIV-specific cytotoxic T lymphocytes in humans. J. Immunol. 142: 452-462.
11. Kaldjian, E. P., Chen, G.-H., Cease, K. B. 1992. Enhancement of lymphocyte proliferation assays by use of serum-free medium. J. Immunol. Meth. 147: 189-195.
12. Lamers, C. H. J., van de Griend, R. J., Braakman, E., Ronteltap, C. P. M., Benard, J., Stoter, G., Gratama, J. W., Bolhuis, R. L. H. 1992. Optimization of culture conditions for activation and large-scale expansion of human T lymphocytes for bispecific antibody-directed cellular immunotherapy. Int. J. Cancer 51: 973-979.
13. Lieberman, J., Fabry, J. A., Kuo, M.-C, Earl, P., Moss, B., Skolnik, P. R. 1992. Cytotoxic T lymphocytes from HIV-1 seropositive individuals recognize immunodominant epitopes in gp160 and reverse transcriptase. J. Immunol. 148: 2738-2747.
14. Lieberman, J., Fabry, J. A., Shankar, P., Beckett, L., Skolnik, P. R. 1995. Ex vivo expansion of HIV type 1-specific cytolytic T cells from HIV type 1-seropositive subjects. AIDS Res. Hum. Retroviruses 11: 257-271.
15. Lotze, M. T., Line, B. R., Mathisen, D. J., Rosenberg, S. A. 1980. The in vivo distribution of autologous human and marine lymphoid cells grown in T cell growth factor (TCGF): implications for the adoptive immunotherapy of tumors. J. Immunol. 125: 1487-1293.
16. Mackett, M., Smith, G. L., Moss, B. 1985. The construction and characterization of vaccinia virus recombinants expressing foreign genes, pp. 191-211. In: D. Glover (ed.), DNA cloning: a practical approach, vol. II. IRL Press, Oxford.
17. Maeda, K., Lafreniere, R., McKinnon, J. G., Jerry, L. M. 1991. Generation of human autologous melanoma-specific cytotoxic T cells from tumor-involved lymph nodes. Molec. Biother. 3: 95-102.
18. Perales, M.-A., Schwartz, D. H., Fabry, J. A., Lieberman. J. 1995. A vaccinia-gp160 based vaccine but not a gp160 protein vaccine elicits anti-gp160 cytotoxic T lymphocytes in some HIV-1 seronegative vaccinees. J. AIDS 10: 27-35.
19. Plata, F., Autran, B., Martins, L. P., Wain-Hobson, S., Raphael, M., Mayaud, C., Denis, M., Guillon, J.-M., Debre, P. 1987. AIDS virus-specific cytotoxic T lymphocytes in lung disorders. Nature (London) 328: 348-351.
20. Rosenberg, S. A., Lotze, M. T., Muul, L. M., et al. 1985. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinani interleukin-2 to patients with metastatic cancer. N. Engl. J. Med. 313: 1485-1491.
21. - cell population in the blood and lung of HIV-positive patients. J. AIDS 6: 1194-1204.
22. + cells and their relation to enhanced cytotoxic T-cell activity during human immunodeficiency virus infection. J. Clin. Immunol. 11: 345-356.
23. Walker, B. D., Chakrabarti, S., Moss, B., Paradis, T. J., Flynn, T., Durn, A. G., Blumberg, R. S., Kaplan, J. C., Hirsch, M. S., Schooley, R. T. 1987. HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature (London) 28: 345-348.
24. Yssel, H., De Vries, J. E., Koken, M., Van Blitterswijk, W., Spits, H. 1984. Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones. J. Immunol. Meth. 72: 219-227.