Synthesis of geometrically defined exocyclic olefins

Tetrahedron Letters

Volumn 37, Issue 45, 1996, Pages 8109-8112

  Bennani, Youssef L ^a,b   Hwang, C K ^a,c   Canan Koch, Stacie S ^a   Marron, Kristin S ^a   Dardashti, Laura J ^a   Badea, Beth Ann ^a   Nadzan, Alex M ^a  

^a LIGAND PHARMACEUTICALS INC   (United States)

^b ABBOTT LABORATORIES   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ESTER DERIVATIVE; PHENANTHRENE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030569270     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01885-0     Document Type: Article

References (30)

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22. 3P-HBr) and reaction of the ylide with various aldehydes gave almost exclusively thetrans exocyclic olefinic adducts. We have found that the reaction of ketone 1 with lithio-t-butyl trimethylsilyl acetate gave 40% of 2/3 esters in 8:1 (Z:E) ratio; (See a) Larson, G. L.; Betancourt de Perez, R. M. J. Org. Chem. 1985, 50, 5257;
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