A novel modification of the Ritter reaction using trimethylsilyl cyanide

Tetrahedron Letters

Volumn 37, Issue 45, 1996, Pages 8129-8132

  Chen, H G ^a   Goel, O P ^a   Kesten, S ^a   Knobelsdorf, J ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FORMAMIDE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; TECHNIQUE;

EID: 0030569265     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01890-4     Document Type: Article

References (7)

1. 1. a) Ritter, J. J.; Minieri P. P. J. Am. Chem, Soc. 1948, 70, 4045. Krimen, L. I.; Cota, D. J. Org. React. 1969, 17, 213.
2. 1. a) Ritter, J. J.; Minieri P. P. J. Am. Chem, Soc. 1948, 70, 4045. Krimen, L. I.; Cota, D. J. Org. React. 1969, 17, 213.
3. b) Leong, W. W. Comp. Org. Syn., 1991, 4, 292.
4. 2. Chen, H. G.; Chung, F.-Z.; Goel, O. P.; Kesten, S.; Knobelsdorf, J.; Lee, H. T. Poster # 223 at 211th ACS National Meeting, New Orleans, LA, March 24-28, 1996.
5. 3. Ritter, J. J.; Kalish J.; Org. Synth. Col. Vol. V, 1973, 471.
6. 4 also produced the alkene as the sole product.
7. 4 was used. In entry 2, 97% yield was obtained with HOAc as solvent, and 76% yield in entry 6.