Protein kinase C-independent activation of mitogen-activated protein kinase by epidermal growth factor in skin fibroblasts

European Journal of Pharmacology

Volumn 307, Issue 3, 1996, Pages 339-345

  Le Panse, Rozen ^a   Mitev, Vanio ^b,c   Houdebine, Louis Marie ^b   Coulomb, Bernard ^a  

^a SAINT LOUIS HOSPITAL   (France)

^b CEMAGREF   (France)

^c MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

Dermal fibroblast, human; EGF (epidermal growth factor); Isoforms (p42(mapk) and p44(mapk)); MAPK (mitogen activated protein kinase); Protein kinase C

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MYELIN BASIC PROTEIN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SKIN FIBROBLAST;

EID: 0030568713     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00278-6     Document Type: Article

References (28)

1. 2+-and TPA-sensitive PKC in HT-29 human intestinal epithelial cells, FEBS Lett. 344, 161.
2. Carpenter, G. and S. Cohen, 1979, Epidermal growth factor, Ann. Rev. Biochem. 48, 193.
3. Chao, T.-S.O., D.A. Foster, U.R. Rapp and M.R. Rosner, 1994, Differential raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium, J. Biol. Chem. 269, 7337.
4. Cochet, C., G.N. Gill, J. Meisenhelder, J.A. Cooper and T. Hunter, 1984, C-kinase phosphorylates the epidermal growth factor-receptor and reduces its epidermal growth factor stimulated tyrosine protein kinase activity. J. Biol. Chem. 259, 2553.
5. Coulomb, B. and L. Dubertret, 1992, Production and use of skin cell cultures for the in vitro testing of chemicals and pharmaceuticals, in: Animal cell biotechnology, eds. R.E. Spier and J.B. Griffiths (Academic Press, London) p. 123.
6. Dubois, M.-F., V.T. Nguyen, M.E. Dahmus, G. Pages, J. Pouysségur and O. Bensaude, 1994, Enhanced phosphorylation of the C-terminus domain of RNA polymerase II upon serum stimulation of quiescent cells: possible involvement of MAP kinases, EMBO J. 13, 4787.
7. Dvir, A., Y. Milner, O. Chomsky, C. Gilon, A. Gazit and A. Levitzki, 1991, The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers, J. Cell Biol. 113, 857.
8. Force, T., J.V. Bonventre, G. Heidecker, U.R. Rapp, J. Avruch and J.M. Kyriakis, 1994, Enzymatic characteristics of the c-raf-1 protein kinase, Proc. Natl. Acad. Sci. USA 91, 1270.
9. 2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts, J. Biol. Chem. 263, 5396.
10. Kahan, C., K. Seuwen, S. Meloche and J. Pouysségur, 1992, Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts, J. Biol. Chem. 267, 13369.
11. Kazanietz, M.G., L.B. Areces, A. Bahador, H. Mischak, J. Goodnight, J.F. Mushinski and P.M. Blumberg, 1993, Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isoenzymes. Mol. Pharmacol. 44, 298.
12. L'Allemain, G. and J. Pouysségur, 1986, EGF and insulin action in fibroblasts, FEBS Lett. 197, 344.
13. Le Panse, R., B. Coulomb, V. Mitev, B. Bouchard, C. Lebreton and L. Dubertret, 1994a, Differential modulation of human fibroblast and keratinocyte growth by the protein kinase C inhibitor GF 109203X, Mol. Pharmacol. 46, 445.
14. Le Panse, R., V. Mitev, C. Lebreton and B. Coulomb, 1994b, Modulation of epidermal growth factor and keratinocyte growth factor effects on human keratinocyte growth by protein kinase C inhibitor, GF 109203X: Comparison to fibroblast growth modulation, Biochem. Biophys. Res. Commun. 204, 1081.
15. Marquardt, B., D. Frith and S. Stabel, 1994, Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro, Oncogene 9, 3213.
16. Martiny-Baron, G., M.G. Kazanietz, H. Mischak, P.M. Blumberg, G. Kochs, H. Hug, D. Marme, and C. Schächtele, 1993, Selective inhibition of protein kinase C isoenzymes by the indolcarbazole GÖ 6976, J. Biol. Chem. 268, 9194.
17. Meisenhelder, J., P.G. Suh, S.G. Rhee and T. Hunter, 1989, Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro. Cell 57, 1109.
18. Mitev, V., R. Le Panse, B. Coulomb and L-M. Houdebine, 1995, Epidermal growth factor stimulates mitogen-activated protein kinase by a PKC-dependent pathway in human keratinocytes, Biochem. Biophys. Res. Commun. 208, 245.
19. Miyasaka, J., T. Miyasaka and K. Hayashi, 1992, Two forms of microtubule-associated protein kinase are commonly involved in signal transduction pathways induced by various growth factors, J. Clin. Biochem. Nutr. 12, 1.
20. Mordret, G., 1993, MAP kinase kinase: a node connecting multiple pathways, Biol. Cell 79, 193.
21. mapk are required for fibroblast proliferation, Proc. Natl. Acad. Sci. USA 90, 8319.
22. Pang, L., S.J. Decker and A.R. Saltiel, 1993, Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells, Biochem. J. 289, 283.
23. Racchi, M., S. Bergamaschi, S. Govoni, W.C. Wetsel, A. Bianchetti, G. Binetti, F. Battaini and M. Trabucchi, 1994, Characterization and distribution of protein kinase C isoforms in human skin fibrobiasts, Arch. Biochem. Biophys. 314, 107.
24. Sarber, R., B. Hull, C. Merrill, T. Soranno and E. Bell, 1981, Regulation of proliferation of fibroblasts of low and high population doubling levels grown in collagen lattices. Mech. Ageing Dev. 17, 107.
25. Selbie, L.A., C. Schmitz-Peiffer, Y. Sheng and T. Biden, 1993, Molecular cloning and characterization of PKCi, an atypical isoform of protein kinase C derived from insulin-secreting cells, J. Biol. Chem. 268, 24296.
26. Toullec, D., P. Pianetti, H. Coste, P. Bellevergue, T. Grand-Perret, M. Ajakane, V. Baudet, P. Boissin, E. Boursier, F. Loriolle, L. Duhamel, D. Charon and J. Kirilovsky, 1991, The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C, J. Biol. Chem. 266, 15771.
27. Welham, M.J., V. Duronio, J.S. Sanghera, S.L. Pelech and J.W. Schrader, 1992, Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members, J. Immunol. 149, 1683.
28. Zhou, G., M.W. Woolen and E.S. Coleman, 1994, Regulation of atypical C-protein kinase C in cellular signalling, Exp. Cell Res. 214, 1.