K-ras codon 12 and 61 point mutations in bromodeoxyuridine- and N-nitrosomethylurea-induced rat renal mesenchymal tumors

Cancer Letters

Volumn 109, Issue 1-2, 1996, Pages 1-7

  Calvert, Richard J ^a   Buzard, Gregory S ^b   Anisimov, Vladimir N ^c   Rice, Jerry M ^d  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b SAIC FREDERICK INC   (United States)

^c N N PETROV RESEARCH INSTITUTE OF ONCOLOGY   (Russian Federation)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Bromodeoxyuridine; K ras; N nitrosomethylurea; Polymerase chain reaction; Renal mesenchymal tumors

Indexed keywords

BROXURIDINE; METHYLNITROSOUREA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL CARCINOGENESIS; CODON; CONTROLLED STUDY; FEMALE; KIDNEY TUMOR; MALE; MESENCHYMOMA; MUTATION RATE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT;

ADENINE; ANIMALS; BROMODEOXYURIDINE; CARCINOGENS; CODON; FEMALE; GENES, RAS; GUANINE; KIDNEY NEOPLASMS; MALE; MESENCHYMOMA; METHYLNITROSOUREA; NEOPLASMS, EXPERIMENTAL; POINT MUTATION; POLYMERASE CHAIN REACTION; RATS;

EID: 0030568069     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(96)04350-9     Document Type: Article

References (22)

1. [1] Kresnak, M.T. and Davidson, R.L. (1991) Effects of flanking base sequences on 5-bromodeoxyuridine mutagenesis in mammalian cells, Somat. Cell Mol. Genet., 17, 399-410.
2. [2] Rotstein, J.B., Kresnak, M.T., Samadashwily, G.M. and Davidson, R.L. (1992) Analysis of sequence specificity of 5-bromodeoxyuridine-induced reversion in cells containing multiple copies of a mutant gpt gene, Somat. Cell Mol. Genet., 18, 179-188.
3. [3] Anisimov, V.N. and Osipova, G.Y. (1992) Effect of neonatal exposure to 5-bromo-2′ deoxyuridine on life span, estrus function, and tumor development in rats: an argument in favor of the mutation theory of aging?, Mutat. Res., 275, 97-110.
4. [4] Napalkov, N.P., Anisimov, V.N., Likhachev, A.J. and Tomatis, L. (1989) 5-Bromodeoxy-uridine-induced carcinogenesis and its modification by persistent estrus syndrome, unilateral nephrectomy, and X-irradiation in rats, Cancer Res., 49, 318-323.
5. [5] Osipova, G.Yu. and Anisimov, V.N. (1992) Carcinogenesis induced by neonatal injection of 5-bromo-2′-deoxyuridine and subsequent treatment with N-nitrosomethylurea in rats (in Russian), Vopr. Onkol., 38, 195-204.
6. [6] Anisimov, V.N., Pliss, G.B., Iogannsen, M.G., Popovich, I.G., Romanov, K.P., Monakhov, A.S. and Averyanova, T.K. (1989) Spontaneous tumors in outbred LIO rats, J. Exp. Clin. Cancer Res., 8, 251-262.
7. [7] Higinbotham, K.G., Rice, J.M., Diwan, B.A., Kasprazak, K.S., Reed, C.D. and Perantoni, A.O. (1992) GGT to GTT transversions in codon 12 of the K-ras oncogene in rat renal sarcomas induced with nickel subsulfide or nickel subsulfide/ iron are consistent with oxidative damage to DNA, Cancer Res., 52, 4747-4751.
8. [8] Sukumar, S., Perantoni, A., Reed, C., Rice, J.M. and Wenk, M.L. (1986) Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine, Mol. Cell. Biol., 6, 2716-2720.
9. [9] Innis, M.A., Gelfand, D.H., Sninsky, J.J. and White, J.J. (Editors) (1990) PCR Protocols: a Guide to Methods and Applications, pp. 155-156. Academic Press, San Diego, CA.
10. [10] Chou, Q., Russell, D.E., Birch, J., Raymond, J. and Bloch, W. (1992) Prevention of pre-PCR mispriming and primer dimerization improves low-copy-number amplifications, Nucleic Acids Res., 20, 1717-1723.
11. [11] Higinbotham, K.G., Rice, J.M. and Perantoni, A.O. (1992) Activating point mutation in Ki-ras codon 63 in a chemically induced rat renal tumor, Mol. Carcinogenesis, 5, 136-139.
12. [12] Higinbotham, K.G., Rice, J.M., Buzard, G.S. and Perantoni, A.O. (1994) Activation of the K-ras gene by insertion mutations in chemically induced rat renal mesenchymal tumors, Oncogene, 9, 2455-2459.
13. [13] Perantoni, A.O., Higinbotham, K.G., Reed, C.D., Watatani, M., Enomoto, T., Anderson, L. and Rice, J.M. (1996) Heterogeneity and multiple mutational activation of K-ras oncogene in renal mesenchymal tumors induced in newborn F344 rats by methyl(methoxymethyl)nitrosamine. (Submitted.).
14. [14] Sukumarz, S. and Barbacid, M. (1990) Specific patterns of oncogene activation in transplacentally induced tumors, Proc. Natl. Acad. Sci. USA, 87, 718-722.
15. [15] Ohgaki, H., Kleihues, P. and Hard, G.C. (1991) K-ras mutations in spontaneous and chemically induced tumors of the rat, Mol. Carcinogenesis, 4, 455-459.
16. [16] Zarbl, H., Sukumar, S., Arthur, A.V., Martin-Zanca, D. and Barbacid, M. (1985) Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats, Nature, 315, 382-385.
17. [17] Kumar, R., Sukumar, S. and Barbacid, M. (1990) Activation of ras oncogenes preceding the onset of neoplasia, Science, 248, 1101-1104.
18. [18] Ronai, Z., Lau, Y. and Cohen, L.A. (1991) Dietary N-3 fatty acids do not affect induction of Ha-ras mutations in mammary glands of NMU-treated rats, Mol. Carcinogenesis, 4, 120-128.
19. [19] Zhang, R., Haag, J.D. and Gould, M.N. (1990) Reduction in the frequency of activated ras oncogenes in rat mammary carcinomas with increasing N-methyl-N-nitrosourea doses or increasing prolactin levels, Cancer Res., 50, 4286-4290.
20. [20] Sakai, H. and Ogawa, K. (1991) Mutational activation of c-Ha-ras genes in intraductal proliferation induced by N-nitroso-N-methylurea in rat mammary glands, Int. J. Cancer, 49, 140-144.
21. [21] Ohgaki, H., Hard, G.C., Hirota, N., Maekawa, A., Takahaslli, M. and Kleihues, P. (1992) Selective mutation of codons 204 and 213 of the p53 gene in rat tumors induced by alkylating N-nitroso compounds, Cancer Res., 52, 2995-2998.
22. [22] Chiodino, C., Jones, R.F. and Ethier, S.P. (1991) The role of Ha-ras in growth factor independence in rat mammary carcinoma cells, Mol. Carcinogenesis, 4, 286-296.