Dose-response relationship for rat liver DNA damage caused by 1,2-dimethylhydrazine

Toxicology

Volumn 114, Issue 2, 1996, Pages 113-124

  Kitchin, Kirk T ^a   Brown, Janice L ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

1,2 Dimethylhydrazine; Alkaline elution; Chemical carcinogenesis; DNA damage; Dose response; Risk assessment

Indexed keywords

1,2 DIMETHYLHYDRAZINE;

ANIMAL EXPERIMENT; ARTICLE; CANCER RISK; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; FEMALE; LIVER; NONHUMAN; PRIORITY JOURNAL; RAT; RISK ASSESSMENT;

1,2-DIMETHYLHYDRAZINE; ADMINISTRATION, ORAL; ANIMALS; CARCINOGENS; DIMETHYLHYDRAZINES; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LINEAR MODELS; LIVER; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

ANIMALIA; SIGMOIDEA;

EID: 0030566904     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(96)03478-6     Document Type: Article

References (18)

1. BELLE Newsletter (1995) Dose-response studies of genotoxic rodent carcinogens: thresholds, hockey sticks, hormesis or straight lines? BELLE (Biological Effects of Low Level Exposures, Northeast regional environmental public health center, University of Massachusetts, Amherst, MA) Newsletter 3, 1-19.
2. Cohen, S.M. and Ellwein, L.B. (1990a) Cell proliferation in carcinogenesis. Science 249, 1007-1011.
3. Cohen, S.M. and Ellwein, L.B. (1990b) Proliferative and genotoxic cellular effects in 2-acetlyaminoifluorene bladder and liver carcinogenesis. Biological modeling of the ED01 study. Toxicol. Appl. Pharmacol. 104, 79-93.
4. Diwan, B.A., Meier, H. and Blackman, K.E. (1977) Genetic differences in the induction of colorectal tumors by 1,2-dimethylhydrazine in inbred mice. J. Natl. Cancer Inst. 59, 455-458.
5. Farmer, J.H., Kodell, R.L., Greenman, D.L. and Shaw, G.W. (1979) Dose and time response models for the incidence of bladder and liver neoplasms in mice fed 2-acetlyaminofluorene continuously. J. Environ. Pathol. Toxicol. 3, 55-68.
6. Fiala, E. (1977) Investigation into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane. Cancer 40, 2436-2445.
7. Hawks, A. and Magee, P.N. (1974) The alkylation of nucleic acids of rat and mouse in vivo by the carcinogen 1,2-dimethylhydrazine. Br. J. Cancer 30, 440-447.
8. Jukes, T.H. (1983) Chasing a receding zero. Impact of the zero threshold concept on actions of regulatory officials, In: J.A. CiCino, H.B. Demopoulos, M. Kushner, H. Uehleke, B.L. Van Duuren, B.M. Wagner and V.R. Young (Eds), Cancer and the Environment, Mary Ann Liebert Publishers, New York, pp. 147-160.
9. Kitchin, K.T. and Brown, J.L. (1989) Biochemical effects of three carcinogenic chlorinated methanes in rat liver. Teratogen. Carcinogen. Mutagen. 9, 61-69.
10. Kitchin, K.T. and Brown, J.L. (1994) Dose-response relationship for rat liver DNA damage caused by 49 rodent carcinogens. Toxicology 88, 31-49.
11. Kitchin, K.T., Brown, J.L. and Kulkarni, A.P. (1992) Predictive assay for rodent carcinogenicity using in vivo biochemical parameters. Operational characteristics and complementarity. Mutat. Res. 266, 253-272.
12. Moolgavkar, S. H. (1986) Carcinogenesis modeling. From molecular biology to epidemiology. Annu. Rev. Public Health 7, 151-169.
13. National Toxicology Program (1990) Toxicology and carcinogenesis studies of amosite asbestos in F344/N rats. N.T.P. TR 279, NIH Publication No. 91-2535, pp. 193-198.
14. NIOSH, 1976 Registry of Toxic Effects of Chemical Substances, Stock No. 017-033-00166-9, US Printing Office, HEW No. 76-191, p. 596.
15. 6-methylguanine by alkylation of rat liver, colon, and kidney DNA following administration of 1,2-dimethylhydrazine. Cancer Res. 37, 4082-4087.
16. Uehleke. H. (1983) Thresholds in acute and long tern animal studies. In: J.A. CiCino, H.B. Demopoulos, M. Kushner, H. Uehleke. B.L. Van Duuren, B.M. Wagner and V.R. Young (Eds), Cancer and the Environment, Mary Ann Liebert Publishers, New York, pp. 245-268.
17. Upton, A.C. (1989) The question of thresholds for radiation and chemical carcinogenesis. Cancer Invest. 7, 267-276.
18. Zeise, L., Wilson, R. and Crouch, E.A.C. (1987) Dose-response relationships for carcinogens. A review. Environ. Health Perspect. 73, 259-308.