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2. For lead references on the "copper-effect" in palladium-catalyzed cross-coupling reactions, see: Allred, G. D.; Liebeskind, L. S. J. Am. Chem. Soc. 1996, 118, 2748.
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3. Edwards, J. P.; Krysan, D. J.; Liebeskind, L. S. J. Am. Chem. Soc. 1993, 115, 9868, and references cited therein.
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5. Cone, M. C.; Melville, C. R.; Gore, M. P.; Gould, S. J. J. Org. Chem. 1993, 58, 1058.
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Cone, M.C.1
Melville, C.R.2
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Gould, S.J.4
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8
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0011820804
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Eur. Pat. Appl. EP 304,400, 22 Feb 1989, CH Appl. 87/3, 196, 20 Aug 1987
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6. Isolation: Fendrich, G.; Zimmermann, W.; Gruner, J.; Auden, J. A. L. Eur. Pat. Appl. EP 304,400, 22 Feb 1989, CH Appl. 87/3, 196, 20 Aug 1987; Chem. Abstr. 1990, 112, 75295q.
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Fendrich, G.1
Zimmermann, W.2
Gruner, J.3
Auden, J.A.L.4
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9
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4244188461
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6. Isolation: Fendrich, G.; Zimmermann, W.; Gruner, J.; Auden, J. A. L. Eur. Pat. Appl. EP 304,400, 22 Feb 1989, CH Appl. 87/3, 196, 20 Aug 1987; Chem. Abstr. 1990, 112, 75295q.
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0026001391
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7. (a) Ayer, S. W.; McInnes, A. G.; Thibault, P.; Walter, J. A.; Doull, J. L.; Pamell, T.; Vining, L. C, Tetrahedron Lett. 1991, 32, 6301.
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McInnes, A.G.2
Thibault, P.3
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(b) Doull, J. L.; Ayer, S. W.; Singh, A. K.; Thibault, P. J. Antibiot. 1993, 46, 869.
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Ayer, S.W.2
Singh, A.K.3
Thibault, P.4
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0000205248
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8. The first total synthesis of 1 proceeded in 18 steps from 2,5-dimethylphenol (ca. 4% overall yield): (a) Gore, M. P.; Gould, S. J.; Weller, D. D. J. Org. Chem. 1991, 56, 2289.
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0026638092
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(b) Gore, M. P.; Gould, S. J.; Weller, D. D. J. Org. Chem. 1992, 57, 2774.
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9. (a) Nakajima, S.; Kojiri, K.; Suda, H.; Okanishi, M. J. Antibiot. 1991, 44, 1061.
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Antibiot.
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0011894371
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Eur. Pat. Appl. EP 381,138, Aug 1990
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(b) Suda, K.; Kojiri, K.; Okura, A.; Funaishi, K.; Kawamura, K.; Okanishi, M. Eur. Pat. Appl. EP 381,138, Aug 1990; Chem. Abstr. 1991, 114, 141615p.
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0011826022
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(b) Suda, K.; Kojiri, K.; Okura, A.; Funaishi, K.; Kawamura, K.; Okanishi, M. Eur. Pat. Appl. EP 381,138, Aug 1990; Chem. Abstr. 1991, 114, 141615p.
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0019160930
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10. (a) Ikushima, H.; Iguchi, E.; Kohsaka, M.; Aoki, H.; Imanaka, H. J. Antibiot. 1980, 33, 1103.
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Ikushima, H.1
Iguchi, E.2
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Aoki, H.4
Imanaka, H.5
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18
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0019168737
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(b) Ikushima, H.; Okamaoto, M.; Tanaka, H.; Ohe, O.; Kohsaka, M.; Aoki, H.; Imanaka, H. J. Antibiot. 1980, 33, 1107.
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Ikushima, H.1
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Aoki, H.6
Imanaka, H.7
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19
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0011894373
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note
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+, 100).
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20
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0011862293
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note
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+, 100).
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23
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0011906333
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note
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2, 23 °C, 2 h, 85%.
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24
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0011890591
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note
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2, 23 °C, 2 h, 76%.
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25
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0011823314
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note
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2, reflux, 24 h, 80%.
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26
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0011901106
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note
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16. Colorless oil. Satisfactory spectroscopic and analytical data were obtained for stannanes 8a-b and 12.
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28
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0011889589
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note
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+, 70), 379 (100).
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30
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0011906837
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note
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+, 100).
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31
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0011822392
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note
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+, 100).
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33
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0011890592
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note
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2.
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