Pharmacological potency and biodisposition of phencyclidine via inhalation exposure in mice

Drug and Alcohol Dependence

Volumn 43, Issue 1-2, 1996, Pages 13-22

  Meng, Yun ^a   Lichtman, Aron H ^a   Bridgen, D Troy ^a   Martin, Billy R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Inhalation; Inverted screen test; Phencyclidine; Rotorod test; Volatilization

Indexed keywords

PHENCYCLIDINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISPOSITION; DRUG POTENCY; HEATING; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PYROLYSIS; SMOKING; VOLATILIZATION;

ADMINISTRATION, INHALATION; ANIMALS; AROUSAL; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAVENOUS; MALE; MICE; MICE, INBRED ICR; MOTOR SKILLS; MUSCULOSKELETAL EQUILIBRIUM; PHENCYCLIDINE; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0030566789     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0376-8716(96)01284-7     Document Type: Article

References (28)

1. Balster, R.L. (1980) The effects of phencyclidine and three analogues on motor performance in mice. Pharmacology 20, 46-51.
2. Balster, R.L. (1987) The behavioral pharmacology of phencyclidine. In: Psychopharmacology: The Third Generation of Progress (Meltzer H.Y., ed.), pp. 1573-1579. Raven, New York.
3. Cook, C.E., Brine, D.R., Jeffcoat, A.R., Hill, J.M., Quin, G.D., Perez-Reyes, M. and Di Guiseppi, S.R. (1982 a) Phencyclidine disposition after intravenous and oral doses. Clin. Pharmacol. Ther. 31, 625-634.
4. Cook, C.E., Brine, D.R., Quin, G.D., Perez-Reyes, M. and Di Guiseppi, S.R. (1982b) Phencyclidine and phenylcyclohexene disposition after smoking phencyclidine. Clin. Pharmacol. Ther. 31, 635-641.
5. Cook, C.E., Brine, D.R., Quin, G.D., Wall, M.E., Perez-Reyes, M. and Di Guiseppi, S.R. (1981) Smoking of phencyclidine: disposition in man and stability to pyrolytic conditions. Life Sci. 29, 1967-1972.
6. Cook, C.E.; Jeffcoat, A.R.; and Perez-Reyes, M. (1985) Pharmacokinetic studies of cocaine and phencyclidine in man. In: Pharmacokinetics and Pharmacodynamics of Psychoactive Drugs (Barnett, G. and Chiang, C.N., eds.), pp. 48-74. Biomedical Publications, Foster City, CA.
7. Coughenour, L.L.; McClean, J.R.; and Parker, R.B. (1977) A device for rapid measurement of impaired motor function in mice. Pharmacol. Biochem. Behav. 6, 351-353.
8. D'Amour, F.E. and Smith, D.L. (1941) A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72, 74-70.
9. Freeman, A.S. and Martin, B.R. (1981) Quantitation of phencyclidine in main stream smoke and identification of 1-phenylcyclohexene as pyrolysis product. J. Pharmaceut. Sci. 70, 1002-1004.
10. Freeman, A.S. and Martin, B.R. (1982) Disposition of phencyclidine in mice after smoking exposure. Drug Metab. Dispos. 10, 680-684.
11. Freeman, A.S., Martin, B.R., and Balster, R.L. (1984) Relationship between the development of behavioral tolerance and the biodisposition of phencyclidine in mice. Pharmacol. Biochem. Behavior 20, 373-377.
12. Herber, R., Perrin, R., Ziegler, J.M., Villoutreix, J., Minn, A. and Siest, G. (1991) Identification of novel phencyclidine metabolites formed in vitro by rabbit microsomal metabolism. Xenobiotica 21, 1493-1499.
13. Holsztynska, E.J. and Domino, E.F. (1985) Biotransformation of phencyclidine. Drug Metab. Rev. 16, 285-320.
14. Law, F.C.P. (1989) Metabolic disposition and irreversible binding of phencyclidine in rats. Toxicol. Appl. Pharmacol. 57, 263-272.
15. Lichtman, A.H., Meng, Y. and Martin, B.R. (1996) Inhalation exposure to volatilized opioids produces antinociception in mice. J. Pharmacol. Exp. Ther. (in press).
16. Lue, L.P., Scimeca, J.A., Thomas, B.F. and Martin, B.R. (1986) Identification and quantification of phencyclidine pyrolysis products formed during smoking. J. Anal. Toxicol. 10, 81-86.
17. Martin, B.R. and Boni, J. (1990) Pyrolysis and inhalation studies with phencyclidine and cocaine. In: Research Findings on Smoking of Abused Substances. National Institute on Drug Abuse Research Monograph Series 99. DHHS Pub. No. (ADM)90-1690 (Chiang, C.N. and Hawks, R.L., eds.), pp. 141-158. Supt. of Docs., US Govt. Print. Off., Washington DC.
18. Martin, B.R. and Freeman, A.S. (1983) Disposition of phencyclidine and its pyrolytic products in mice exposed to smoke. Fed. Proc. 42, 2561-2565.
19. Martin, B.R., Lue, L.P. and Boni, J.P. (1989) Pyrolysis and volatilization of cocaine. J. Anal. Toxicol. 13, 158-162.
20. Meng, Y., Lichtman, A.H., Bridgen, D.T., and Martin, B.R. (1996) Inhalation studies with drugs of abuse. National Institute on Drug Abuse Research Monograph Series (in press).
21. Misra, A.L., Pontani, R.B., and Bartolomeo, J.G. (1979) Persistence of phencyclidine (PCP) and metabolites in the brain and adipose tissue and implications for long-lasting behavioral effects. Res. Commun. Chem. Pathol. Pharmacol. 24, 431-445.
22. Perrin, R., Minn, A., and Siest, G. (1988) Interaction of cytochromes P-450 with a reactive metabolit: phencyclidine. In: Cytochrome P-450: Biochemistry and Biophysics (I. Schuster, ed.), pp. 150-153. Taylor and Francis, London.
23. Scaros, L.P., Westra, S., and Barone, J.A. (1990) Illegal use of drugs: a current review. US Pharmacist 15, 17-39.
24. Snyder, S.H. (1980) Phencyclidine, Nature (London) 285, 355-356.
25. Tallarida, R.J. and Murray, R.B. (1987) Manual of Pharmacologic Culculations with Computer Programs, Springer-Verlag, New York.
26. Trevor, A.J., Hoag, M.K.P., Schmith-Peetz, M. and Castagnoli, N., Jr. (1988) Phencyclidine metabolism: involvement of minimum ion intermediate in covalent binding, suicide inactivation of cytochrome P-450 and formation of a novel metabolite. In: Sigma and Phencyclidine-like Compounds as Molecular Probes in Biology (Domino, E. and Kamenka, J.M., eds.), pp. 643-651. Ann Arbor Science Publishers, Ann Arbor, MI.
27. Walther, B., Ghersi-Egea, J.F., Minn, A. and Siest, G. (1986) Subcellular distribution of cytochrome P-450 in the brain. Brain Res. 375, 338-344.
28. Wesson, D.R. and Washburn, P. (1990) Current Patterns of drug abuse that involve smoking. In: Research Findings on Smoking of Abused Substances. National Institute on Drug Abuse Research Monograph Series 99. DHHS Pub. No. (ADM)90-1690 (Chiang, C.N. and Hawks, R.L., eds.), pp. 5-11. Supt. of Docs., US Govt. Print. Off., Washington DC.