DNA damage induced by etoposide; a comparison of two different methods for determination of strand breaks in DNA

Cancer Letters

Volumn 105, Issue 2, 1996, Pages 153-159

  Walles, Solveig A S ^a   Zhou, Rong ^b   Liliemark, Eva ^b  

^a NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cellular drug concentrations; CEM cells; DNA strand breaks; Etoposide

Indexed keywords

DNA; ETOPOSIDE; PROTEINASE;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA DENATURATION; DNA DETERMINATION; DNA STRAND BREAKAGE; DRUG DNA INTERACTION; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHATIC LEUKEMIA; PRIORITY JOURNAL;

EID: 0030565011     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04266-8     Document Type: Article

References (23)

1. [1] Ahnström, G. and Erixon, K. (1973) Radiation induced strand breakage in DNA from mammalian cells. Strand separation in alkaline solution. Int. J. Radiat. Biol., 23, 285-289.
2. [2] Ahnström, G. and Erixon, K. (1981) Measurement of strand breaks by alkaline denaturation and hydroxyapatite chromatography. In: DNA Repair, A Laboratory Manual of Research Procedures, pp. 403-418. Editors: E.C. Friedberg and P.C. Hanawalt. Marcel Dekker, New York.
3. [3] Brunborg, G., Holme, J.A. and Hongslo, J.K. (1995) Inhibitory effects of paracetamol on DNA repair in mammalian cells. Mutat. Res., 342, 157-170.
4. [4] Brunborg, G., Holme, J.A., Söderlund, E.J. and Dybing, E. (1990) Organ-specific genotoxic effects of chemicals: the use of alkaline elution to detect DNA damage in various organs of in vivo-exposed animals. In: Mutation and the Environment. Part D: Carcinogenesis, pp. 43-52. Editors: M.L. Mendehlson and R.J. Albertini. Wiley-Liss, New York.
5. [5] Brunborg, G., Holme, J.A., Söderlund, E.J., Omichinski, J. G. and Dybing, E. (1988) An automated alkaline elution system: DNA damage induced by 1,2-dibromo-3-chloropropane in vivo and in vitro. Anal. Biochem., 174, 522-536.
6. [6] Cesarone, C.F., Bolognesi, C. and Santi, L. (1979) Improved microfluorometric DNA determination in biological material using 33258 Hoechst. Anal. Biochem., 100, 188-197.
7. [7] Erixon, K. and Ahnström, G. (1979) Single-strand breaks in DNA during repair of UV-induced damage in normal human and Xeroderma pigmentosum cells as determined by alkaline DNA unwinding and hydroxylapatite chromatography. Mutat. Res., 59, 257-271.
8. [8] Fleming, R., Miller, A. and Stewart, C. (1989) Etoposide: an update. Clin. Pharm., 8, 274-293.
9. [9] Kohn, K.W. (1979) DNA as a target in cancer chemotherapy: measurement of macromolecular DNA damage produced in mammalian cells by anticancer agents and carcinogens. In: Methods in Cancer Research, pp. 291-345. Academic Press, New York.
10. [10] Kohn, K.W. and Ewig, R.A.G. (1979) DNA-protein crosslinking by trans-platinum(II)diamminedichloride in mammalian cells, a new method of analysis. Biochim. Biophys. Acta, 562, 32-40.
11. [11] Kohn, K.W. and Grimek-Ewig, R.A. (1973) Alkaline elution analysis, a new approach to the study of DNA single-strand interruptions in cells. Cancer Res., 33, 1849-1853.
12. [12] Liliemark, E., Pettersson, B., Peterson, C. and Liliemark, J. (1995) High performance liquid chromatography with fluorometric detection for monitoring of etoposide and its cis-isomer in plasma and leukemic cells. J. Chromatogr. B., in press.
13. [13] Liliemark, E.K., Liliemark, J., Peterson, B., Gruber, A., Björkholm, M. and Peterson, C. (1993) In vivo accumulation of etoposide in peripheral leukemic cells in patients treated for acute myeloblastic leukemia; relation to plasma concentrations and protein binding. Leuk. Lymphoma, 10, 323-328.
14. [14] Liliemark, J., Knochenhauer, E., Gruber, A., Pettersson, B., Björkholm, M. and Peterson, C. (1993) On the interaction between cytosine arabinoside and etoposide in vivo and in vitro. Eur. J. Haematol., 50, 22-25.
15. [15] Long, B.H. (1992) Mechanisms of action of teniposide (VM-26) and comparison with etoposide (VP-16). Semin. Oncol., 19 (Suppl. 6), 3-19.
16. [16] Long, B.H., Musial, S.T. and Brattain, M.G. (1985) Single-and double-strand DNA breakage and repair in human lung adenocarcinoma cells exposed to etoposide and teniposide. Cancer Res., 45, 3106-3112.
17. [17] Long, B.H. and Stringfellow, D.A. (1988) Inhibitors of topoisomerase II: structure-activity relationships and mechanism of podophyllin congeners. In: Advances in Enzyme Regulation, pp. 223-256. Editor: G. Weber. Pergamon, New York.
18. [18] Long, H.B., Musial, S.T. and Brattain, M.G. (1986) DNA breakage in human lung carcinoma cells and nuclei that are naturally sensitive or resistant to etoposide and teniposide. Cancer Res., 46, 3809-3816.
19. [19] Maanen, J.M.S., Retèl, J.J.d.v. and Pinedo, H.M. (1988) Mechanism of action of antitumor drug etoposide: a review, J. Natl. Cancer Inst., 80, 1526-1533.
20. [20] Mans, D.R.A., Lafleur, M.V.M., Westmijze, E.J., van Maanen, J.M.S., van Schaik, M.A., Lankelma, J. and Retèl, J. (1991) Formation of different reaction products with single-and double-stranded DNA by the ortho-quinone and the semi-quinone free radical of etoposide (VP-16-213). Biochem. Pharm., 42, 2131-2139.
21. [21] Stadtmauer, E., Cassileth, P. and Gale, R. (1989) Etoposide in leukemia, lymphoma and bone marrow transplantation. Leuk. Res, 13, 639-650.
22. [22] Walles, S.A.S. and Erixon, K. (1984) Single-strand breaks in DNA of various organs of mice induced by methyl methane sulfonate and dimethylsulfoxide determined by the alkaline unwinding technique. Carcinogenesis, 5, 319-323.
23. [23] Wozniak, A.J. and Ross, W.E. (1983) DNA damage as a basis for 4′-demethylepipodophyllotoxin-9-(4,6-O-ethyliden-β-D-glucopyranoside) (etoposide) cytotoxicity. Cancer Res., 43, 120-124.