Effect of the protein kinase C inhibitor GF 109 203X on elastase release and respiratory burst of human neutrophils

General Pharmacology

Volumn 27, Issue 8, 1996, Pages 1409-1414

  Cabanis, A ^a   Gressier, B ^a   Brunet, C ^a   Dine, T ^a   Luyckx, M ^a   Cazin, M ^a   Cazin, J C ^a  

^a UNIV LILLE   (France)

Author keywords

elastase; human neutrophils; proteins kinase C inhibitor; reactive oxygen species

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; BISINDOLYLMALEIMIDE; CALCIMYCIN; CALCIUM; CALCIUM IONOPHORE; DIOCTANOIN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; LEUKOCYTE ELASTASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; ZYMOSAN;

ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME RELEASE; EXOCYTOSIS; HUMAN; HUMAN CELL; LEUKOCYTE FUNCTION; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; RESPIRATORY BURST;

CALCIMYCIN; CALCIUM; ENZYME INHIBITORS; EXOCYTOSIS; HUMANS; INDOLES; L-LACTATE DEHYDROGENASE; LEUKOCYTE ELASTASE; MALEIMIDES; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PROTEIN KINASE C; RESPIRATORY BURST; SUPEROXIDES; TETRADECANOYLPHORBOL ACETATE;

EID: 0030561593     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00053-5     Document Type: Article

References (40)

1. Aruoma O. L., Halliwell B., Hoey B. M. and Butler J. (1989) The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide and hypochlorous acid. Free Rad. Biol. Med. 6, 593-597.
2. Baggiolini M., Bouley F., Badwey J. A. and Curnutte J. T. (1993) Activation of neutrophil leukocytes: chemoattractant receptors and respiratory burst. FASEB J. 7, 1004-1010.
3. Birchall A. M., Bishop J., Bradshaw D., Cline A., Coffey J., Elliott L. H., Gibson V.M., Greenham A., Hallam T. J., Harris W., Hill C. H., Hutchings A., Lamont A.G., Lawton G., Lewis E. J., Maw A., Nixon J. S., Pole D., Wadsworth J. and Wilkinson S. E. (1994) Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J. Pharmac. Exp. Ther. 268, 922-929.
4. Bonser R. W., Thompson N. T., Randall R. W. and Garland L. G. (1989) Phospholipase D activation is functionally linked to superoxide generation in the human neutrophils. Biochem. J. 264, 617-620.
5. Bradshaw D., Hill C. H., Nixon J. S. and Wilkinson S. E. (1993) Therapeutic potential of protein kinase C inhibitors. Agents Actions 38, 135-147.
6. Cabanis A., Gressier B., Lebègue S., Dine T., Brunet C., Luyckx M., Cazin M. and Cazin J. C. (1993) Effects in vitro of mesna on the production of some reactive oxygen species by human neutrophils. Pharm. Pharmac. Lett. 2, 236-239.
7. Cabanis A., Gressier B., Legègue S., Brunet C., Dine T., Luyckx M., Cazin M. and Cazin J. C. (1994) A rapid density gradient technique for separating polymorphonuclear granulocytes. APMIS 102, 119-121.
8. Clark R. A., Volpp B. D., Leidal K. G. and Nauseef W. M. (1990) Two cytosolic components of the human neutrophil respiratory hurst oxidase translocate to the plasma membrane during cell activation. J. Clin. Invest. 85, 714-721.
9. Cochrane C. G. (1991) Cellular injury by oxidants. Am. J. Med. 91(suppl. 3C), 23-30.
10. Cohen H. J. and Chovaniex R. E. (1978) Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for continuous assay for monitoring superoxide production and for the study of the activation of the generating system. J. Clin. Invest. 61, 1081-1087.
11. Combadière C., Hakim J., Giroud J. P. and Périanin A. (1990) Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor. Biochim. Biophys. Res. Commun. 168, 65-70.
12. Dana R., Malech H. L. and Levy R. (1994) The requirement for phospholipase A2 for activation of the assembled NADPH oxidase in human neutrophils. Biochem. J. 297, 217-223.
13. Dewald B., Thelen M., Wymann M. P. and Baggiolini M. (1989) Staurosporine inhibits the respiratory burst and induces exocytosis in human neutrophils. Biochem. J. 264, 879-884.
14. 2 system and on human leukocyte elastase. Int. J. Pharma. 104, 151-156.
15. Hallam T. J. (1993) Functional significance of protein kinase C in human T-cell activation: a new therapeutic class? Clin. Exp. Rheumatol. 11, S131-S134.
16. Harris W., Hill C. H., Lewis E. J., Nixon J. S. and Wilkinson S. E. (1993) Protein kinase C inhibitors. Drugs Fut. 18, 727-735.
17. Henderson L. M., Chappell J. B. and Jones O. T. G. (1989) Superoxide generation is inhibited by phospholipase A2 inhibitors. Biochem. J. 264, 249-255.
18. Heyworth P. G., Curnutte J. T., Nauseef W. M., Volpp B. D., Pearson D. W., Rosen H. and Clark R. A. (1991) Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. J. Clin. Invest. 87, 352-356.
19. Hoidal J. R. and Niewoehner D.E. (1983) Pathogenesis of emphysema. Chest 83, 679-685.
20. Iwamura H., Moore A. R. and Willoughby D. A. (1993) Interaction between neutrophil-derived elastase and reactive oxygen species in cartilage degradation. Biochim. Biophys. Acta 1156, 295-301.
21. Kessels G. C. R., Roos D. and Verhoeven A. J. (1991) fMet-Leu-Phe-induced activation of phospholipase D in human neutrophils. J. Biol. Chem. 266, 23152-23156.
22. Kessels C. G. R., Krause K. H. and Verhoeven A. J. (1993) Protein kinase C activity is not involved in N-formylmethionyl-leucyl-phenylalanine-induced phospholipase D activation in human neutrophils, but is essential for concomitant NADPH oxidase activation: studies with a staurosporine analogue with improved selectivity for protein kinase C. Biochem. J. 292, 781-785.
23. Kokot K., Teschner M., Shaefer R. M. and Heiland A. (1987) Stimulation and inhibition of elastase release from human neutrophils dependent on the calcium messenger system. Miner. Electrolyte Metab. 13, 133-140.
24. Maridonneau-Parini I., Trigale S. M. and Tauber A. I. (1986) Identification of distinct activation pathways of the human neutrophil NADPH-oxidase. J. Immunol. 137, 2925-2929.
25. 2 enzymes: regulation and physiological role. Biochem. Pharmac. 48, 1-10.
26. Nakamura S. and Nishizuka Y. (1994) Lipid mediators and protein kinase C activation for the intracellular signaling network. J. Biochem. 115, 1029-1034.
27. 1 proteinase inhibitor inactivators - possible application for antioxidant prevention of emphysema. Arch. Immunol. Ther. Exp. 36, 723-731.
28. Robinson J. M., Heyworth P. G. and Badwey J. A. (1990) Utility of staurosporine in uncovering differences in the signal transduction pathways for superoxide production in neutrophils. Biochim. Biophys. Acta 1055, 55-62.
29. Roos D. (1991) The respiratory burst of phagocytic leucocytes. Drug. Invest. 3, 48-53.
30. - forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function. Biochim. Biophys. Acta 853, 65-89.
31. Sha'afi R. I., White J. R., Molski T. F. P., Shefcyk J., Volpi M., Naccache P. H. and Feinstein M. B. (1983) Phorbol 12-myristate 13-acetate activates rabbit neutrophils without an apparent rise in the level of intracellular free calcium. Biochim. Biophys. Res. Commun. 114, 638-645.
32. Sharma P., Evans A. T., Parker P. J. and Evans F. J. (1991) NADPH-oxidase activation by protein kinase C-isotypes. Biochim. Biophys. Res. Commun. 177, 1033-1040.
33. Smith C. D., Uhing R. J. and Snydennan R. (1987) Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters. J. Biol. Chem. 262, 6121-6127.
34. Thompson N. T., Bonser R. W. and Garland L. G. (1991) Receptor-coupled phospholipase D and its inhibition. Trends Pharmac. Sci. 12, 404-408.
35. Toullec D., Pianetti P., Coste H., Bellevergue P., Grand-Perret T., Ajakane M., Baudet V., Boissin P., Boursier E., Loriolle F., Duhamel L., Charon D. and Kirilovski J. (1991) The bisindolylmaleimide GF 109 203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266, 15771-15781.
36. Twomey B., Muid R. E. and Dale M. M. (1990a) The effect of putative protein kinase C inhibitors K252a and staurosporine, on human neutrophil respiratory burst activated by both receptor stimulation and post-receptor mechanisms. Br. J. Pharmac. 100, 819-825.
37. Twomey B., Muid R. E., Nixon J. S., Sedwick A. D., Wilkinson S. E. and Dale M. M. (1990b) The effect of new potent selective inhibitors of protein kinase C on neutrophil respiratory burst. Biochim. Biophys. Res. Comm. 171, 1087-1092.
38. 1 PI by alveolar inflammatory cells from smoking patients with or without emphysema. Am. Rev. Resp. Dis. 147, 1537-1543.
39. Weiss S. J. (1989) Tissue destruction by neutrophils. N. Engl. J. Med. 320, 365-376.
40. Wilkinson S. E. and Hallam T. J. (1994) Protein kinase C: is its pivotal role in cellular activation over-stated? Trends Pharmac. Sci. 15, 53-57.