-
1
-
-
0011952336
-
-
Technical Brochure, UK
-
Anonymous, (1992) EPILIM®, Technical Brochure, UK.
-
(1992)
EPILIM®
-
-
-
2
-
-
0026724498
-
Metabolism of valproate to hepatotoxic intermediates
-
Baillie T. A. (1992) Metabolism of valproate to hepatotoxic intermediates. Pharm. Weekbl. Sci. 14, 122-125.
-
(1992)
Pharm. Weekbl. Sci.
, vol.14
, pp. 122-125
-
-
Baillie, T.A.1
-
3
-
-
0017598681
-
Evidence for an intrastriatal GABAergic influence on dopamine neurons of cat
-
Bartholini G. and Stadler H. (1977) Evidence for an intrastriatal GABAergic influence on dopamine neurons of cat. Neuropharmacology 16, 343-347.
-
(1977)
Neuropharmacology
, vol.16
, pp. 343-347
-
-
Bartholini, G.1
Stadler, H.2
-
4
-
-
0020354815
-
Comparative study of exthosuximide and sodium valproate in the treatment of typical absence seizures (Petitimal)
-
Callaghan N., O'Hare J., O'Driscoll D., O'Neill B. and Daly M. (1982) Comparative study of exthosuximide and sodium valproate in the treatment of typical absence seizures (Petitimal). Dev. Med. Child. Neurol. 24, 830-836.
-
(1982)
Dev. Med. Child. Neurol.
, vol.24
, pp. 830-836
-
-
Callaghan, N.1
O'Hare, J.2
O'Driscoll, D.3
O'Neill, B.4
Daly, M.5
-
5
-
-
0002845381
-
Lipid derived autocoids: Eicosanoids and platelet activation factors
-
(Edited by Gilman A. G., Rall T. W., Nies A. S. and Taylor P.) 8th ed. Pergamon Press, New York
-
Campbell W. B. (1991) Lipid derived autocoids: Eicosanoids and platelet activation factors. In: The Pharmacological Basis of Therapeutics. (Edited by Gilman A. G., Rall T. W., Nies A. S. and Taylor P.) 8th ed. Pergamon Press, New York, pp. 600-617.
-
(1991)
The Pharmacological Basis of Therapeutics.
, pp. 600-617
-
-
Campbell, W.B.1
-
6
-
-
0023769281
-
Comparison of monotherapy with valproate and other antiepileptic drugs, in the treatment of seizure disorders
-
Chadwick D. (1988) Comparison of monotherapy with valproate and other antiepileptic drugs, in the treatment of seizure disorders. Am. J. Med. 84 (Suppl.1A), 3-6.
-
(1988)
Am. J. Med.
, vol.84
, Issue.SUPPL.1A
, pp. 3-6
-
-
Chadwick, D.1
-
7
-
-
0020262762
-
Mechanism of anticonvulsant action of valproate
-
Chapman A., Keane P. E., Meldrum B. S., Simiand J. and Vernieres J. C. (1982) Mechanism of anticonvulsant action of valproate. Prog. Neurobiol. 19, 315-359.
-
(1982)
Prog. Neurobiol.
, vol.19
, pp. 315-359
-
-
Chapman, A.1
Keane, P.E.2
Meldrum, B.S.3
Simiand, J.4
Vernieres, J.C.5
-
8
-
-
0020373487
-
Sodium valproate monotherapy and polytherapy
-
Covanis A; Gupta A. K. and Jeavons P. M. (1982) Sodium valproate monotherapy and polytherapy. Epilepsia 23, 693-720.
-
(1982)
Epilepsia
, vol.23
, pp. 693-720
-
-
Covanis, A.1
Gupta, A.K.2
Jeavons, P.M.3
-
9
-
-
0002549033
-
Studies of neurotransmitter actions (GABA, glycin and convulsants)
-
(Edited by Ward A. A. Jr., Penry J. K. and Purpura D.) Raven Press, New York
-
Davidoff R. A. (1983) Studies of neurotransmitter actions (GABA, Glycin and convulsants): In: Epilepsy. (Edited by Ward A. A. Jr., Penry J. K. and Purpura D.) Raven Press, New York, pp. 53-83.
-
(1983)
Epilepsy
, pp. 53-83
-
-
Davidoff, R.A.1
-
10
-
-
0028045747
-
Valproic acid: A reappraisal of its pharmacological properties and clinical efficacy in epilepsy
-
Davis R., Peter H., and McTavish D. (1994) Valproic acid: A reappraisal of its pharmacological properties and clinical efficacy in epilepsy. Drugs 47, 332-372.
-
(1994)
Drugs
, vol.47
, pp. 332-372
-
-
Davis, R.1
Peter, H.2
McTavish, D.3
-
11
-
-
0011956704
-
Vertebrate GABA-receptors; involvement in CNS functions and behavior
-
(Edited by Essman W. B.) Spectrum, New York
-
De Feudis F. V. and Orensanz-Munoz L. M. (1980) Vertebrate GABA-Receptors; Involvement in CNS Functions and Behavior. In: Neurotransmitters, Receptors and Drug Action. (Edited by Essman W. B.) Spectrum, New York, pp. 143-178.
-
(1980)
Neurotransmitters, Receptors and Drug Action
, pp. 143-178
-
-
De Feudis, F.V.1
Orensanz-Munoz, L.M.2
-
12
-
-
0015061262
-
Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine
-
Di-Rosa, M., Giround, J. P. and Willoughby, D. A. (1971) Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J. Path. 104, 15-29.
-
(1971)
J. Path.
, vol.104
, pp. 15-29
-
-
Di-Rosa, M.1
Giround, J.P.2
Willoughby, D.A.3
-
13
-
-
0023135810
-
Valproic acid hepatic fatalities: A restrospective review
-
Dreifuss F. E., Santilli N., Langer D. H., Sweeney K. P., Moline K. A. and Manander K. B. (1987) Valproic acid hepatic fatalities: a restrospective review. Neurology 37, 379-385.
-
(1987)
Neurology
, vol.37
, pp. 379-385
-
-
Dreifuss, F.E.1
Santilli, N.2
Langer, D.H.3
Sweeney, K.P.4
Moline, K.A.5
Manander, K.B.6
-
14
-
-
0018913312
-
Sodium valproate and platelet counts
-
Eastham R. D. and Jancar J. (1980) Sodium valproate and platelet counts. Bri Med. J. 280, 186.
-
(1980)
Bri Med. J.
, vol.280
, pp. 186
-
-
Eastham, R.D.1
Jancar, J.2
-
15
-
-
0003105626
-
Valproate, mechanism of action
-
(Edited by Levy R., Mattson R., Meldrum B., Penry J. K. and Dreifuss F. E.) 3rd ed. Raven Press Ltd., New York
-
Feriello R., and Smith M. C. (1989) Valproate, mechanism of action. In: Antiepileptic drugs. (Edited by Levy R., Mattson R., Meldrum B., Penry J. K. and Dreifuss F. E.) 3rd ed. Raven Press Ltd., New York, pp. 567-575.
-
(1989)
Antiepileptic Drugs
, pp. 567-575
-
-
Feriello, R.1
Smith, M.C.2
-
16
-
-
0014085887
-
Antiinflammatory activity of several irritants in three models of experimental inflammation in rats
-
Goldstein S., Shemano I., Demeo R. and Beiler J. M. (1967) Antiinflammatory activity of several irritants in three models of experimental inflammation in rats. Arch. Int. Pharmacodyn. 167, 39-53.
-
(1967)
Arch. Int. Pharmacodyn.
, vol.167
, pp. 39-53
-
-
Goldstein, S.1
Shemano, I.2
Demeo, R.3
Beiler, J.M.4
-
17
-
-
0011922701
-
Hyperammonaemia and the use of antiepileptic drugs, including valproate
-
(Edited by Chadwick D.) Royal Society of Medicine Services, London
-
Hulsman J. (1989) Hyperammonaemia and the use of antiepileptic drugs, including valproate. In: Fourth International Symposium on Sodium Valproate and Epilepsy. (Edited by Chadwick D.) Royal Society of Medicine Services, London, pp. 163-168.
-
(1989)
Fourth International Symposium on Sodium Valproate and Epilepsy
, pp. 163-168
-
-
Hulsman, J.1
-
18
-
-
0002277454
-
Analgesic-antipyretic and antiinflammatory drugs; drugs employed in the treatment of rheumatoid arthritis and gout
-
(Edited by Gillman A. G., Rall T. W., Nies A. S. and Taylor P.) 8th ed. Pergamon Press, New York
-
Insel P. A. (1991) Analgesic-antipyretic and antiinflammatory drugs; drugs employed in the treatment of rheumatoid arthritis and gout. In: The Pharmacological Basis of Therapeutics. (Edited by Gillman A. G., Rall T. W., Nies A. S. and Taylor P.) 8th ed. Pergamon Press, New York, pp. 638-681.
-
(1991)
The Pharmacological Basis of Therapeutics
, pp. 638-681
-
-
Insel, P.A.1
-
19
-
-
0001181259
-
Sodium valproate in the treatment of Nelson's syndrome
-
Jones M. T., Altaher A. R. H., Nicholson S. A., Branagan L. M., Campbel E. A. and Gillham B. (1983) Sodium valproate in the treatment of Nelson's syndrome. Symposium Suppl., Br J. Clin. Pract. 27, 142-149.
-
(1983)
Symposium Suppl., Br J. Clin. Pract.
, vol.27
, pp. 142-149
-
-
Jones, M.T.1
Altaher, A.R.H.2
Nicholson, S.A.3
Branagan, L.M.4
Campbel, E.A.5
Gillham, B.6
-
20
-
-
0027973087
-
Severe hepatotoxicity during valproate therapy: An update and report of eight new fatalities
-
Koning S. T. A., Seimes H., Blacker F., Boenikle E., Groß-Selbeck G., Hanefeld F., Haas N., Kohler B., Koelfen W., Korinthenberg R., Kurek E., Lenard H.-G., Penin H-, Penzien J. M. Sehunke W., Schultz C., Stephani U., Stute M., Traus M., Weinmann H.-M. and Scheffiner D. (1994) Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalities. Epilepsia 35, 1005-1015.
-
(1994)
Epilepsia
, vol.35
, pp. 1005-1015
-
-
Koning, S.T.A.1
Seimes, H.2
Blacker, F.3
Boenikle, E.4
Groß-Selbeck, G.5
Hanefeld, F.6
Haas, N.7
Kohler, B.8
Koelfen, W.9
Korinthenberg, R.10
Kurek, E.11
Lenard, H.-G.12
Penin, H.13
Penzien, J.M.14
Sehunke, W.15
Schultz, C.16
Stephani, U.17
Stute, M.18
Traus, M.19
Weinmann, H.-M.20
Scheffiner, D.21
more..
-
21
-
-
0019839152
-
Gamma-aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects
-
Krogsgaard-Larsen P. (1981) Gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J. Med. Chem. 24, 1377-1383.
-
(1981)
J. Med. Chem.
, vol.24
, pp. 1377-1383
-
-
Krogsgaard-Larsen, P.1
-
22
-
-
0000014402
-
Valproic acid (Antiepileptic drugs)
-
(Edited by Frey H. H. and Janz D.). Springer Verlag, Berlin
-
Löscher W. (1985) Valproic acid (Antiepileptic drugs). In: Handbook of Experimental Pharmacology. (Edited by Frey H. H. and Janz D.) Vol. 74. Springer Verlag, Berlin, pp. 507-537.
-
(1985)
Handbook of Experimental Pharmacology
, vol.74
, pp. 507-537
-
-
Löscher, W.1
-
23
-
-
0021944134
-
In vivo effects of aminooxyacetic acid and valproate on nerve terminals (synaptosomal) GABA levels in discrete brain areas of rats
-
Löscher W. and Vetter M. (1985) In vivo effects of aminooxyacetic acid and valproate on nerve terminals (synaptosomal) GABA levels in discrete brain areas of rats. Biochem. Pharmacol. 34, 1747-1756.
-
(1985)
Biochem. Pharmacol.
, vol.34
, pp. 1747-1756
-
-
Löscher, W.1
Vetter, M.2
-
25
-
-
0025648225
-
Carnitine metabolism and morphometric change of liver mitochondria in valproate treated rats
-
Murakami K., Sugimoto T., Nishida N., Woo M., Araki A., Kobayashi Y. and Sakane Y. (1990) Carnitine metabolism and morphometric change of liver mitochondria in valproate treated rats. Neuropediatrics 21, 187-190.
-
(1990)
Neuropediatrics
, vol.21
, pp. 187-190
-
-
Murakami, K.1
Sugimoto, T.2
Nishida, N.3
Woo, M.4
Araki, A.5
Kobayashi, Y.6
Sakane, Y.7
-
26
-
-
0021638232
-
Valproic acid and metabolites: Pharmacological and toxicological studies
-
Nau H. and Löscher W. (1984) Valproic acid and metabolites: Pharmacological and toxicological studies. Epilepsia 25 (Suppl. 1), S14-S22.
-
(1984)
Epilepsia
, vol.25
, Issue.SUPPL. 1
-
-
Nau, H.1
Löscher, W.2
-
27
-
-
0018294145
-
Thrombocytopenia associated with sodium valproate treatment
-
Neophytides A. N., Nutt J. G. and Lodish J. R. (1979) Thrombocytopenia associated with sodium valproate treatment. Ann. Neurol. 5, 389-390.
-
(1979)
Ann. Neurol.
, vol.5
, pp. 389-390
-
-
Neophytides, A.N.1
Nutt, J.G.2
Lodish, J.R.3
-
28
-
-
0019941501
-
Carnitine deficiency and hyperammonaemia associated with valproic acid therapy
-
Ohtani Y., Eudo F. and Matsudo J. (1982) Carnitine deficiency and hyperammonaemia associated with valproic acid therapy. J. Pediatr. 101, 782-785.
-
(1982)
J. Pediatr.
, vol.101
, pp. 782-785
-
-
Ohtani, Y.1
Eudo, F.2
Matsudo, J.3
-
29
-
-
0021253454
-
Controlled and comparative trials with valproate: United States
-
Ramsay R. E. (1984) Controlled and comparative trials with valproate: United States. Epilepsia 25 (Suppl.), S40-S43.
-
(1984)
Epilepsia
, vol.25
, Issue.SUPPL.
-
-
Ramsay, R.E.1
-
30
-
-
0002968868
-
Alterations in the functions of nucleus locus coeruleus: A possible model for studies of anxiety
-
(Edited by Hanin I. and Usdin E.) Pergamon Press, Oxford
-
Redmond D. E. (1977) Alterations in the functions of nucleus locus coeruleus: A possible model for studies of anxiety. In: Animal Models of Psychiatry and Neurology. (Edited by Hanin I. and Usdin E.) Pergamon Press, Oxford, pp. 293-304.
-
(1977)
Animal Models of Psychiatry and Neurology
, pp. 293-304
-
-
Redmond, D.E.1
-
32
-
-
0018574580
-
Interaction between sodium valproate and platelets: A further study
-
Sandler R. M., Bevan P. C. Roberts G. E. Emberson C., Voak D., Darnborough J. and Heeley A. F. (1979a) Interaction between sodium valproate and platelets: A further study. Br. Med. J. 2, 1476.
-
(1979)
Br. Med. J.
, vol.2
, pp. 1476
-
-
Sandler, R.M.1
Bevan, P.C.2
Roberts, G.E.3
Emberson, C.4
Voak, D.5
Darnborough, J.6
Heeley, A.F.7
-
33
-
-
0018237527
-
IgM platelet antibody due to sodium valproate
-
Sandler R. M., Emberson C., Roberts G. E., Voak D., Darnborough J. and Heeley A. F. (1979b) IgM platelet antibody due to sodium valproate. Br. Med. J. 2, 1683-1684.
-
(1979)
Br. Med. J.
, vol.2
, pp. 1683-1684
-
-
Sandler, R.M.1
Emberson, C.2
Roberts, G.E.3
Voak, D.4
Darnborough, J.5
Heeley, A.F.6
-
34
-
-
0020061174
-
Valproic acid versus ethosuximide in the treatment of absence seizures
-
Sato S., White B., Penry J. K., Dreifuss F. E., Sackellares J. C. and Kupferberg H. (1982) Valproic acid versus ethosuximide in the treatment of absence seizures. Neurology. 32, 153-163.
-
(1982)
Neurology
, vol.32
, pp. 153-163
-
-
Sato, S.1
White, B.2
Penry, J.K.3
Dreifuss, F.E.4
Sackellares, J.C.5
Kupferberg, H.6
-
36
-
-
0025262113
-
Changes in T and B lymphocyte proliferative responses in adjuvant-arthritic rats; antagonism by indomethacin
-
Seng G. F., Benensohn J. and Bayer B. M. (1990) Changes in T and B lymphocyte proliferative responses in adjuvant-arthritic rats; antagonism by indomethacin. Eur. J. Pharmacol. 178, 267-273.
-
(1990)
Eur. J. Pharmacol.
, vol.178
, pp. 267-273
-
-
Seng, G.F.1
Benensohn, J.2
Bayer, B.M.3
-
37
-
-
0023222128
-
Heatotoxicity in rats following administration of valproic acid: Effects of L-carnitine supplementation
-
Sugimoto T., Araki A., Nishida N., Sakane Y., Woo M., Takeuchi T. and Kabayashi Y. (1987) Heatotoxicity in rats following administration of valproic acid: Effects of L-carnitine supplementation. Epilepsia 28, 373-377.
-
(1987)
Epilepsia
, vol.28
, pp. 373-377
-
-
Sugimoto, T.1
Araki, A.2
Nishida, N.3
Sakane, Y.4
Woo, M.5
Takeuchi, T.6
Kabayashi, Y.7
-
38
-
-
0023951776
-
1 L-carnitine on valaproate induced hyperammonaemia and hypoketonaemia in primary cultured hepatocytes
-
1 L-carnitine on valaproate induced hyperammonaemia and hypoketonaemia in primary cultured hepatocytes. Biochem. Pharmacol. 37, 2255-2258.
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 2255-2258
-
-
Takeuchi, T.1
Sugimoto, T.2
Nishida, N.3
Kobayashi, Y.4
-
39
-
-
0026538606
-
Amelioration of adverse effects of valproic acid on ketogenesis and liver Co-enzyme a metabolism by co-treatment with pentothenate and carnitine in developing mice: Possible clinical significance
-
Thurston J. H. and Hauhart R. E. (1992) Amelioration of adverse effects of valproic acid on ketogenesis and liver Co-enzyme A metabolism by co-treatment with pentothenate and carnitine in developing mice: possible clinical significance. Pediat. Res. 31, 419-423.
-
(1992)
Pediat. Res.
, vol.31
, pp. 419-423
-
-
Thurston, J.H.1
Hauhart, R.E.2
-
42
-
-
0023694740
-
Review of valproate monotherapy in the treatment of generalised tonic-clinic seizures
-
Wilder B. J. and Ranjel R. J. (1988) Review of valproate monotherapy in the treatment of generalised tonic-clinic seizures. Am. J. Med. 84 (Suppl. 1A), 7-13.
-
(1988)
Am. J. Med.
, vol.84
, Issue.SUPPL. 1A
, pp. 7-13
-
-
Wilder, B.J.1
Ranjel, R.J.2
-
43
-
-
67249094291
-
Carrageenan induced oedema in hind paw of the rats as an assay for antiinflammatory drugs
-
Winter C. A., Risley E. A. and Nuss G. W. (1962) Carrageenan induced oedema in hind paw of the rats as an assay for antiinflammatory drugs. Proc. Soc. Exp. Biol. Med. 111, 544-547.
-
(1962)
Proc. Soc. Exp. Biol. Med.
, vol.111
, pp. 544-547
-
-
Winter, C.A.1
Risley, E.A.2
Nuss, G.W.3
-
44
-
-
0023818975
-
B receptor sites involved in rat thermoregulation
-
B receptor sites involved in rat thermoregulation. Gen. Pharmac. 19, 223-226.
-
(1988)
Gen. Pharmac.
, vol.19
, pp. 223-226
-
-
Zarrindast, M.R.1
Oveissi, Y.2
|