Inhibition of NO synthase induction by an anticancer drug 4'-epi-doxorubicin in rats

General Pharmacology

Volumn 27, Issue 8, 1996, Pages 1367-1372

  Sakai, Toyohiko ^a   Muramatsu, Ikunobu ^b   Hayashi, Nobushige ^a   Ishii, Yasushi ^a  

^a Department of Radiology ^*  (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

Author keywords

4' epi doxorubicin; anthrocycline derivatives; nitric oxide (NO); NO synthase induction

Indexed keywords

ACETYLCHOLINE; ANTINEOPLASTIC AGENT; ARGININE; CITRULLINE; EPIRUBICIN; LIPOPOLYSACCHARIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; RADIOISOTOPE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG HOMOGENATE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION; THORACIC AORTA;

ACETYLCHOLINE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; AORTA, THORACIC; ARGININE; CEREBELLUM; CITRULLINE; ENDOTHELIUM, VASCULAR; ENZYME INDUCTION; EPIRUBICIN; LIPOPOLYSACCHARIDES; LUNG; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE; RATS; RATS, WISTAR;

EID: 0030561384     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00076-6     Document Type: Article

References (27)

1. Andrade S. P., Bakhle Y. S. and Piper P. J. (1991) Decreased response to platelet activating factor, endothelin-1 and angiotensin II in tumour blood vessels mice. Br. J. Pharmacol. 104, 422P.
2. Andrade S. P., Hart I. R. and Piper P. J. (1992) Inhibitors of nitric oxide synthase selectively reduce flow in tumour-associated neovasculature. Br. J. Pharmacol 107, 1092-1095.
3. Azuma H., Ishikawa M. and Seizaki S. (1986) Endothelium-dependent inhibition of platelet aggregation. Br. J. Pharmacol. 88, 411-415.
4. Billar T. R., Curran R. D., Stuehr D. J., Staldler J., Simians R. L. and Murray S. A. (1990) Inducible cytosolic enzyme activity for the producing of nitrogen oxides from L-arginine in hepatocytes. Biochem. Biophys. Res. Commun. 168, 1034-1040.
5. Buttery L. D. K., Springall D. R., Andrade S. P., Riveros M. V., Piper P. J. and Polak J. M. (1993) Induction of nitric oxide synthase in the neo-vasculature of experimental tumors in mice. J. Pathol. 171, 311-319.
6. Casazza A. M. (1979) Experimental evaluation of anthracycline analogs. Cancer. Treat. Rep. 63, 835-844.
7. Dasan L., and Steven R. V. (1994) Inhibition of nitric oxide synthase by antineoplastic anthrocyclines. Biochem. Pharmacol. 47, 2111-2112.
8. Di Marco A. (1975) Adriamycine; mode and mechanism of action. Cancer Chemother. Rep. Part 3, 6, 91-106.
9. Di Rosa M., Radomski M., Carnuccio R. and Moncada S. (1990) Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem. Biophys. Res. Commun. 172, 1246-1252.
10. Djeu J. Y., Blanchard D. K., Halkias D. and Friedman H. (1986) Growth inhibition of Candida albicans by human polymorphonuclear neutrophils; activation by interferon-gamma and tumor necrosis factor. J. Immunol. 137, 2980-2984.
11. Ganzina F. (1983) 4′-Epi-doxorubicine, a new analogue of doxorubicine: a preliminary overview of preclinical and clinical data. Cancer Treat. Rev. 10, 1-22.
12. 2+. Biochem. J. 270, 351-356.
13. Knowles R. G., Merrett M., Salter M. and Moncada S. (1990a) Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem. J. 270, 833-836.
14. Knowles R. G., Salter M., Brooks S. L. and Moncada S. (1990b) Antiinflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat. Biochem. Biophys. Res. Commun. 172, 1042-1048.
15. Kumaratilake L. M., Ferrante A. and Rzepczyk C. (1991) The role of T lymphocytes in immunity to plasmodium falciparm. enhancement of neutrophil-mediated parasite killing by lymphotoxin and IFN-gamma; comparisons with tumor necrosis factor effects. J. Immunol. 146, 762-767.
16. Liew F. Y. and Cox F. E. G. (1991) Nonspecific defense mechanism: the role of nitric oxide. Immunol. Today 12, A17.
17. Moncada S. and Higgs A. (1993) The L-arginine-nitric oxide pathway. N. Engl. J. Med. 30, 2002-2012.
18. Nakamura H., Hashimoto T., Oi H. and Sawada S. (1989) Transcatheter oily chemoembolization of hepatocellular carcinoma. Radiology 170, 783-786.
19. Radomski M., Palmer R. M. J. and Moncada S. (1987a) Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacycline in platelets. Br. J. Pharmacol. 92, 181-187.
20. Radomski M., Palmer R. M. J. and Moncada S. (1987b) The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem. Biophys. Res. Commun. 148, 1482-1489.
21. Rogers N. E. and Ignarro L. J. (1992) Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine. Biochem. Biophys. Res. Commun. 189, 242-249.
22. 2+-independent nitric oxide synthases. FEBS Lett. 291, 145-149.
23. Soldani G. (1981) The effects of antiadrenergic and antihistaminic drugs on ECG alternations induced by anthracyclines in rats. Drugs Exptl. Clin. Res. 7, 31-36.
24. Takakura K., Goto Y., Kigoshi S. and Muramatsu I. (1994) Comparison between the effects of treatment in vitro and in vivo with lipopolysaccharide on responsiveness of rat thoracic aorta. Circ. Shock 42, 141-146.
25. Thiemermann C. and Vane J. (1992) Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. Eur. J. Pharmacol. 182, 591-595.
26. Uchida H., Ohishi H., Matsuo N., Nishimine K., Ohue S., Nishimura Y., Maeda M. and Yoshioka T. (1990) Transcatheter hepatic segmental arterial embolization using lipiodol mixed with an anticancer drug and gel-foam particles for hepatocellular carcinoma. Cardiovasc. Intervent. Radiol. 13, 140-145.
27. Wei X., Charles I. G., Smith A., Ure J., Feng G., Huang F., Xu D., Muller W., Moncada S. and Liew F. Y. (1995) Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 375, 408-411.