Comparison of the protective effect of (R)-α-methylhistamine and its prodrugs on gastric mucosal damage induced by ethanol in the rat

General Pharmacology

Volumn 27, Issue 8, 1996, Pages 1391-1394

  Morini, Giuseppina ^a   Grandi, Daniela ^a   Bertaccini, Giulio ^a  

^a UNIVERSITY OF PARMA   (Italy)

Author keywords

(R) methylhistamine; azomethine prodrugs; ethanol; gastroprotection; rat

Indexed keywords

ALCOHOL; ALPHA METHYLHISTAMINE; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOLOGY; INTRAGASTRIC DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH MUCOSA LESION; STOMACH PROTECTION;

ANIMALS; ETHANOL; GASTRIC MUCOSA; GASTROINTESTINAL HEMORRHAGE; HISTAMINE AGONISTS; MALE; METHYLHISTAMINES; NECROSIS; PRODRUGS; RATS; RATS, WISTAR;

EID: 0030561243     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00068-7     Document Type: Article

References (7)

1. 3-receptor ligands on various biochemical indices of histaminergic neuron activity in rat brain. Eur. J. Pharmac. 164, 1-11.
2. Holzer P. and Lippe I. T. (1988) Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of gastric mucosa. Neuroscience 27, 981-987.
3. Krause M., Stark H., Luger P., Garbarg M., Rouleau A., Schwartz J. C. and Schunack W. (1994) Targeted drug delivery of (R)-α-methylhistamine, XXIII Annual Meeting of the European Histamine Research Society, Budapest, Hungary, May 18-21.
4. 3 receptors? Digestion 56, 145-152.
5. Morini G., Grandi D. and Bertaccini G. (1995b) Stimulation of gastric acid secretion by (R)-α-methylhistamine in the rat: influence of the increased gastric juice volume on ethanol-induced lesions. Inflamm. Res. 44, S106-S107.
6. 3-receptor agonists and antagonists. Eur. J. Drug. Metab. Pharmacokinet. 3, 173-178.
7. 3-receptor agonist, in rats. J. Pharm. Pharmac. 46, 371-374.