Acute amitriptyline treatment produces non-opioid-mediated analgesia in the formalin and bee venom tests

Pathophysiology

Volumn 3, Issue 4, 1996, Pages 227-231

  Fuchs, Perry N ^a,b   Lariviere, William R ^a   Balinsky, Melissa ^a   Melzack, Ronald ^a  

^a MCGILL UNIVERSITY   (Canada)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amitriptyline; Antinociception; Bee venom; Formalin

Indexed keywords

AMITRIPTYLINE; BEE VENOM; ENDORPHIN; FORMALDEHYDE; NALOXONE;

ANALGESIA; ARTICLE; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT;

EID: 0030560690     PISSN: 09284680     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4680(96)00018-1     Document Type: Article

References (23)

1. [1] Onghena, P. and Van Houdenhove, B. (1992) Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies. Pain 49, 205-219.
2. [2] Ziegler, D.K., Hurwitz, A., Hassanein, R.S., Kodanaz, H.A., Preskorn, S.H. and Mason, J. (1987) Migraine prophylaxis: a comparison of propranolol and amitriplyline. Arch. Neurol. 44, 486-489.
3. [3] Sharav, Y., Singer, E., Schmidt, E., Dionne, R.A. and Dubner, R. (1987) The analgesic effect of amitriptyline on chronic facial pain. Pain 31, 199-209.
4. [4] Watson, C.P., Evans, R.J., Reed, K., Merskey, H., Goldsmith, L. and Warsh, J. (1982) Amitriptyline versus placebo in postherpetic neuralgia. Neurology 32, 671-673.
5. [5] Max, M.B., Culnane, M., Schafer, S.C., Gracely, R.H., Warmer, D.J., Smoller, B. and Dubner, R. (1987) Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood. Neurology 37, 589-596.
6. [6] Leijon, G. and Boivie, J. (1989) Central post-stroke pain - a controlled trial of amitriptyline and carbamazepine. Pain 36, 27-36.
7. [7] Abad, F., Feria, M. and Boada, J. (1989) Chronic amitriptyline decreases autotomy following dorsal rhizotomy in rats. Neurosci. Lett. 99, 187-190.
8. [8] Seltzer, Z., Tal, M. and Sharav, Y. (1989) Autotomy behavior in rats following peripheral deafferentation is suppressed by daily injections of amitriptyline, diazepam and saline. Pain 37, 245-250.
9. [9] Butler, S.H., Weil-Fugazza, J., Godefroy, F. and Besson, J.M. (1985) Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis. Pain 23, 159-175.
10. [10] Tura, B. and Tura, S.M. (1990) The analgesic effect of tricyclic antidepressants. Brain Res. 518, 19-22.
11. [11] Ventafridda, V., Bianchi, M., Ripamonti, C., Sacerdote, P., De Conno, F., Zecca, E. and Panerai, A.E. (1990) Studies on the effects of antidepressant drugs on the antinociceptive action of morphine and on plasma morphine in rat and man. Pain 43, 155-162.
12. [12] Acton, J., McKenna, J.E. and Melzack, R. (1992) Amitriptyline produces analgesia in the formalin pain test. Exp. Neurol. 117, 94-96.
13. [13] Ortega-Alvaro, A., Gibert-Rahola, J., Chover, A.J., Tejedor-Real, P., Casas, J. and Mico, J.A. (1994) Effect of amitriptyline on the analgesia induced by adrenal medullary tissue transplanted in the rat spinal subarachnoid space as measured by an experimental model of acute pain. Exp. Neurol. 130, 9-14.
14. [14] Messing, R.B. and Lytle, L.D. (1977) Serotonin-containing neurons: their possible role in pain and analgesia. Pain 4, 1-21.
15. [15] Besson, J.M. and Chaouch, A. (1987) Peripheral and spinal mechanisms of nociception. Physiol. Rev. 67, 67-186.
16. [16] Sicuteri, F., Anselmi, B. and Fanciullacci, M. (1974) The serotonin (5-HT) theory of migraine. Adv. Neurol. 4, 383-394.
17. [17] Raiteri, M., Del Carmine, R., Cervoni, A.M. and Levi, G. (1979) Differential binding of antidepressants to noradrenaline and serotonin transport sites in central nerve endings. Eur. J. Pharmacol. 57, 407-416.
18. [18] Baldessarini, R.J. (1990) Drugs and the treatment of psychiatric disorders. In: ed. A.G. Gilman, T.W. Rall, A.S. Nies and P. Taylor, Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th Ed. Pergamon Press, New York, pp. 383-435.
19. [19] Magni, G. (1991) The use of antidepressants in the treatment of chronic pain: a review of the current evidence. Drugs 42, 730-748.
20. [20] De Felipe, M.C., De Ceballos, M.L. and Fuentes, J.A. (1986) Hypoalgesia induced by antidepressants in mice: a case for opioids and serotonin. Eur. J. Pharmacol. 125, 193-199.
21. [21] Hamon, M., Gozlan, H., Bourgoin, S., Benoliel, J.J., Mauborgne, A., Taquet, H., Cesselin, F. and Mico, J.A. (1987) Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline. Neuropharmacology 26, 531-539.
22. [22] Dubuisson, D. and Dennis, S.G. (1977) The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 4, 161-174.
23. [23] Lariviere, W.R. and Melzack, R. (in press) The bee venom test: a new tonic-pain test. Pain.