Pulmonary arterial endothelial dysfunction potentiates hypercapnic vasoconstriction and alters the response to inhaled nitric oxide

Annals of Thoracic Surgery

Volumn 62, Issue 6, 1996, Pages 1677-1684

  Myers, Jeff L ^a   Wizorek, Joseph J ^a   Myers, Adam K ^a   Yankah, Ekua ^a   Pettit, Maria T ^a   Kouretas, Peter C ^a   Dalton, Heidi J ^a   Wang, Yining ^a   Hopkins, Richard A ^a,b  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N(G) NITROARGININE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; HYPERCAPNIA; INHALATIONAL DRUG ADMINISTRATION; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; SWINE; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION;

ADMINISTRATION, INHALATION; ANIMALS; ANIMALS, NEWBORN; BLOOD PRESSURE; CARBON DIOXIDE; ENDOTHELIUM, VASCULAR; HYPERCAPNIA; NITRIC OXIDE; NITROARGININE; OXYGEN; PULMONARY ARTERY; SWINE; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 0030558235     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(96)00678-9     Document Type: Article

References (28)

1. 1. Stamler JS, Loh E, Roddy M, Currie KE, Creager MA. Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 1994;89:2035-40.
2. 2. Van Camp JR, Yian C, Lupinetti FM. Regulation of pulmonary vascular resistance by endogenous and exogenous nitric oxide. Ann Thorac Surg 1994;58:1025-30.
3. 3. Nelin LD, Dawson CA. The effect of Nω-nitro-L-arginine methylester on hypoxic vasoconstriction in the neonatal pig lung. Pediatr Res 1993;34:349-53.
4. 4. Etches PC, Finer NN, Barrington KJ, Graham AJ, Chan WKY. Nitric oxide reverses hypoxic pulmonary hypertension in the newborn piglet. Pediatr Res 1994;35:15-9.
5. 5. Puybassett L, Stewart T, Rouby J, et al. Inhaled nitric oxide reverses the increase in pulmonary vascular resistance induced by permissive hypercapnia in patients with acute respiratory distress syndrome. Anesthesiology 1994;80:1254-67.
6. 6. Greenwald SE, Johnson RJ, Haworth SJ. Pulmonary vascular input impedance in the newborn and infant pig. Cardiovasc Res 1984;18:44-50.
7. 7. Fineman JR, Wong J, Morin FC III, Wild LM, Soifer SJ. Chronic nitric oxide inhibition in utero produces pulmonary hypertension in newborn lambs. J Clin Invest 1994;93: 2675-83.
8. 8. Kinsella JP, McQueston JA, Rosenberg AA, Abman SV. Hemodynamic effects of exogenous nitric oxide in ovine transitional pulmonary circulation. Am J Physiol 1992; 263(Heart Circ Physiol 32):H875-80.
9. 9. Rubin LJ. Vasodilator therapy. In: Fishmann AP, ed. The pulmonary circulation: normal and abnormal. Philadelphia: University of Pennsylvania Press, 1990:479-83.
10. 10. Sladen RN. Temperature and ventilation after hypothermic cardiopulmonary bypass. Anesth Analg 1985;64:816-20.
11. CO2 after cardiopulmonary bypass. Anesthesiology 1986;64:311-5.
12. 12. Wessel DL, Adatia I, Giglia TM, Thompson JE, Kulik TJ. Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass. Circulation 1993;88(part 1):2128-38.
13. 13. Dyar O, Young JD, Howell S, Johns E. Dose-dependent relationship for inhaled nitric oxide in experimental pulmonary hypertension in sheep. Br J Anaesth 1993;71:702-8.
14. 14. Watkins DN, Jenkins IR, Rankin J, Clarke GM. Inhaled nitric oxide in severe acute respiratory failure - its use in intensive care and a description of a delivery system. Anesth Intensive Care 1993;6:861-6.
15. 15. DeBono EF, Caro CG. Effect of lung inflating pressure on pulmonary blood pressure and flow. Am J Physiol 1963;205:1178-86.
16. 16. Hopkins RA, Mammon JW Jr, McHale PA, Smith PK, Anderson RW. An analysis of the pulsatile hemodynamic responses of the pulmonary circulation to acute and chronic pulmonary venous hypertension in the awake dog. Circ Res 1980;47:902-10.
17. 17. Womersley JR. Oscillatory flow in arteries: the constrained elastic tube as a model of arterial flow and pulse transmission. Phys Med Biol 1957;2:178-87.
18. 18. Hopkins RA, Bull C, Haworth SG, de Leval MR, Stark J. Pulmonary hypertensive crisis following surgery for congenital heart defects in young children. Eur J Cardiovasc Thorac Surg 1991;5:628-31.
19. 19. Jobes DR, Nicolson SC, Steven JM, Miller M, Jacobs ML, Norwood WI Jr. Carbon dioxide prevents overcirculation in the hypoplastic left heart syndrome. Ann Thorac Surg 1992; 54:150-1.
20. 20. Haworth SG, Hislop AA. Adaptation of the pulmonary circulation to extra-uterine life in the pig and its relevance to the human infant. Cardiovasc Res 1981;15:108-19.
21. 21. Milnor WR, Bergel DH, Bargainer JD Hydraulic power associated with pulmonary blood flow and its relation to heart rate. Circ Res 1966;19:467-80.
22. 22. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6.
23. 23. Zellers TM, Vanhoutte PM. Endothelium-dependent relaxations of piglet pulmonary arteries augment with maturation. Pediatr Res 1991;30:176-80.
24. 24. Abman SH, Chatfield BA, Rodman DM, Hall SL, McMurtry IF. Maturational changes in endothelium-derived relaxing factor activity of ovine pulmonary arteries in vitro. Am J Physiol 1991; 260 Lung Cell Mol Physiol 4:L280-5.
25. 25. Domkowski PW, Cockerham JT, Crescenzo DG, et al. Pulmonary hydraulic impedance responses to hypoxia and hypercapnia in newborn pigs. J Appl Physiol 1994;77:386-96.
26. 26. Chang AC, Zucker HA, Hickey PR, Wessel DL. Pulmonary vascular resistance in infants after cardiac surgery: role of carbon dioxide and hydrogen ion. Crit Care Med 1995;23:568-74.
27. 27. Puybasset L, Stewart T, Rouby J, et al. Inhaled nitric oxide reverses the increase in pulmonary vascular resistance induced by permissive hypercapnia in patients with acute respiratory distress syndrome. Anesthesiology 1994;80: 1254-67.
28. 28. Hammon JW, Smith PK, McHale PA, Vanbenthuysen KM, Anderson RW. Analysis of pulsatile pulmonary flow in the unanesthetized dog. J Appl Physiol 1981;50:805-13.