Analysis of the kinetics of synaptic inhibition points to a reduction in GABA release in area CA1 of the genetically epileptic mouse, El

Epilepsy Research

Volumn 26, Issue 1, 1996, Pages 15-23

  Lambert, John D C ^a   Fueta, Yukiko ^b   Roepstorff, Andreas ^a   Andreasen, Mogens ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

El mouse; epilepsy; GABA(A) receptor inhibition; hippocampus; inhibitory postsynaptic current

Indexed keywords

4 AMINOBUTYRIC ACID; BACLOFEN; CALCIUM; TIAGABINE;

ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; EPILEPSY; HIPPOCAMPUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; ANTICONVULSANTS; BACLOFEN; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; EPILEPSY; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; INTERNEURONS; MICE; MICE, MUTANT STRAINS; NEURAL INHIBITION; NIPECOTIC ACIDS; RECEPTORS, GABA; SPECIES SPECIFICITY; SYNAPTIC TRANSMISSION;

EID: 0030557803     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(96)00035-6     Document Type: Conference Paper

References (28)

1. [1] Dingledine, R., Brain Slices, Plenum Press, New York, London, 1984.
2. [2] Rutecki, P.A. and Johnston, D., The hippocampus and epilepsy. In: S.H. Appel (Ed.), Current Neurology, Vol. 7, Year Book Medical Publishers Inc. Chicago, 1987 pp. 129-157.
3. [3] Schwartzkroin, P.A., Epilepsy: Models, Mechanisms and Concepts, Cambridge University Press, Cambridge, 1993.
4. [4] Jobe, P.C., Mishra, P.K., Ludvig, N. and Dailey, J.W., Genetic models of the epilepsies. In: P.A. Schwartzkroin (Ed.), Epilepsy: Models, Mechanisms and Concepts, Cambridge University Press, Cambridge, 1993, pp. 94-140.
5. [5] McNamara, J.O., Pursuit of the mechanisms of kindling, Trends Neurosci., 11 (1988) 33-36.
6. [6] Seyfried, T.N., Glaser, G.H., Yu, R.K. and Parayoor, S.T., Inherited convulsive disorders in mice. In: A.V. Delgado-Escueta, A.A. Ward, Jr., D.M. Woodbury and R.J. Porter (Eds.), Basic Mechanisms of the Epilepsies: Molecular and Cellular Approaches, Raven Press, New York, 1986, pp. 115-133.
7. [7] Mutoh, K., Ito, M., Tsuda, H., Shiraishi H., Oguro, K., Shirasaka, Y., Okuno, T. and Mikawa, H., Depth EEG in mutant epileptic El Mice: demonstration of secondary generalization of the seizure from the hippocampus, Electroencephalogr. Clin. Neurophysiol., 86 (1993) 205-212.
8. [8] Ishida, N., Kasamo, K., Nakamoto, Y. and Suzuki, J., Epileptic seizure of El mouse initiates at the parietal cortex: depth EEG observation in freely moving condition using buffer amplifier, Brain Res., 608 (1993) 52-57.
9. [9] Fueta, Y., Ono, K. and Mita, T., Enhancement of frequency potentiation in the hippocampal slices of epilepsy-prone El mice, Soc. Neurosci. Abstr., 20 (1994) 171.
10. [10] Hiramatsu, M., Edamatsu, R., Suzuki, S., Shimada, M. and Mori, A., Regional excitatory and inhibitory amino acid levels in epileptic El mouse brain, Neurochem. Res., 15 (1990) 821-825.
11. [11] Murashima, Y.L., Kasamo, K. and Suzuki, J., Developmental abnormalities of GABAergic system are involved in the formation of epileptogenesis in the El, Neurosciences, 18 (Suppl. 2) (1992) 63-73.
12. [12] Roepstorff, A. and Lambert, J.D.C., Factors contributing to the decay of the stimulus-evoked IPSC in rat hippocampal CA1 neurons, J. Neurophysiol., 72 (1994) 2911-2926.
13. [13] Mody, I., de Koninck, Y., Otis, T.S. and Soltesz, I., Bridging the cleft at GABA synapses in the brain, Trends Neurosci., 17 (1994) 517-525.
14. [14] Rekling, J.C., Jahnsen, H. and Laursen, A.M., The effect of two lipophilic gamma-aminobutyric acid uptake blockers in CA1 of the rat hippocampal slice, Br. J. Pharmacol., 99 (1990) 103-106.
15. [15] Roepstorff, A. and Lambert, J.D.C., Comparison of the effect of the GABA uptake blockers, tiagabine and nipecotic acid on inhibitory synaptic efficacy in hippocampal CA1 neurones, Neurosci. Lett., 146 (1992) 131-134.
16. [16] Thompson, S.M. and Gähwiler, B.H., Effects of the GABA uptake inhibitor tiagabine on inhibitory synaptic potentials in rat hippocampal slice cultures, J. Neurophysiol., 67 (1992) 1698-1701.
17. [17] Faingold, C.L., Randall, M.E. and Anderson, C.A.B., Blockade of GABA uptake with tiagabine inhibits audiogenic seizures and reduces neuronal firing in the inferior colliculus of the genetically epilepsy-prone rat, Exp. Neurol., 126 (1994) 225-232.
18. [18] Smith, S.E., Parvez, N.S., Chapman, A.G. and Meldrum, B.S., The gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy, Eur. J. Pharmacol., 273 (1995) 259-265.
19. [19] Walton, N.Y., Gunawan, S. and Treiman, D.M., Treatment of experimental status epilepticus with the GABA uptake inhibitor, tiagabine, Epilepsy Res., 19 (1994) 237-244.
20. [20] Gram, L., Tiagabine: A novel drug with a GABAergic mechanism of action, Epilepsia, 35 (Suppl. 5) (1994) S85-S87.
21. [21] Mengel, H., Tiagabine, Epilepsia, 35 (Suppl. 5) (1994) S81-S84.
22. B receptor-mediated responses by tetrahydroaminoacridine in area CA3 of the rat hippocampus, J. Neurophysiol., 69 (1993) 630-635.
23. B receptor-mediated inhibition of calcium currents and excitatory synaptic transmission in hippocampal neurons in vitro, Neuron, 12 (1994) 97-107.
24. [24] Thompson, S.M. and Gähwiler, B.H., Comparison of the actions of baclofen at pre- and postsynaptic receptors in the rat hippocampus in vitro, J. Physiol. London, 451 (1992) 329-345.
25. [25] Nathan, T. and Lambert, J.D.C., Depression of the fast IPSP underlies paired-pulse facilitation in area CA1 of the rat hippocampus, J. Neurophysiol., 66 (1991) 1704-1715.
26. [26] Thompson, S.M., Modulation of inhibitory synaptic transmission in the hippocampus, Prog. Neurobiol., 42 (1994) 575-609.
27. [27] Edwards, F.A., LTP - a structural model to explain the inconsistencies, Trends Neurosci., 18 (1995) 250-255.
28. [28] Nathan, T., Jensen, M.S. and Lambert, J.D.C., The slow inhibitory postsynaptic potential in rat hippocampal CA1 neurones is blocked by intracellular injection of QX-314, Neurosci. Lett., 110 (1990) 309-313.