Depressed function in remote myocardium after myocardial infarction: Influence of orotic acid

Annals of Thoracic Surgery

Volumn 62, Issue 6, 1996, Pages 1765-1772

  Cochrane, Andrew D ^b   Pathik, Shobhna ^b   Smolich, Joseph J ^b   Conyers, Robert A J ^b   Rosenfeldt, Franklin L ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; ISOPRENALINE; OROTIC ACID; PLACEBO;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOPLEGIA; CONTROLLED STUDY; DOG; HEART FUNCTION; HEART LEFT VENTRICLE FUNCTION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; DOGS; ECHOCARDIOGRAPHY; HEART; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIUM; OROTIC ACID; PROPRANOLOL; VENTRICULAR FUNCTION, LEFT;

EID: 0030550357     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(96)00673-X     Document Type: Article

References (29)

1. 1. DeWood MA, Spores J, Berg R Jr, et al. Acute myocardial infarction: a decade of experience with surgical reperfusion in 701 patients. Circulation 1983;68(Suppl 2):8-16.
2. 2. Newman MA, Chen XZ, Rabinov M, Williams JF, Rosenfeldt FL. Sensitivity of the recently infarcted heart to cardioplegic arrest. Beneficial effect of pretreatment with orotic acid. J Thorac Cardiovasc Surg 1989;97:593-604.
3. 3. Munsch C, Williams JF, Rosenfeldt FL. The impaired tolerance of the recently infarcted rat heart to cardioplegic arrest: the protective effect of orotic acid. J Mol Cell Cardiol 1989;21:751-4.
4. 4. Munsch CM, Rosenfeldt FL, O'Halloran K, Langley LH, Conyers RA, Williams JF. The effect of orotic acid on the response of the recently infarcted rat heart to hypothermic cardioplegia. Eur J Cardiothorac Surg 1991;5:82-93.
5. 5. Yeh T Jr, Rebeyka IM, Jakoi ER, et al. Orotic acid improves left ventricular recovery four days after heterotopic transplantation. Ann Thorac Surg 1994;58:409-15.
6. 6. Richards SM, Fisher JL, Rosenfeldt FL, Conyers RAJ. Cardioprotection by orotic acid: mechanism of action. J Mol Cell Cardiol (in press).
7. 7. Lukomskii PE, Meerson FZ, Soloven W. Disturbances of contractile function of the heart in myocardial infarction and the therapeutic use of cofactors of synthesis and precursors of nucleic acids. Kardiologiia 1967;7:3-11.
8. 8. Zharov EI. Use of co-factors of the synthesis and precursors of nucleic acids in myocardial infarct patients. Kardiologiia 1971;11:15-25.
9. 9. Stajner A, Suva J, Musil F. The determination of orotic acid in the blood serum by means of the spectrophotometric method. Experientia 1968;24:116-7.
10. 10. Ceremuzynski L. Hormonal and metabolic reactions evoked by acute myocardial infarction. Circ Res 1981;48:767-76.
11. 11. Shatney CH, MacCarter DJ, Lillehei RC. Effects of allopurinol, propranolol and methylprednisolone on infarct size in experimental myocardial infarction. Am J Cardiol 1976;37:572-80.
12. 12. Wyatt HL, Forrester JS, da Luz PL, Diamond GA, Chagrasulis R, Swan HJC. Functional abnormalities in nonoccluded regions of myocardium after experimental coronary occlusion. Am J Cardiol 1976;37:366-72.
13. 13. Gillam LD, Franklin TD, Foale RA, et al. The natural history of regional wall motion in the acutely infarcted canine ventricle. J Am Coll Cardiol 1986;7:1325-34.
14. 14. Mann DL, Gillam LD, Mich R, Foale R, Newell JB, Weyman AE. Functional relation between infarct thickness and regional systolic function in the acutely and subacutely infarcted canine left ventricle. J Am Coll Cardiol 1989;14:481-8.
15. 15. Gallagher KP, Gerren RA, Ning XH, et al. The functional border zone in conscious dogs. Circulation 1987;76:929-42.
16. 16. Lieberman AN, Weiss JL, Jugdutt BI, et al. Two-dimensional echocardiography and infarct size: relationship of regional wall motion and thickening to the extent of myocardial infarction in the dog. Circulation 1981;63:739-46.
17. 17. Levy MN, Ng ML, Zieske H. Functional distribution of the peripheral cardiac sympathetic pathways. Circ Research 1966;19:650-61.
18. 18. Homans DC, Asinger R, Elsperger KJ, et al. Regional function and perfusion at the lateral border of ischemic myocardium. Circulation 1985;71:1038-47.
19. 19. Jaarsma W, Visser CA, Eenige van MJ, et al. Prognostic implications of regional hyperkinesia and remote asynergy of noninfarcted myocardium. Am J Cardiol 1986;58:394-8.
20. 20. Theroux P, Ross J Jr, Franklin D, Covell JW, Bloor CM, Sasayama S. Regional myocardial function and dimensions early and late after myocardial infarction in the unanesthetized dog. Circ Res 1977;40:158-65.
21. 21. Sasayama S, Gallagher KP, Kemper WS, Franklin D, Ross J Jr. Regional left ventricular wall thickness early and late after coronary occlusion in the conscious dog. Am J Physiol 1981;240:H293-9.
22. 22. Beyersdorf F, Acar C, Buckberg GD, et al. Studies on prolonged acute regional ischemia. V. Metabolic support of remote myocardium during left ventricular power failure. J Thorac Cardiovasc Surg 1989;98:567-79.
23. 23. Gudbjarnason S, Puri PS, Mathes P. Biochemical changes in non-infarcted heart muscle following myocardial infarction. J Mol Cell Cardiol 1971;2:253-76.
24. 24. Weitbrecht M, Schaper J, Zanker K, Blumel G, Mathes P. Morphology and mitochondrial function of the surviving myocardium following myocardial infarction in the cat. Basic Res Cardiol 1983;78:423-34.
25. 25. Guski H, Kruglova IS, Beloussova TA, Meyer R, Wassilew G. Structure and function of mitochondria of the non-ischaemic heart in myocardial infarction. Ultrastructural, morphometric and quantitative histochemical studies in the rat. Exp Pathol 1981;20:17-25.
26. 26. Corday E, Kaplan L, Meerbaum S, et al. Consequences of coronary arterial occlusion on remote myocardium: effects of occlusion and reperfusion. Am J Cardiol 1975;36:385-94.
27. 27. Baumann G, Riess G, Erhardt WD, et al. Impaired beta-adrenergic stimulation in the uninvolved ventricle post-acute myocardial infarction: reversible defect due to excessive circulating catecholamine-induced decline in number and affinity of beta-receptors. Am Heart J 1981;101:569-81.
28. 28. Applebaum R, House R, Rademaker A, et al. Coronary artery bypass grafting within thirty days of acute myocardial infarction. Early and late results in 406 patients. J Thorac Cardiovasc Surg 1991;102:745-52.
29. 29. Von Segesser LK, Popp J, Amann FW, Turina MI. Surgical revascularization in acute myocardial infarction. Eur J Cardiothorac Surg 1994;8:363-9.