Cortical versus thalamic mechanisms underlying spike and wave discharges in GAERS

Epilepsy Research

Volumn 26, Issue 1, 1996, Pages 37-44

  Avanzini, G ^a   De Curtis, M ^a   Franceschetti, S ^a   Sancini, G ^a   Spreafico, R ^a  

^a Ist Nazionale Neurologico C Besta ^*  (Italy)

Author keywords

idopathic epilepsy model; neocortex; rat; thalamus

Indexed keywords

4 AMINOBUTYRIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR; BACLOFEN;

ABSENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; THALAMUS;

2-AMINO-5-PHOSPHONOVALERATE; 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; EPILEPSY, ABSENCE; GAMMA-AMINOBUTYRIC ACID; NEURAL PATHWAYS; PYRAMIDAL CELLS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTIC TRANSMISSION; THALAMIC NUCLEI; THALAMUS;

EID: 0030540949     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(96)00037-X     Document Type: Conference Paper

References (37)

1. [1] Avanzini, G., de Curtis, M., Panzica, F. and Spreafico, R., Intrinsic properties of nucleus reticularis thalami neurons of the rat studied in vitro, J. Physiol., 416 (1989) 111-122.
2. [2] Avanzini, G., de Curtis, M., Marescaux, C., Panzica, F., Spreafico, R. and Vergnes M., Role of the thalamic reticular nucleus in the generation of rhythmic thalamo-cortical activities subserving spike and waves, J. Neural. Transm. Suppl., 35 (1992) 85-95.
3. [3] Avanzini, G., Vergnes, M., Spreafico, R. and Marescaux, C., Calcium-dependent regulation of genetically determined spike and waves by the reticular thalamic nucleus of rats, Epilepsia, 34 (1993) 1-7.
4. [4] Avanzini G., et al., AMPA-mediated neurotransmission in neocortex of the GAERS model of rodents nonconvulsive generalized epilepsy, submitted.
5. [5] Avoli, M., Feline generalized penicillin epilepsy, Ital. J. Neurol. Sci., 16 (1995) 79-82.
6. [6] Changeaux, J.P. and Danchin, A., Selective stabilization of developing synapses as a mechanism for the specification of neuronal networks, Nature, 264 (1976) 705-712.
7. [7] Chagnac-Amitai, Y. and Connors, B.W., Synchronized excitation and inhibition driven by intrinsically bursting neurons in neocortex, J. Neurophysiol., 62 (1989) 1149-1162.
8. [8] de Curtis, M., Spreafico, R. and Avanzini, G., Excitatory amino acids mediate responses elicited in vitro by stimulation of cortical afferents to reticularis thalami neurons of the rat, Neuroscience, 33 (1989) 275-283.
9. [9] Di Pasquale, E., Keegan, K.D. and Noebels J.L., Increased cortical excitability in the mutant mouse, stargazer, WONOEP Epilepsy Res., this volume.
10. [10] Gloor, P., Electrophysiology of generalized epilepsy. In: P.A. Schwartzkroin and H. Wheal (Eds.), Electrophysiology of epilepsy. Academic Press, London, 1984, pp. 107-136.
11. [11] Gloor, P. and Fariello, R.G., Generalized epilepsy: some of its cellular mechanisms differ from those of focal epilepsy, Trends Neurosci., 11 (1988) 63-68.
12. + current by metabotropic glutamate and muscarinic receptors in rat CA3 cells: mediation by G-protein, J. Physiol., 474 (1994) 27-33.
13. 2+ current in a genetic model of absence epilepsy, Neuroreport, 4 (1993) 1231-1235.
14. [14] Huguenard, J.R. and Prince, D.A., Intrathalamic rhythmicity studied in vitro: normal T current modulation causes robust anti-oscillatory effects, J. Neurosci., 14 (1994) 5485-5502.
15. [15] Jasper, H.H., Historical introduction (with conclusions), In: M. Avoli, P. Gloor, G. Kostopoulos and R. Naquet (Eds.), Generalized epilepsy. Neurobiological approaches, Birkhauser, Boston, 1990, pp. 1-15.
16. [16] Knight, A.R. and Bowery, N.G., GABA receptors in rats with spontaneous generalized non-convulsive epilepsy, J. Neural. Transm. Suppl., 35 (1992) 189-196.
17. [17] Levitt, P. and Noebels, J.L., Mutant mouse tottering: selective increase of locus coeruleus axons in a defined single locus mutation, Proc. Natl. Acad. Sci. USA, 78 (1981) 4630-4634.
18. [18] Llinas, R., The intrinsic electrophysiological properties of mammalian neurons: insight into the central nervous system functions. Science, 242 (1988) 1654-1664.
19. [19] Marescaux, C. and Vergnes, M., Genetic absence epilepsy in rats from Strasbourg (GAERS), Ital. J. Neurol. Sci., 16 (1995) 113-118.
20. [20] Marescaux, C., Vergnes, M. and Depaulis, A., Genetics absence epilepsy in rats from Strasbourg - a review, J. Neural. Transm. Suppl., 35 (1992) 37-69.
21. [21] Mouritzen-Dam, A., Absence-like seizures in rats: total neuron number in the thalamic reticular nucleus, (1996), this volume.
22. [22] Mulle, C., Madariaga, A. and Deschenes, M., Morphology and electrophysiological properties of nRt neurons in the cat: in vivo study of a thalamic pacemaker, J. Neurosci., 6 (1986) 2134-2145.
23. [23] Noebels, J.L., Single locus mutations in mice expressing generalized spike-wave absence epilepsies. Ital. J. Neurol. Sci., 16 (1995) 107-111.
24. [24] Pumain, R., Louvel, J., Gastard, M., Kurcewicz, L. and Vergnes M., Responses to N-methyl-D-aspartate are enhanced in rats with Petit-mal-like seizures, J. Neural Transm. Suppl., 35 (1992) 97-108.
25. [25] Schoepp, D.D. and Conn, P.J., Metabotropic glutamate receptors in brain function and pathology, Trends Pharmacol. Sci., 14 (1993) 13-20.
26. [26] Shatz, C., Impulse activity, the patterning of connections during CNS development, Neuron, 5 (1990) 743-756.
27. [27] Shaw, C., and Lanius, R.A., Cortical AMPA receptors: age-dependent regulation by cellular depolarization and agonist stimulation, Dev. Brain Res., 68 (1992) 225-231.
28. [28] Sillar, K.T., Synaptic specificity: development of locomotor rhythmicity, Curr. Opin. Neurosci, 4 (1994) 101-107.
29. [29] Snead, O.C., Basic mechanisms of generalized absence seizures, Ann. Neurol., 37 (1995) 146-157.
30. [30] Snead, O.C., Banerjee, P.K., Depaulis, A., and Vergnes, M., NMDA receptor complex in experimental absence seizures: an autoradiographic study, Epilepsia, 33 (Suppl. 3) (1992) 33.
31. [31] Snead, O.C., Hechler V., Vergnes, M., Marescaux, C., and Maitre M., Increased gamma-hydroxybutiric acid receptors in thalamus of a genetic animal model of petit mal epilepsy, Epilepsy Res., 7 (1990) 121-128.
32. A receptor impairment in the genetic absence epilepsy rats from Strasbourg (GAERS): an immunocytochemical and receptor binding autoradiographic study, Epilepsy Res., 15 (1993) 229-238.
33. [33] Steriade, M. and Deschenes, M., The thalamus as a neuronal oscillator, Brain Res. Rev., 8 (1984) 1-63.
34. [34] Steriade, M., Dominich, L. and Oakson, G., Reticularis thalami neurons revisited: activity changes during shifts in states of vigilance, J. Neurosci., 6 (1986) 68-81.
35. [35] Steriade, M. and Llinas, R., Functional states of the thalamus and the associated neuronal interplay, Physiol. Rev., 68 (1988) 649-742.
36. [36] Tsakiridou, E., Bertollini, L., de Curtis, M., Avanzini, G. and Pape H.-C., Selective increase in T-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy, J. Neurosci., 15 (1995) 3110-3117.
37. [37] Vergnes, M., Marescaux, C., Depaulis, A., Micheletti, G. and Warter, J.M., Ontogeny of spontaneous petit mal-like seizures in Wistar rats, Dev. Brain Res., 30 (1986) 85-87.