A review of the biology of canine skin with respect to the commensals Staphylococcus intermedius, Demodex canis and Malassezia pachydermatis

Veterinary Dermatology

Volumn 7, Issue 3, 1996, Pages 119-132

  Mason, Ian S ^a   Mason, Kenneth V ^b   Lloyd, David H ^c  

^a Veterinary Dermatology Consultants   (United Kingdom)

^b Albert Animal Hospital   (Australia)

^c ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Commensals; Demodex canis; Demodicosis; Dog; Malassezia pachydermatis; Skin; Staphylococci; Staphylococcus intermedius

Indexed keywords

CANIS; CANIS FAMILIARIS; DEMODEX CANIS; MALASSEZIA PACHYDERMATIS; STAPHYLOCOCCI; STAPHYLOCOCCUS INTERMEDIUS;

EID: 0030516001     PISSN: 09594493     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-3164.1996.tb00237.x     Document Type: Review

References (182)

1. Ihrke, P.J. An overview of bacterial skin disease in the dog. British Veterinary Journal 1987; 143: 112-8.
2. Mason, I.S. Canine pyoderma. Journal of Small Animal Practice 1991; 32: 381-6.
3. Scott, D.W., Miller, W.H., Griffin, C.E. Muller and Kirk's Small Animal Dermatology, 5th edn. Philadelphia: W.B. Saunders Company, 1995: 417-32.
4. Koutz, F.R. Demodex folliculorum studies VI. The internal phase of canine demodectic mange. Journal of the American Veterinary Medical Association 1957; 131: 45-4.
5. Koutz, F.R. Demodex folliculorum studies VII. Speculum 1957; 11: 39-42.
6. Yamane, O., Sako, S. Studies on canine demodicosis. Demodectic mite population in normal dogs. Journal of the Japanese Veterinary Medical Association 1957; 10: 362-5.
7. Kristensen, S., Krogh, H.V. A study of skin diseases in dogs and cats III Microflora of the skin of dogs with chronic eczema. Nordisk Veterinaermedicin 1978; 30: 223-30.
8. Berg, J.N., Wendell, D.E., Vogelweid, C., Fales, W.H. Identification of the major coagulase-positive Staphylococcus sp. of dogs as Staphylococcus intermedius. American Journal of Veterinary Research 1984; 45: 1307-9.
9. Lloyd, D.H., Allaker, R.P., Pattinson, A. Carriage of Staphylococcus intermedius on the ventral abdomen of clinically normal dogs and those with pyoderma. Veterinary Dermatology 1991; 2: 161-4.
10. Dufait, R. Pityrosporum canis as the cause of canine chronic dermatitis. Veterinary Medicine and Small Animal Clinician 1983; 78: 1055-7.
11. Larsson, C.E., Larsson, M.H., Amaral, R.C., Gandra, C.R.P., Hagiwara, M.K., Fernandes, W.R. Dermatitis in dogs caused by Malassezia (Pityrosporum) pachydermatis. Ars Veterinaria 1988; 4: 63-68.
12. Scott, D.W., Miller, W.H. Epidermal dysplasia and Malassezia pachydermatis infection in West Highland White terriers. Veterinary Dermatology 1989; 1: 25-36.
13. Mason, K.V., Evans, A.G. Dermatitis associated with Malassezia pachydermatis in 11 dogs. Journal of the American Animal Hospital Association. 1991; 27: 13-20.
14. Scott, D.W., Walton, D.K. Experiences with the use of amitraz and ivermectin for the treatment of generalised demodicosis in dogs. Journal of the American Animal Hospital Association 1985; 21: 535-541.
15. Bywater, R.J., Hewett, G.R., Marshall, A.B., West, B. Efficacy of clavulanate-potentiated amoxycillin in experimental and clinical skin infections. Veterinary Record 1985; 116: 177-9.
16. Paradis, M., Lemay, S., Scott, D.W., Miller, W.H., Wellington, J., Panich, R. Efficacy of enrofloxacin in the treatment of canine bacterial pyoderma. Veterinary Dermatology 1990; 1: 123-720.
17. Miller, W.H., Scott, D.W. Milbemycin in the treatment of generalised demodicosis in the dog. In: Proceedings of the 7th annual meeting of the American Academy of Veterinary Dermatology and Veterinary Allergy. 1991: 44.
18. Medleau, L., Willemse, T. Efficacy of daily amitraz therapy for generalised demodicosis in dogs: two independent studies. In: Proceedings of the 7th annual meeting of the American Academy of Veterinary Dermatology and Veterinary Allergy. 1991: 41-2.
19. Lloyd, D.H. The inhabitants of the mammalian skin surface. In: Jenkinson, D.M., Roberts, R.J., eds. Proceedings of the Royal Society of Edinburgh. 1980; 79B: 25-42.
20. DeBoer, D.J., Schultz, K.T., Thomas, C.B., Moriello, K.A. Clinical and immunological responses of dogs with recurrent pyoderma to injections of staphylococcus phage lysate. In: von Tscharner, C., Halliwell, R.E.W., eds. Advances in Veterinary Dermatology, Volume 1. London: Bailliere Tindal, 1990: 335-46.
21. DeBoer, D.J. Strategies for management of recurrent pyoderma in dogs. Veterinary Clinics of North America 1991; 20: 1509-24.
22. Marples, R.R., Kligman, A.M. Pyoderma due to resistant Staphylococcus aureus following topical application of neomycin. Journal of Investigative Dermatology 1969; 53: 11-3.
23. Pryjma, J. Heczko, P.B., Wilburg, J. The effect of staphylococcal antagonism on development of infection in experimental animals. Experimental Medical Microbiology 1972; 24: 86-90.
24. Allaker, R.P., Lloyd, D.H., Smith, I.M. Prevention of exudative epidermitis in gnotobiotic piglets by bacterial interference. Veterinary Record 1988; 123: 597-8.
25. Ihrke, P.J., Schwartzman, R.M., McGinley, K., Horowitz, L., Marples, R.R. Microbiology of normal and seborrhoeic canine skin. American Journal of Veterinary Research 1978; 39: 1487-9.
26. Krogh, H.V., Kristensen, S. A study of skin diseases of dogs and cats II Microflora of the normal skin of dogs and cats. Nordisk Veterinaermedicin 1976; 28: 459-63.
27. Hajek, V., Marsalek, E. Evaluation of classificatory criteria for staphylococci. In: Jeljaszewicz, J. ed. Proceedings of the IIIrd International Symposium of Staphylococci and Staphylococcal Infections. 1975: 11-21.
28. Cox, H.U., Newman, S.S., Roy, A.F., Hoskins, J.D. Species of Staphylococcus isolated from animal infections. Cornell Veterinarian 1984; 74: 124-35.
29. Medleau, L., Long, R.E., Brown, J., Miller, W.H. Frequency and antimicrobial susceptibility of Staphylococcus species isolated from canine pyodermas. American Journal of Veterinary Research 1986; 47: 229-31.
30. Hearst, B.R. Low incidence of staphylococcal dermatides in animals with high incidence of Staphylococcus aureus. Part 2: Preliminary study of dogs. Veterinary Medicine and Small Animal Clinician 1967; 62: 541-3.
31. White, S.D., Ihrke, P.J., Stannard, A.A. et al. Occurrence of Staphylococcus attreus on the clinically normal canine hair coat. American Journal of Veterinary Research 1983; 44: 332-4.
32. Devriese, L.A., De Pelsmaecker, K. The anal region as a main carrier site of Staphylococcits intermedius and Streptococcus canis in dogs. Veterinary Record 1987; 121: 302-3.
33. Allaker, R.P, Lloyd, D.H., Simpson, A.I. Occurrence of Staphylococcus intermedius on the skin and hair of normal dogs. Research in Veterinary Science 1992; 52: 174-176.
34. Weidman, F.W. Exfoliative dermatitis in the Indian Rhinoceros, with description of a new yeast species. Pityrosporum pachydermatis. In: Report of the Laboratory Museum of Comparative Pathology of the Zoological Society of Philadelphia 1925; 2: 36-44.
35. Dufait, R. Presence de Malassezia pachydermatis (syn. Pityrosporum canis) sur les poils et les plumes d'animaux domestiques. Bulletin de la Societe Francaise de Mycologie Medicale 1985; 14: 19-22.
36. Rippon, J.W. Medical Mycology. The Pathogenic Fungi and the Pathogenic Actinomycetes. Philadelphia: W.B. Saunders & Co., 1988: 154-68.
37. Lukman, P. Findings of Pityrosporum canis in the organs of healthy and sick dogs. Veterinarski Arhiv 1983; 52: 37-44.
38. Bond, R., Saijonmaa-Koulumies, L.E.M., Lloyd, D.H. Population sizes and frequency of Malassezia pachydermatis at skin and mucosal sites on healthy dogs. Journal of Small Animal Practice 1995; 36: 147-150.
39. Ainsworth, G.C., Austwick, P.K.C. Fungal Disease of Animals, 2nd edn. Commonwealth Agricultural Bureaux, Farnham Royal, UK, 1973.
40. Willard, J. Superficial infections. Medical Mycology, 3rd edn. Philadelphia: W.B. Saunders Co., 1988: 154-167.
41. Gabal, M.A. Preliminary studies on the mechanism of infection and characterization of Malassezia pachydermatis in association with canine otitis externa. Mycopathologia 1988; 104: 93-8.
42. Yarrow, D., Ahearn, D.G. Malassezia Baillon. In: Kreger van Rig, N.J.W. ed. The Yeasts: A Taxonomic Study. Amsterdam: Elsevier Science, 1984: 882-5.
43. Mason, K.V. Cutaneous Malassezia. In: Griffin, C.E, Kwochka, K.W., MacDonald, J.M. eds. Current Veterinary Dermatology. The Science and Art of Therapy. St Louis: Mosby Year Book Inc., 1992: 44-9.
44. Mason, K.V. Malassezia Dermatitis and Otitis. In: Kirk, R.W., Bonagura, J.D., eds, Current Veterinary-Therapy XI. Philadelphia: W.B. Saunders & Co., 1992: 544-6.
45. Roberts, S.O.B. Pityrosporum orbiculare: incidence and distribution on clinically normal skin. British Journal of Dermatology 1969; 81: 264-9.
46. Hay, R.J. Fungi and fungal infections of the skin. In: Noble W.C., ed. The Skin Microflora and Microbial Skin Disease. Cambridge: Cambridge University Press, 1993: 232-63.
47. Nutting, W.B. Hair follicle mites (Demodex spp.) of medical and veterinary concern. The Cornell Veterinarian 1976; 66: 214-31.
48. Muller, G.H., Kirk, R.W., Scott, D.W. Small Animal Dermatology, 4th edn. Philadelphia: W.B. Saunders Co., 1989: 376-95.
49. Nutting, W.B., Desch, C. Demodex canis Redescription and re-evaluation. The Cornell Veterinarian 1978; 68: 139.
50. Sako, S. Studies on the canine demodicosis -IV. Experimental infection of Demodex folliculorum var canis to dogs. Transcripts of the Tottori Society of Agricultural Science 1964; 17: 45.
51. Greeve, J.H., Gaafar, S.M. Natural transmission of Demodex canis in dogs. Journal of American Veterinary Medical Association 1966; 148: 1043-5.
52. Sheahan, B.J., Gaafar, S.M. Experimental production of the lesions of canine demodecosis. Journal of the American Veterinary Medical Association 1970; 156: 1241-3.
53. Scarff, D.H. Morphological differences in Demodex spp. Proceedings of the Fifth Annual Congress of the European Society of Veterinary Dermatology, London; 1988.
54. Chen, C. A short-tailed demodectic mite and Demodex canis infestation in a chihuahua dog. Veterinary Dermatology 1995; 6: 227-9.
55. Montes, L.F., Wilborn, W.H. Anatomical location of normal skin flora. Archives of Dermatology 1970; 101: 145-59.
56. Lloyd, D.H., Dick, W.D.B., Jenkinson, D.M. Location of the microflora in the skin of cattle. British Veterinary Journal 1979; 135: 518-26.
57. Williamson, P., Kligman, A.M. A new method for the quantitative investigation of cutaneous bacteria. Journal of Investigative Dermatology 1965; 45: 498-503.
58. Noble, W.C., Somerville, S.A. Microbiology of Human Skin. London: W.B. Saunders.
59. Mason, I.S. Hypersensitivity and the multiplication of staphylococci on canine skin. PhD thesis. London: University of London, 1990.
60. Noble, W.C. Skin as a microhabitat. Postgraduate Medical Journal 1975; 51: 151-5.
61. Jenkinson, D.M. Topography, climate and chemical nature of the mammalian skin surface. In: Jenkinson, D.M., Roberts, R.J., eds. Proceedings of the Royal Society of Edinburgh 1980; 79B: 3-22.
62. Noble, W.C. Microbiology of Human Skin, 2nd edn. London: W.B. Saunders, 1981.
63. Lloyd, D.H. The effect of climate on the microbial ecology of the skin of cattle and sheep. PhD thesis. Glasgow: University of Glasgow, 1978.
64. Pillsbury, D.M., Rebell, G. The bacterial flora of the skin. Factors influencing the growth of resident and transient organisms. Journal of Investigative Dermatology 1952; 18: 173-86.
65. Taplin, D., Zaias, N., Rebell, G. Environmental influences on the microbiology of the skin. Archives of Environmental Health 1965; 11: 546-50.
66. Taplin, D., Lansdell, L., Allen, A.M., Rodriguez, R., Cortes, A. Prevalence of streptococcal pyoderma in relation to climate and hygiene. Lancet 1973; i: 501-3.
67. Bibel, D.J., LeBrun, J.R. Changes in cutaneous flora after wet occlusion. Canadian Journal of Microbiology 1975; 21: 496-500.
68. Duncan, W.C., McBride, M.E., Knox, J.M. Bacterial flora. The role of environmental factors. Journal of Investigative Dermatology 1969; 52: 479-84.
69. McBride, M.E., Duncan, W.C., Knox, J.M. The environment and the microbial ecology of human skin. Applied & Environmental Microbiology 1977; 33: 603-8.
70. Murphy, C.T. An in vitro study of the factors affecting the growth of skin bacteria. PhD thesis. London: University of London, 1973.
71. Jenkinson, D.M., Mabon, R.M., Manson, W. Sweat proteins. British Journal of Dermatology 1974; 90: 175-81.
72. Jenkinson, D.M., Lloyd, D.H., Mabon, R.M. The antigenic composition and source of soluble proteins on the surface of the skin of sheep. Journal of Comparative Pathology 1979; 89: 43-50.
73. Page, C.O., Remington, J.S. Immunologic studies in human sweat. Journal of Laboratory & Clinical Medicine 1967; 69: 634-50.
74. Lloyd, D.H., Mabon, R.M., Jenkinson, D.M. The antigenic constituents of cattle skin washings. Journal of Comparative Pathology 1977; 87: 75-82.
75. Garthwaite, G. Lloyd, D.H., Thomsett, L.R. The location of immunoglobulins and complement (C3) at the surface and within the skin of dogs. Journal of Comparative Pathology 1983; 93: 185-93.
76. Tomasi, T.B., Tan, E.M., Soloman, A., Prendergast, R.A. Characteristics of an immune system common to certain external secretions. Journal of Experimental Medicine 1965; 121: 101-24.
77. Lloyd, D.H., Jenkinson, D.M. Serum and skin surface antibody responses to intradermal vaccination of cattle with Dermatophilus congolensis. British Veterinary Journal 1981; 137: 601-7.
78. Lloyd, D.H., Jenkinson, D.M., Miller, P.N., Sykes, T.J. Sequential production of specific antibodies in serum and at the skin surface of cattle following intradermal vaccination with Dermatophihis congolensis. Veterinary Immunology & Imnnmopathology 1987; 16: 251-7.
79. Gebhart, W., Metze, D. Secretory immunoglobulins. In: Bos, J.D., ed. Skin Immune System (SIS). Boca Raton, Florida: CRC Press, 1989: 198-205.
80. Blank, H., Sagami, S., Boyd, C., Roth, F.J. The pathogenesis of superficial fungous infections in cultured human skin. Archives of Dermatology 1959; 79: 524-535.
81. King, R.D., Khan, H.A., Foye, J.C., Greenberg, J.H., Jones, H.E. Transferrin, iron and dermatophytes. I. Serum dermatophyte inhibitory component definitively identified as unsaturated transferrin. Journal of Laboratory & Clinical Medicine 1975; 86: 204-12.
82. Marcelis, J.H. Interaction between bacteria and iron binding proteins. Veterinary Research Communications 1980; 4: 151-64.
83. Emmett, M., Kloos, W.E. Amino acid requirements of staphylococci isolated from human skin. Canadian Journal of Microbiology 1975; 21: 729-33.
84. Onken, H.D., Moyer, C.A. The water barrier in human epidermis. Archives of Dermatology 1963; 87: 584-90.
85. Roberts, D.S. Barriers to Dermatophihis dermatonomus infection on the skin of sheep. Australian Journal of Agricultural Research 1963; 14: 492-508.
86. Rothman, S., Smiljanic, A., Shapiro, A.L., Weitkamp, A.W. The spontaneous cure of tinea capitis in puberty, Journal of Investigative Dermatology 1947; 8: 81-98.
87. Kligman, A.M., Ginsberg, D. Immunity of the adult scalp to infection with Microsporum audouini. Journal of Investigative Dermatology 1950; 14: 345-58.
88. Nieman, C. Influence of trace amounts of fatty acids on the growth of micro-organisms. Bacteriology Reviews 1954; 18: 147-63.
89. Adams, E.W., Rickard, C.G. The antistreptococcic activity of bovine teat canal keratin. American Journal of Veterinary Research 1963; 24: 122-35.
90. Ricketts, C.R., Squire, J.R., Topley, E. Human skin lipids with particular reference to the self-sterilising power of the skin. Clinical Science 1951; 10: 89-111.
91. Aly, R., Maibach, H.I., Shinefield, H.R., Strauss, W.G. Survival of pathogenic micro-organisms on human skin. Journal of Investigative Dermatology 1972; 58: 205-10.
92. Fraser, B. Pityrosporum pachydermatis (Weldman) of canine origin. Transactions of the British Mycological Society 1961; 44: 441-8.
93. Yang, L.P., Yi, Y.Y. A Canine model infection with Demodex folliculorum. Journal of Parasitology and Parasitic Diseases China 1988; 6: 138-42.
94. Ayers, S. Jr. Demodectic eruptions (Demodicosis) in the human. Archives of Dermatology 1961; 83: 816.
95. English, F.P., Nutting, W.B., Cohb, D. Eyelid mite nests. Australian Journal of Ophthalmology 1982; 10: 187-9.
96. Spickett, S.G. Studies on Demodex folliculorum Simon (1842) 1. Life History Parasitology 1961; 51: 181-92.
97. Jenkinson, D.M., Mabon, R.M. The effect of temperature and humidity on the skin surface pH and the ionic composition of skin secretions in Ayrshire cattle. British Veterinary Journal 1973; 129: 282-95.
98. Draize, J.H. The determination of the pH of the skin of man and common laboratory animals. Journal of Investigative Dermatology 1942; 5: 77-85.
99. Roy, W.E. Role of the sweat glands in eczema of dogs. A preliminary report. Journal of the American Veterinary Medical Association 1954; 124: 51-4.
100. Grono, L.R. Studies of the microclimate of the external auditory canal in the dog. Relative humidity within the external auditory meatus. Research in Veterinary Science 1970; 11: 316-9.
101. Grono, L.R., Frost, A.J. Otitis externa in the dog. The microbiology of the normal and affected ear canal. Australian Veterinary Journal 1969; 45: 420-2.
102. Jenkinson, D.M., Mabon, R.M. The corticosteroid content of cattle skin washings. Research in Veterinary Science 1975; 19: 94-5.
103. Halbert, S.P., Swick, L., Sonn, C. Characteristics of antibiotic producing strains of the ocular bacterial flora. Journal of Immunology 1953; 70: 400-10.
104. Reeves, P. The bacteriocines. Bacteriological Reviews 1965; 29: 24-45.
105. Selwyn, S., Ellis, H. Skin bacteria and skin disinfection reconsidered. British Medical Journal 1972; 1: 136-40.
106. Selwyn, S. Natural antibiosis among skin bacteria as a primary defence against infection. British Journal of Dermatology 1975; 93: 487-93.
107. Allaker, R.P., Lloyd, D.H., Noble, W.C. Studies on antagonism between porcine bacteria. Journal of Applied Biology 1989; 66: 507-14.
108. Dajani, A.S., Wannamaker, L.W. Experimental infection of the skin in the hamster simulating human impetigo. III. Interaction between staphylococci and group A streptococci. Journal of Experimental Medicine 1971; 134: 588-99.
109. Noble, W.C., Willie, J.A. Interactions between antibiotic-producing bacteria and non-producing staphylococci in skin surface and sub-surface models. British Journal of Experimental Pathology 1980; 61: 339-43.
110. Allaker, R.P., Lloyd, D.H., Lamport, A.I. Interaction of Staphylococcus hyicus and an inhibitor producing strain of Staphylococcus chromogenes on the skin of gnotobiotic piglets. Veterinary Dermatology 1990; 2: 93-5.
111. Gmeiner, F. Demodex folliculorum des menschen und der Tiere. Archives of Dermatology and Syphilology 1908; 92: 25.
112. English, F.P., Iwamoto, T., Darrell, R.W., DeVoe, A.G. The vector potential of Demodex folliculorum. Archives of Ophthalmology 1970; 84: 83-5.
113. Norm, M.S. Demodex folliculorum: incidence and possible pathogenetic role in human eyelid. Acta Ophthalmologica Supplementum 1970; 108: 166-177.
114. Norm, M.S. The follicle mite (Demodex folliculorum). Eye Ear Nose Throat (Mon) 1972; 51: 187-191.
115. Barta, O., Waltman, C., Oyekan, P.P., McGrath, R.K., Hribernik, T.N. Lymphocyte transformation suppression caused by pyoderma failure to demonstrate it in uncomplicated demodectic mange. Compendium on Immunology and Microbial Infectious Disease. 1983; 6: 9-17.
116. Barriga, O., Al-Khalidi, H.W., Martin, S., Wyman, M. Evidence of immunosupression by Demodex canis. Veterinary Immunology and Immunotherapy 1992; 32: 37-46.
117. Mason, K.V. Seborrhoeic dermatitis - the aetiology rediscovered. Proceedings of the British Veterinary Dermatology Study Group: Veterinary Dermatology Newsletter 1992; 14: 6-12.
118. Weary, P.E. Pityrosporum ovale. Observations on some aspects of host-parasite inter-relationship. Archives of Dermatology 1968; 98: 408-23.
119. Polonelli, L., Morace, G. Re-evaluation of the yeast killer phenomenon. Journal of Clinical Microbiology 1986; 24: 866-9.
120. Willett, H.P. Staphylococcus. In: Joklik, W.K., Willett, H.P., Amos, D.B., eds. Zinsser Microbiology, 17th edn. New York: Appleton-Century Crofts, 1983: 532-53.
121. Latimer, K.S., Prasse, K.W., Dawe, D.C. A transient deficit in neutrophilic chemotaxis in a dog with recurrent staphylococcal pyoderma. Veterinary Pathology 1982; 19: 223-9.
122. Rosenberg, E.W., Belew, P., Bale, G. Effect of topical application of heavy suspension of killed Malassezia ovalis on rabbit skin. Mycopathologica 1980; 72: 147-54.
123. Marples, R.R., Downing, D.T., Kligman, A.M. Influence of Pityrosporum species in the generation of free fatty acids in human surface lipids. Journal of Investigative Dermatology 1972; 58: 155-159.
124. Dzairski, R. Effects of staphylococcal cell wall products on immunity. In: Friedman, H. et al., eds. Imnnmomodulation by Bacteria and their Products. New York, Plenum, 1981: 94-133.
125. Dzairski, R. Antibody responses to Staphylococcus aureus cell wall antigens. Clinical Immunology Newsletter 1985; 6: 58-62.
126. Pfanneberg, T., Blobel, H., Schaeg, W. Cytotoxic effects of a leukocidin from Staphylococcus aureus. Zentralblatt fur Bakteriologie Mikrobiologie und Hygiene 1 Abteilung Originale A 1975; 233: 147-52.
127. Johnson, A.D., Spero, L., Cades, J.S., Decicco, B.T. Purification and characterisation of different types of exfoliative toxin from Staphylococcus aureus. Infection & Immunity 1979; 24: 679-84.
128. Hajek, V. Staphylococcus intermedius, a new species isolated from animals. International Journal of Systemic Bacteriology 1976; 26: 401-8.
129. Allaker, R.P., Lamport, A.I., Lloyd, D.H., Noble, W.C. Production of 'virulence factors' by Staphylococcus intermedius isolates from cases of canine pyoderma and healthy carriers. Microbial Ecology in Health & Disease 1991; 4: 169-73.
130. Ishak, M.A., Groschel, D.H.M., Mandell, G.L., Wenzel, R.P. Association of slime with pathogenicity of coagulase-negative staphylococci causing nosocomial septicaemia. Journal of Clinical Microbiology 1985; 22: 1025-9.
131. Keane, K.A., Taylor, D.J. Slime-producing Staphylococcus species in canine pyoderma. Veterinary Record 1992; 130: 75.
132. Cole, G.W., Silverberg, N.L. The adherence of Staphylococcus aureus to human corneocytes. Archives of Dermatology 1986; 122: 166-9.
133. McEwan, N.A. Canine staphylococcal pyoderma Proceedings of the British Veterinary Dermatology Study Group: Veterinary Dermatology Newsletter 1991; 13: 27-34.
134. Peters, G. Gray, E.D., Johnson, G.M. Immunomodulatory properties of extracellular slime substance. In: Bisno, A.L, Waldvogel, D.C., eds. Infections Associated with Indwelling Medical Devices. Washington DC, American Society of Microbiology, 1989: 61-74.
135. Wilkinson, B.J., Kim, Y., Pereson, P.K., Quie, P.G., Michael, A.F. Activation of complement by cell surface components of Staphylococcus aureus. Infection & Immunity 1978; 20: 388-92.
136. Sjoquist, J. Structure and immunology of protein A. In: Jeljaszewicz, J., Hryniewicz, W., eds. Staphylococci and Staphylococcal Infections. Basel: S. Karger, 1973: 83-92.
137. Cox, H.V., Schmeer, N., Newman, S.S. Protein A in Staphylococcus intermedius isolates from dogs and cats. American Journal of Veterinary Research 1986; 47: 1881-4.
138. Fehrer, S.L., Boyle, M.D.P., Halliwell, R.E.W. Identification of Protein A from Staphylococcus aureus isolated from canine skin. American Journal of Veterinary Science 1988; 49: 697-701.
139. Allaker, R.P., Lloyd, D.H. Extracellular pathogenicity factors of Staphylococcus intermedius In: Mollby, R., Flock, J.I., eds. Proceedings of the 7th International Symposium on Staphylococci and Staphylococcal Infections. Zentralblatt fur Bakteriologie (Suppl), Stockholm 1993; 26 (no page numbers).
140. Mason, I.S., Lloyd, D.H. The role of allergy in the development of canine pyoderma. Journal of Small Animal Practice 1989; 30: 216-8.
141. Mason, I.S., Lloyd, D.H. Factors influencing the penetration of bacterial antigens through canine skin. In: von Tscharner, C., Halliwell, R.E.W., eds. Advances in Veterinary Dermatology, Volume 1. London: Bailliere Tindall, 1990: 370-4.
142. Mudd, S. Resistance against Staphylococcus aureus. Journal of the American Medical Association. 1971; 218: 1671-3.
143. Bolen, J.B., Tribble, J.L. Delayed hypersensitivity reactions to Staphylococcus aureus in mice: in vivo response to isolated staphylococcal antigen. Immunology 1979; 38: 809-17.
144. Mayenburg, J.V., Heymer, B., Dungeman, H. et al. Studies on bacterial hypersensitivity in man. Allergy 1982; 37: 249-58.
145. Mason, I.S., Lloyd, D.H. The macroscopic and microscopic effects of intradermal injection of crude and purified staphylococcal extracts on canine skin Veterinary Dermatology 1995; 6: 197-203.
146. Faergemann, J., Aly, R., Maibach, H.I. Adherence of Pityrosporum orbiculare to human stratum corneum cells. Archives of Dermatology and Research. 1983; 275: 246-50.
147. Bond, R., Lloyd, D.H. Factors affecting the adherence of Malassezia pachydermatis to canine corneocytes in vitro. Veterinary Dermatology 1996; 7: 49-55.
148. Nazzaro-Porro, M., Passi, S., Caprilli, F. et al. Induction of hyphae in cultures of Pityrosporum by cholesterol and cholesterol esters. Journal of Investigative Dermatology 1977; 69: 531-4.
149. Wilde, P.E., Stewart, P.S. A Study of the fatty acid metabolism of the yeast Pityrosporum ovale. Biochemical Journal 1968; 108: 225-31.
150. Noble, W., Midgley, G. Scalp carriage of Pityrosporum species: the effect of physiological maturity, sex and race. Sabouraudia 1978; 16: 229-32.
151. Pierard, J., Dockx, P. The ultrastructure of Tinea versicolor and Malassezia furfur. International Journal of Dermatology 1972; 11: 116-24.
152. Borgers, M., Cauwenbergh, G., Vand De Ven, M., Hernanz, A., Degreef, H. Pitriasis versicolor and Pityrosporum ovale. Morphogenetic and ultrastructural considerations. International Journal of Dermatology. 1987; 26: 586-9.
153. Wikler, J., Janssen, N., Bruynzeel, D., Nieboer, C. The effect of uv-light on Pityrosporum yeasts: Ultrastructural changes and inhibition of growth. Acta Dermatovenereologica (Stockholm) 1990; 70: 69-71.
154. Rosenberg, W.E., Belew, P., Jennings, B. Activation of the alternative pathway of complement by Malassezia ovalis (Pityrosporum ovale). Mycopathologica 1980; 70: 187-91.
155. Sohnle, P.G., Collins-Lecl, C. Activation of complement by Pityrosporum orbiculare. Journal of Investigative Dermatology. 1983; 80: 93-7.
156. Nutting, W.B. Pathogenesis associated with hair follicle mites (Acari: demodeciae). Acarologia 1975; 17: 493-507.
157. Nutting, W.B., Bioecology of Prostigmate mites (Prostigmata). In: W.B. Nutting, ed. Mammalian Diseases and Arachnids. Boca Raton, Florida: CRC Press 1984; 1: 144-167.
158. Nutting, W.B. Demodicidae status and prognostics. Acarologia 1964; 6: 441-454.
159. French, F., Raun, E.S. & Baker, D.L. Transmission of Demodex canis (Leydig) to pups. Iowa State Journal of Science 1984; 38: 291-8.
160. Kligman, A.M. The biology of the stratum corneum. In: W. Montagna, W.C. Lobitz., eds. The Epidermis. New York: Academic Press, 1963: 387-433.
161. Scheuplein, R.J., Blank, I.H. Permeability of the skin. Physiological Reviews 1971; 51: 702-47.
162. Dugard, P.H., Walker, M., Mawdsley, S.J. Scott, R.C. Absorption of some glycol ethers through human skin in vitro. Environmental Health Perspectives 1984; 57: 193-7.
163. Lai a Fat, R.F., Van Furth, R. The role of skin and adjacent mucous membranes in host defense. Journal of Cutaneous Pathology 1974; 1: 61-70.
164. Lloyd, D.H., Garthwaite, G. Epidermal structure and surface topography of canine skin. Research in Veterinary Science 1982; 33: 99-104.
165. Jenkinson, D.M., Lloyd, D.H. The topography of the skin surface of cattle and sheep. British Veterinary Journal 1979; 135: 376-79.
166. Roberts, D.S. Barriers to Dermatophilus dermatonomus infection on the skin of sheep. Australian Journal of Agricultural Research 1963; 14: 492-508.
167. Lloyd, D.H., Dick, W.D.B., Jenkinson, D.M. The effect of some surface sampling procedures on the stratum corneum of bovine skin. Research in Veterinary Science 1979; 26: 250-2.
168. Lloyd, D.H., Jenkinson, D.M. The effect of climate on experimental infections of bovine skin with Dermatophilus congolensis. British Veterinary Journal 1980; 136: 122-34.
169. Lloyd, D.H., Dick, W.D.B., Jenkinson, D.M. Structure of the epidermis in Ayrshire bullocks. Research in Veterinary Science 1979; 26: 172-9.
170. Lloyd, D.H., Amakiri, S.F., Jenkinson, D.M. Structure of the sheep epidermis. Research in Veterinary Science 1979; 26: 180-2.
171. Jenkinson, D.M., Lloyd, D.H., Mabon, R.M. Location of the source of soluble skin surface proteins of cattle by immunofluorescence. Research in Veterinary Science 1976; 21: 124-6.
172. Mason, I.S., Lloyd, D.H. Scanning electron microscopical studies of the living epidermis and stratum corneum in dogs. In: Ihrke, P.J., Mason, I.S., White, S.D., eds. Advances in Veterinary Dermatology, Vol. 1. 1993: 131-9.
173. Hashimoto, K. Intercellular spaces of the human epidermis as demonstrated with lanthanum. Journal of Investigative Dermatology 1971; 57: 17-31.
174. Elias, P.M., Friend, D.S. The permeability barrier in mammalian epidermis. Journal of Cell Biology 1975; 65: 180-91.
175. Squier, C.A., Hopps, R.M. A study of the permeability barrier in epidermis and oral epithelium using horse-radish peroxidase as a tracer in vitro. British Journal of Dermatology 1976; 95: 123-9.
176. Skerrow, C.J., Skerrow, D. Desmosomes and filaments in mammalian epidermis. In: Curtis, A.S., Pitts, J.R., eds. Cell Adhesion and Motility. Cambridge: University Press, 1980: 445-64.
177. Matoltsy, A.G. Comment on the defence system of the mammalian epidermis. In: Jenkinson, D.M., Roberts, R.J., eds. Proceedings of the Royal Society of Edinburgh. 1980: 79B: 23-4.
178. Sohnle, P.G., Kirkpatrick, C.H. Epidermal proliferation in the defense against experimental cutaneous candidiasis. Journal of Investigative Dermatology 1978; 70: 130-3.
179. Csato, M., Rosenbach, T., Grabbe, J., Czametzki, B. Epidermal scales: Are they a wastebasket of inflammatory mediators or active participants in epidermal inflammation. International Journal of Dermatology 1989; 28: 86-89.
180. Quadros, E. Furunculosis in dogs. Aetiology, pathogenesis and treatment. Acta veterinaria Scandinavica 1974; 52(Suppl.): 1-114.
181. Jenkinson, D.M., Nimmo, M.C., Jackson, D. et al. Comparative studies of the effect of thermal stimulation on the permeability of the luminal junctions of the sweat gland to lanthanum. Tissue and Cell 1983; 15: 573-81.
182. Jackson, D., McQueen, L., Jenkinson, D.M., Nimmo, M.C., Elder, H.Y., Montgomery, I. Passage of lanthanum through the intercellular spaces of the sebaceous gland. Research in Veterinary Science 1986; 40: 48-53.