Comparative study of the biotransformation of bepridil analogs in isolated liver cells from one rat. Relationships between structure and in vitro liver toxicity

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 21, Issue 4, 1996, Pages 315-325

  Damatte, E ^a   Galmier, M J ^a   Lartigue Mattei, C ^a   Pognat, J F ^b   Busch, N ^a   Chabard, J L ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b CERM Centre Europeen de Recherches Mauvernay   (France)

Author keywords

Bepridril analogs; In vitro metabolism; Liver toxicity

Indexed keywords

1 [3 METHOXY 2 (N BENZYL)ANILINE]PROPYLPYRROLIDINE FUMARATE; 4 [[2 (2 METHYLPROPOXY) 1 [[PHENYL(PHENYLMETHYL)AMINO]METHYL]ETHYL]AMINO]BUTANOIC ACID; BEPRIDIL; CALCIUM ANTAGONIST; DRUG METABOLITE; N (2 METHOXY)PHENYL N PHENYLMETHYL BETA (2 METHYL)PROPOXYMETHYL 1 PYRROLIDINEETHANAMINE FUMARATE; N (2,6 DIMETHYL)PHENYL N PHENYLMETHYL BETA (2 METHYL)PROPOXYMETHYL 1 PYRROLIDINEETHANAMINE FUMARATE; N (3 CHLORO)PHENYL N PHENYLMETHYL BETA (2 METHYL)PROPOXYMETHYL 1 PYRROLIDINEETHANAMINE FUMARATE; N (3 TRIFLUOROMETHYL)PHENYL N PHENYLMETHYL BETA (2 METHYL)PROPOXYMETHYL 1 PYRROLIDINEETHANAMINE; N (3,4 DICHLORO)PHENYL N PHENYLMETHYL BETA (2 METHYL)PROPOXYMETHYL 1 PYRROLIDINEETHANAMINE; N (3,5 DICHLORO)PHENYL N PHENYLMETHYL BETA (2 METHYL)PROPOXYMETHYL 1 PYRROLIDINEETHANAMINE; N (4 CHLORO)PHENYL N PHENYLMETHYL BETA (2 METHYL)PROPOXYMETHYL 1 PYRROLIDINEETHANAMINE; N (4 METHOXY)PHENYL N PHENYLMETHYL BETA (2 METHYL)PROPOXYMETHYL 1 PYRROLIDINEETHANAMINE FUMARATE; N (4 METHYL)PHENYL N PHENYLMETHYL BETA (2 METHYL)PROPOXYMETHYL 1 PYRROLIDINEETHANAMINE FUMARATE; N PHENYLMETHYL N PHENYL BETA (2 METHYL 2 HYDROXY)PROPOXYMETHYL 1 PYRROLIDINEETHANAMINE HYDRATE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG STRUCTURE; DRUG TRANSFORMATION; HYDROXYLATION; LIVER CELL; LIVER TOXICITY; MALE; MASS SPECTROMETRY; NONHUMAN; RAT;

EID: 0030513572     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03189733     Document Type: Article

References (14)

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