Somatostatin-positive neurons in the different parts of the brain in normal aging and alzheimer’s disease

NeuroSignals

Volumn 5, Issue 6, 1996, Pages 343-348

  Li, Wei Ping ^a   Lai, Helen W L ^b   Cheng, Suet Ying ^b   Yew, David T ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Alzheimer s disease; Apoptosis; Cortex; Somatostatin

Indexed keywords

SOMATOSTATIN;

AGED; AGING; ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN REGION; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NERVE CELL;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; BRAIN; CEREBRAL CORTEX; FLUORESCENT ANTIBODY TECHNIQUE; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; NEURONS; PYRAMIDAL CELLS; REFERENCE VALUES; SOMATOSTATIN; TISSUE DISTRIBUTION;

EID: 0030513160     PISSN: 1424862X     EISSN: 14248638     Source Type: Journal    
DOI: 10.1159/000109207     Document Type: Article

References (18)

1. Leake A, Perry EK, Perry RH, Ja-been S, Fairbaim AF, McKeith IG, Ferrier IN: Neocortical concentrations of neuropeptides in senile dementia of the Alzheimer and Lewy body type: Comparison with Parkinson’s disease and severity correlations. Biol Psychiatry 1991:29:357-364.
2. Mazurek MF, Beal MF: Cholecysto-kinin and somatostatin in Alzheimer’s disease postmortem cerebral cortex. Neurology 1991:41:716-719.
3. Beal MF: Somatostatin in neurodc-generative illnesses. Metabolism 1990;39:116-119.
4. Raff CR: Social controls on cell survival and cell death. Nature 1992; 356:397-400.
5. Brazeau P, Vale W, Burguo R, Ling W, Butcher M, Rivier J, Gurillemin R: Hypothalamic peptide that inhibits the secretion of immunoreactivc pituitary growth hormone. Science 1973:179:77-79.
6. Ong WY, Garey LJ: Distribution of GABA and neuropeptides in the human cerebral cortex. A light and electron microscopic study. Anat Embryol 1991;183:397-413.
7. Su JH, Anderson AJ, Cummings BJ, Cotman CW: Immunohistochemi-cal evidence for apoptosis in Alzheimer’s disease. Neuroreport 1994; 5:2529-2533.
8. Smale G, Nichols NR, Brady DR, Finch CE, Horton WE Jr: Evidence for apoptotic cell death in Alzheimer’s disease. Exp Neurol 1995; 133: 225-230.
9. Ang LC, Shul DD: Peptidergic neurons of subcortical white matter in aging and Alzheimer’s brain. Brain Res 1995;674:329-335.
10. Dournaud P, Cervera-Pierot P, Hirsch E, Javoy-Agid F, Kordon C, Agid Y, Epelbaum J: Somatostatin messenger RNA-containing neurons in Alzheimer’s disease: An in situ hybridization study in hippocampus, parahippocampal cortex and frontal cortex. Neuroscience 1994; 61:755-764.
11. Chan-Palay V: Somatostatin immu-noreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: Coexistence with neuropeptide Y neurons, and effects in Alzheimer-type dementia. J Comp Neurol 1987;260:201-223.
12. Dawbam D, Rossor MN, Mountjoy CQ, Roth M, Emson PC: Decreased somatostatin immunorcactivity but not neuropeptide Y immunoreactiv-ity in cerebral cortex in senile dementia of Alzheimer type. Neurosci Lett 1986;70:154-159.
13. Gaspar P, Duyckaerts C, Febvret A, Benoit R, Beck B, Berger B: Subpopulations of somatostatin 28-immu-noreactive neurons display different vulnerability in senile dementia of the Alzheimer type. Brain Res 1989; 490:1-13.
14. Roberts GW, Crow TJ, Polak JM: Location of neuronal tangles in somatostatin neurons in Alzheimer’s disease. Nature 1985;314:7-13.
15. Sorrison JH, Rogers J, Scherr S, Benoit R, Bloom FE: Somatostatin im-munoreactivity in neurotic plaques of Alzheimer patients. Nature 1985; 314:90-92.
16. Ichai C, Chevallier N, Delaere P, Doumaud P, Epelbaum J, Hauw JJ, Vincent JP, Chccler F: Influence of region-specific alterations of neuropeptidase content on the catabolic rates of neuropeptides in Alzheimer’s dicasc. J Ncurochem 1994;62: 645-655.
17. Krantic S, Robitaille Y, Quirion R: Deficits in the somatostatin SSI receptor sub-type in frontal and temporal cortices in Alzheimer’s diease. Brain Res 1992;573:299-304.
18. Bergstrom L, Garlind A, Nilsson L, Alafuzoff I, Fowler CJ, Winblad B, Cowbum RF: Regional distribution of somatostatin receptor binding and modulation of adenylyl cyclase activity in Alzheimer’s disease brain. J Neurol Sei 1991; 105:225-233.