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Volumn 4, Issue 5, 1996, Pages 200-210

PEG-hemoglobin: Effects on tumor oxygenation and radiosensitization

Author keywords

blood substitute radiosensitization; oxygen delivery; PEG hemoglobin; tumor hypoxia

Indexed keywords

HEMOGLOBIN; MACROGOL;

EID: 0030513076     PISSN: 10657541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6823(1996)4:5<200::AID-ROI2>3.0.CO;2-1     Document Type: Article
Times cited : (10)

References (73)
  • 1
    • 0002240218 scopus 로고
    • Angiogenesis and blood flow
    • Teicher BA (ed): New York: Marcel Dekker
    • Dewhirst MW: Angiogenesis and blood flow. In Teicher BA (ed): Drug Resistance in Oncology. New York: Marcel Dekker, pp 3-24, 1993.
    • (1993) Drug Resistance in Oncology , pp. 3-24
    • Dewhirst, M.W.1
  • 3
    • 0023902264 scopus 로고
    • Therapeutic attack of hypoxic cells of solid tumors: Presidential address
    • Sartorelli AC: Therapeutic attack of hypoxic cells of solid tumors: Presidential address. Cancer Res 48:775-778, 1988.
    • (1988) Cancer Res , vol.48 , pp. 775-778
    • Sartorelli, A.C.1
  • 4
    • 0019349297 scopus 로고
    • Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells
    • Teicher BA, Lazo JS, Sartorelli AC: Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells. Cancer Res 41:73-81, 1981.
    • (1981) Cancer Res , vol.41 , pp. 73-81
    • Teicher, B.A.1    Lazo, J.S.2    Sartorelli, A.C.3
  • 5
    • 0002972851 scopus 로고
    • Oxygenation of solid tumors
    • Teicher BA (ed): New York: Marcel Dekker
    • Vaupel P: Oxygenation of solid tumors. In Teicher BA (ed): Drug Resistance in Oncology. New York: Marcel Dekker, pp 53-85, 1993.
    • (1993) Drug Resistance in Oncology , pp. 53-85
    • Vaupel, P.1
  • 6
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel P, Kallinowski F, Okunieff P: Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review. Cancer Res 49:6449-6465, 1989.
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 8
    • 0017247945 scopus 로고
    • In vivo utilization of oxygen and glucose by neoplastic tissue
    • Gullino PM: In vivo utilization of oxygen and glucose by neoplastic tissue. Adv Exp Med Biol 75:521-536, 1975.
    • (1975) Adv Exp Med Biol , vol.75 , pp. 521-536
    • Gullino, P.M.1
  • 10
    • 0023909330 scopus 로고
    • Determinants of tumor blood flow: A review
    • Jain RK: Determinants of tumor blood flow: A review. Cancer Res 48:2641-2658, 1988.
    • (1988) Cancer Res , vol.48 , pp. 2641-2658
    • Jain, R.K.1
  • 11
    • 0023688667 scopus 로고
    • Characterization of radiation resistant hypoxic cell subpopulations in KHT sarcomas. (ii) Cell sorting
    • Siemann DW, Keng PC: Characterization of radiation resistant hypoxic cell subpopulations in KHT sarcomas. (ii) Cell sorting. Br J Cancer 58:296-300, 1988.
    • (1988) Br J Cancer , vol.58 , pp. 296-300
    • Siemann, D.W.1    Keng, P.C.2
  • 13
    • 0023227393 scopus 로고
    • Blood flow, oxygen consumption and tissue oxygenation of human breast cancer xenografts in nude rats
    • Vaupel P, Fortmeyer HP, Runkel S, Kallinowski F: Blood flow, oxygen consumption and tissue oxygenation of human breast cancer xenografts in nude rats. Cancer Res 47:3496-3503, 1987.
    • (1987) Cancer Res , vol.47 , pp. 3496-3503
    • Vaupel, P.1    Fortmeyer, H.P.2    Runkel, S.3    Kallinowski, F.4
  • 14
    • 0019461848 scopus 로고
    • Heterogeneous oxygen partial pressure and pH distribution C3H mouse mammary adenocarcinoma
    • Vaupel P, Frinak S, Bicher HI: Heterogeneous oxygen partial pressure and pH distribution C3H mouse mammary adenocarcinoma. Cancer Res 41:2008-2013, 1981.
    • (1981) Cancer Res , vol.41 , pp. 2008-2013
    • Vaupel, P.1    Frinak, S.2    Bicher, H.I.3
  • 15
    • 0021971997 scopus 로고
    • Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro
    • Keyes SR, Rockwell S, Sartorelli AC: Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro. Cancer Res 45:3642-3645, 1985.
    • (1985) Cancer Res , vol.45 , pp. 3642-3645
    • Keyes, S.R.1    Rockwell, S.2    Sartorelli, A.C.3
  • 16
    • 0023205450 scopus 로고
    • Effects of various oxygenation conditions on the enhancement by Fluosol-DA of melphalan antitumor activity
    • Teicher BA, Crawford JM, Holden SA, Cathcart KNS: Effects of various oxygenation conditions on the enhancement by Fluosol-DA of melphalan antitumor activity. Cancer Res 47:5036-5041, 1987.
    • (1987) Cancer Res , vol.47 , pp. 5036-5041
    • Teicher, B.A.1    Crawford, J.M.2    Holden, S.A.3    Cathcart, K.N.S.4
  • 17
    • 0023092376 scopus 로고
    • Approaches to defining the mechanism of enhancement by Fluosol-DA 20% with carbogen of melphalan antitumor activity
    • Teicher BA, Holden SA, Jacobs JL: Approaches to defining the mechanism of enhancement by Fluosol-DA 20% with carbogen of melphalan antitumor activity. Cancer Res 47:513-518, 1987.
    • (1987) Cancer Res , vol.47 , pp. 513-518
    • Teicher, B.A.1    Holden, S.A.2    Jacobs, J.L.3
  • 18
    • 0022401539 scopus 로고
    • Effect of oxygen on the cytotoxicity and antitumor activity of etoposide
    • Teicher BA, Holden SA, Rose CM: Effect of oxygen on the cytotoxicity and antitumor activity of etoposide. J Natl Cancer Inst 75:1129-1133, 1985.
    • (1985) J Natl Cancer Inst , vol.75 , pp. 1129-1133
    • Teicher, B.A.1    Holden, S.A.2    Rose, C.M.3
  • 19
    • 0023775083 scopus 로고
    • Effect of various oxygenation conditions and Fluosol-DA on cancer chemotherapeutic agents
    • Teicher BA, McIntosh-Lowe NL, Rose CM: Effect of various oxygenation conditions and Fluosol-DA on cancer chemotherapeutic agents. Biomater Artif Cells Immobil Biotech 16:533-546, 1988.
    • (1988) Biomater Artif Cells Immobil Biotech , vol.16 , pp. 533-546
    • Teicher, B.A.1    McIntosh-Lowe, N.L.2    Rose, C.M.3
  • 20
    • 0024459584 scopus 로고
    • Evidence for enzymatic activation and oxygen involvement in cytotoxicity and antitumor activity of N,N′,N″-triethylenethiphosphoramide
    • Teicher BA, Waxman DJ, Holden SA, Wang Y, Clarke L, Alvarez Sotomayor E, Jones SM, Frei III E; Evidence for enzymatic activation and oxygen involvement in cytotoxicity and antitumor activity of N,N′,N″-triethylenethiphosphoramide. Cancer Res 49:4996-5001, 1989.
    • (1989) Cancer Res , vol.49 , pp. 4996-5001
    • Teicher, B.A.1    Waxman, D.J.2    Holden, S.A.3    Wang, Y.4    Clarke, L.5    Alvarez Sotomayor, E.6    Jones, S.M.7    Frei III, E.8
  • 21
    • 0002715879 scopus 로고
    • On the effect of anemia on the reactions of skin and of tumors to radium exposure
    • Mottram JC, Eidinow A: On the effect of anemia on the reactions of skin and of tumors to radium exposure. Br J Surg 19:481-487, 1932.
    • (1932) Br J Surg , vol.19 , pp. 481-487
    • Mottram, J.C.1    Eidinow, A.2
  • 22
    • 0018597250 scopus 로고
    • Optimal hematocrit for canine skeletal muscle during rhythmic isotomic exercise
    • Gaehtgens P, Kreutz P, Albrecht KH: Optimal hematocrit for canine skeletal muscle during rhythmic isotomic exercise. Eur J Appl Physiol 41:27-39, 1979.
    • (1979) Eur J Appl Physiol , vol.41 , pp. 27-39
    • Gaehtgens, P.1    Kreutz, P.2    Albrecht, K.H.3
  • 23
    • 0016356833 scopus 로고
    • Vascular resistance and oxygen transport as functions of hematocrit
    • Halmagyi DFJ, Goodman AH: Vascular resistance and oxygen transport as functions of hematocrit. Resuscitation 3:165-170, 1974.
    • (1974) Resuscitation , vol.3 , pp. 165-170
    • Halmagyi, D.F.J.1    Goodman, A.H.2
  • 25
    • 0021674166 scopus 로고
    • The effect of hematocrit on tumour sensitivity to X-rays
    • Hirst DG, Hazlehurst JL, Brown JM: The effect of hematocrit on tumour sensitivity to X-rays. Int J Radiat Biol 46:345-354, 1984.
    • (1984) Int J Radiat Biol , vol.46 , pp. 345-354
    • Hirst, D.G.1    Hazlehurst, J.L.2    Brown, J.M.3
  • 27
    • 0015069234 scopus 로고
    • Effect of induced host anemia on the viability and radiosensitivity of murine malignant cells in vivo
    • Hewitt HB, Blake E: Effect of induced host anemia on the viability and radiosensitivity of murine malignant cells in vivo. Br J Cancer 25:323-336, 1971.
    • (1971) Br J Cancer , vol.25 , pp. 323-336
    • Hewitt, H.B.1    Blake, E.2
  • 29
    • 0025329088 scopus 로고
    • Oxygenation of human tumors
    • Vaupel P: oxygenation of human tumors. Strahlenther Onkol 166:377-386, 1990.
    • (1990) Strahlenther Onkol , vol.166 , pp. 377-386
    • Vaupel, P.1
  • 30
    • 0023775078 scopus 로고
    • Attempts to find a method to prepare artificial hemoglobin corpuscles
    • Chang TMS: Attempts to find a method to prepare artificial hemoglobin corpuscles. Biomater Artif Cells Artif Organs 16:1-11, 1988.
    • (1988) Biomater Artif Cells Artif Organs , vol.16 , pp. 1-11
    • Chang, T.M.S.1
  • 31
    • 0026709522 scopus 로고
    • Blood substitutes based on modified hemoglobin prepared by encapsulation or crosslinking: An overview
    • Chang TMS: Blood substitutes based on modified hemoglobin prepared by encapsulation or crosslinking: An overview. Biomater Artif Cells Immobil Biotech 20(2-4):159-179, 1992.
    • (1992) Biomater Artif Cells Immobil Biotech , vol.20 , Issue.2-4 , pp. 159-179
    • Chang, T.M.S.1
  • 32
    • 0023804160 scopus 로고
    • Red blood cell substitutes: Microencapsulated hemoglobin and cross-lined hemoglobin including pyridoxylated polyhemoglobin and conjugated hemoglobin
    • Chang TMS: Red blood cell substitutes: Microencapsulated hemoglobin and cross-lined hemoglobin including pyridoxylated polyhemoglobin and conjugated hemoglobin. Biomater Artif Cells Immobil Biotech 16:11-29, 1988.
    • (1988) Biomater Artif Cells Immobil Biotech , vol.16 , pp. 11-29
    • Chang, T.M.S.1
  • 33
    • 0019426022 scopus 로고
    • Interactions of organic phosphates with bovine hemoglobin: I. Oxylabile and phosphate-labile proton binding
    • Breepel PM, Kreuzer F, Hazevoet M: Interactions of organic phosphates with bovine hemoglobin: I. Oxylabile and phosphate-labile proton binding. Pflugers Arch 389:219-225, 1981.
    • (1981) Pflugers Arch , vol.389 , pp. 219-225
    • Breepel, P.M.1    Kreuzer, F.2    Hazevoet, M.3
  • 34
    • 0015210116 scopus 로고
    • Differences in the interaction of 2,3-diphosphoglycerate with certain mammalian hemoglobins
    • Bunn HF: Differences in the interaction of 2,3-diphosphoglycerate with certain mammalian hemoglobins. Science 172:1049-1050, 1971.
    • (1971) Science , vol.172 , pp. 1049-1050
    • Bunn, H.F.1
  • 35
    • 0015993283 scopus 로고
    • Immunologic properties of stroma vs. stroma-free hemoglobin solution
    • Cochen A, Das Gupta TK, DeWoskin R, Moss GS: Immunologic properties of stroma vs. stroma-free hemoglobin solution. J Surg Oncol 4:19-28, 1974.
    • (1974) J Surg Oncol , vol.4 , pp. 19-28
    • Cochen, A.1    Das Gupta, T.K.2    DeWoskin, R.3    Moss, G.S.4
  • 36
    • 0019352051 scopus 로고
    • Oxygen-binding and immunological properties of complexes between dextran and animal hemoglobins
    • Cunnington PG, Jenkins SN, Tam SC, Wong JT: Oxygen-binding and immunological properties of complexes between dextran and animal hemoglobins. Biochem J 193:261-266, 1981.
    • (1981) Biochem J , vol.193 , pp. 261-266
    • Cunnington, P.G.1    Jenkins, S.N.2    Tam, S.C.3    Wong, J.T.4
  • 37
    • 0017622522 scopus 로고
    • Hemoglobin-O2 affinity regulation; DPF, monovalent ions, and hemoglobin concentration
    • Laver MD, Jackson E, Scherperel M, Tung C, Radford EP: Hemoglobin-O2 affinity regulation; DPF, monovalent ions, and hemoglobin concentration. J Appl Physiol 43:632-642, 1977.
    • (1977) J Appl Physiol , vol.43 , pp. 632-642
    • Laver, M.D.1    Jackson, E.2    Scherperel, M.3    Tung, C.4    Radford, E.P.5
  • 38
    • 0001502640 scopus 로고
    • Distribution of acid-soluble phosphorous in the blood cells of various vertebrates
    • Rapoport S, Guest GM: Distribution of acid-soluble phosphorous in the blood cells of various vertebrates. J Biol Chem 138:269-280, 1941.
    • (1941) J Biol Chem , vol.138 , pp. 269-280
    • Rapoport, S.1    Guest, G.M.2
  • 39
    • 0025347279 scopus 로고
    • Unusual specificity of the androgen receptor in the human prostate tumor cell line LNCaP: High affinity for progestagenic and estrogenic steroids
    • Veldscholte J, Voorhorst-Ogink M, Bolt-deVries J, vanRooij H, Trapman J, Mulder E: Unusual specificity of the androgen receptor in the human prostate tumor cell line LNCaP: High affinity for progestagenic and estrogenic steroids. Biochem Biophys Acta 1052:187-194, 1990.
    • (1990) Biochem Biophys Acta , vol.1052 , pp. 187-194
    • Veldscholte, J.1    Voorhorst-Ogink, M.2    Bolt-deVries, J.3    Vanrooij, H.4    Trapman, J.5    Mulder, E.6
  • 40
    • 0022550389 scopus 로고
    • Toxicologic studies of a conjugate of asparaginase and polyethylene glycol in mice, rats and dogs
    • Viau A, Abuchowski A, McCoy J, Kazo G, Davis F: Toxicologic studies of a conjugate of asparaginase and polyethylene glycol in mice, rats and dogs. Am J Vet Res 47(6):1398-401, 1986.
    • (1986) Am J Vet Res , vol.47 , Issue.6 , pp. 1398-1401
    • Viau, A.1    Abuchowski, A.2    McCoy, J.3    Kazo, G.4    Davis, F.5
  • 41
    • 0026124772 scopus 로고
    • The therapeutic value of poly(ethylene glycol)-modified proteins
    • Nucci ML, Shorr R, Abuchowski A: The therapeutic value of poly(ethylene glycol)-modified proteins. Adv Drug Deliv Rev 6:133-151, 1991.
    • (1991) Adv Drug Deliv Rev , vol.6 , pp. 133-151
    • Nucci, M.L.1    Shorr, R.2    Abuchowski, A.3
  • 42
    • 0025019752 scopus 로고
    • The clinical efficacy of polyethylene glycol-modified proteins
    • Fuertges F, Abuchowski A: The clinical efficacy of polyethylene glycol-modified proteins. J Controlled Release 11:139-148, 1990.
    • (1990) J Controlled Release , vol.11 , pp. 139-148
    • Fuertges, F.1    Abuchowski, A.2
  • 43
    • 0001139005 scopus 로고
    • Enzyme-polyethylene glycol adducts:modified enzymes with unique properties
    • Davis F, Abuchowski A, Van Es T: Enzyme-polyethylene glycol adducts:modified enzymes with unique properties. Enzyme Eng 4:169-173, 1978.
    • (1978) Enzyme Eng , vol.4 , pp. 169-173
    • Davis, F.1    Abuchowski, A.2    Van Es, T.3
  • 44
    • 0019800071 scopus 로고
    • Alteration of the circulating life and antigenic properties of bovine adenosine deaminase in mice by attachment of polyethylene glycol
    • Davis S, Abuchowski A, Park Y: Alteration of the circulating life and antigenic properties of bovine adenosine deaminase in mice by attachment of polyethylene glycol. Clin Exp Immunol 46:649-652, 1981.
    • (1981) Clin Exp Immunol , vol.46 , pp. 649-652
    • Davis, S.1    Abuchowski, A.2    Park, Y.3
  • 45
    • 0021248339 scopus 로고
    • Cancer therapy with chemically modified enzymes: Anti-tumor properties of PEG-LASP conjugates
    • Abuchowski A, Kazo GM, Verhoest Jr. CR: Cancer therapy with chemically modified enzymes: Anti-tumor properties of PEG-LASP conjugates. Cancer Biochem Biophys 7:175-185, 1984.
    • (1984) Cancer Biochem Biophys , vol.7 , pp. 175-185
    • Abuchowski, A.1    Kazo, G.M.2    Verhoest Jr., C.R.3
  • 46
    • 0023146216 scopus 로고
    • Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase
    • Hershfield MS, Buckley RH, Greenberg ML: Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase. N Engl J Med 310:589-596, 1987.
    • (1987) N Engl J Med , vol.310 , pp. 589-596
    • Hershfield, M.S.1    Buckley, R.H.2    Greenberg, M.L.3
  • 47
    • 0027536607 scopus 로고
    • L-asparaginase and PEG asparaginase - past, present, and future. Leuk
    • Keating MJ, Holmes R, Lerner S, Ho DH: L-asparaginase and PEG asparaginase - past, present, and future. Leuk. Lymphoma 10, suppl:153-157, 1993.
    • (1993) Lymphoma , vol.10 , Issue.SUPPL. , pp. 153-157
    • Keating, M.J.1    Holmes, R.2    Lerner, S.3    Ho, D.H.4
  • 48
    • 0023793570 scopus 로고
    • Hemoglobin solutions coupled with polyethylene glycol 1900: Preparation, purification, quality control and pharmacological trials by hemorrhagic shock
    • Labrude P, Mouelle P, Menu P: Hemoglobin solutions coupled with polyethylene glycol 1900: preparation, purification, quality control and pharmacological trials by hemorrhagic shock. Int. J Artif Orgfans 11:393-402, 1988.
    • (1988) Int. J Artif Orgfans , vol.11 , pp. 393-402
    • Labrude, P.1    Mouelle, P.2    Menu, P.3
  • 49
    • 0028940867 scopus 로고
    • Administration of a hemoglobin solution decreases hypoxia and increases radiation response in a rat mammary carcinoma
    • Teicher BA, Dupuis NP, Liu F, Robinson MF, Menon K: Administration of a hemoglobin solution decreases hypoxia and increases radiation response in a rat mammary carcinoma. Drug Dev Res 34:231-240, 1995.
    • (1995) Drug Dev Res , vol.34 , pp. 231-240
    • Teicher, B.A.1    Dupuis, N.P.2    Liu, F.3    Robinson, M.F.4    Menon, K.5
  • 50
    • 0025139690 scopus 로고
    • Preclinical studies relating to the use of thiotepa in the high-dose setting alone and in combination
    • Teicher BA, Holden SA, Eder JP, Herman TS, Antman KH, Frei III E: Preclinical studies relating to the use of thiotepa in the high-dose setting alone and in combination. Semin Oncol 17(1 [suppl 3]): 18-32, 1990.
    • (1990) Semin Oncol , vol.171 , Issue.3 SUPPL. , pp. 18-32
    • Teicher, B.A.1    Holden, S.A.2    Eder, J.P.3    Herman, T.S.4    Antman, K.H.5    Frei III, E.6
  • 51
    • 0021324649 scopus 로고
    • Perfluorochemical emulsions can increase tumor radiosensitivity
    • Teicher BA, Rose CM: Perfluorochemical emulsions can increase tumor radiosensitivity. Science 223:934-936, 1984.
    • (1984) Science , vol.223 , pp. 934-936
    • Teicher, B.A.1    Rose, C.M.2
  • 55
    • 0028070110 scopus 로고
    • Oxygenation of the rat 9L gliosarcoma and the rat 13762 mammary carcinoma with various doses of a hemoglobin solution
    • Teicher BA, Holden SA, Dupuis NP, Kusumoto T, Liu M, Liu F, Menon K: Oxygenation of the rat 9L gliosarcoma and the rat 13762 mammary carcinoma with various doses of a hemoglobin solution. Immob Biotech 22:827-833, 1994.
    • (1994) Immob Biotech , vol.22 , pp. 827-833
    • Teicher, B.A.1    Holden, S.A.2    Dupuis, N.P.3    Kusumoto, T.4    Liu, M.5    Liu, F.6    Menon, K.7
  • 57
    • 0028132666 scopus 로고
    • Reduced oxygenation in a rat mammary carcinoma after chemo- or radiation therapy and reoxygenation with perflubron emulsion/carbogen breathing
    • Teicher BA, Alvarez Sotomayor E, Dupuis N, Kusumoto T, Menon K: Reduced oxygenation in a rat mammary carcinoma after chemo- or radiation therapy and reoxygenation with perflubron emulsion/carbogen breathing. J Cancer Res Clin Oncol 120(10):593-598, 1994.
    • (1994) J Cancer Res Clin Oncol , vol.120 , Issue.10 , pp. 593-598
    • Teicher, B.A.1    Alvarez Sotomayor, E.2    Dupuis, N.3    Kusumoto, T.4    Menon, K.5
  • 61
    • 0024411217 scopus 로고
    • Geometric resistance to blood flow in solid tumors perfused ex vivo: Effects of tumor size and perfusion pressure
    • Sevick EM, Jain RK: Geometric resistance to blood flow in solid tumors perfused ex vivo: Effects of tumor size and perfusion pressure. Cancer Res 49:3513-3519, 1989.
    • (1989) Cancer Res , vol.49 , pp. 3513-3519
    • Sevick, E.M.1    Jain, R.K.2
  • 67
    • 0027261178 scopus 로고
    • Oxygen tension distributions ar sufficient to explain the local response of human breast tumors treated with radiation alone
    • Okunieff P, Hoeckel M, Dunphy EP, Schlenger K, Knoop C, Vaupel P: Oxygen tension distributions ar sufficient to explain the local response of human breast tumors treated with radiation alone. Int J Radiat Oncol Biol Phys 26:631-636, 1993.
    • (1993) Int J Radiat Oncol Biol Phys , vol.26 , pp. 631-636
    • Okunieff, P.1    Hoeckel, M.2    Dunphy, E.P.3    Schlenger, K.4    Knoop, C.5    Vaupel, P.6
  • 68
    • 0027056686 scopus 로고
    • Blood flow and tissue oxygenation of human tumors: An update
    • Vaupel P, Schlenger K, Hoeckel M: Blood flow and tissue oxygenation of human tumors: An update. Adv Exp Med Biol 316:361-371, 1992.
    • (1992) Adv Exp Med Biol , vol.316 , pp. 361-371
    • Vaupel, P.1    Schlenger, K.2    Hoeckel, M.3
  • 72
    • 0029088440 scopus 로고
    • Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymph node metastases
    • Brizel DM, Rosner GL, Prosnitz LR, Dewhirst MW: Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymph node metastases. Int J Radiat Oncol Biol Phys 32(4):1121-1125, 1995.
    • (1995) Int J Radiat Oncol Biol Phys , vol.32 , Issue.4 , pp. 1121-1125
    • Brizel, D.M.1    Rosner, G.L.2    Prosnitz, L.R.3    Dewhirst, M.W.4
  • 73
    • 0023027477 scopus 로고
    • Safety evaluation of free radical scavengers PEG-catalase and PEG-superoxide dismutase
    • Viau A, Abuchowski A, Greenspan S, Davis F: Safety evaluation of free radical scavengers PEG-catalase and PEG-superoxide dismutase. J Free Radic Biol Med 2(4):283-288, 1986.
    • (1986) J Free Radic Biol Med , vol.2 , Issue.4 , pp. 283-288
    • Viau, A.1    Abuchowski, A.2    Greenspan, S.3    Davis, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.