Evidence of differential regulation of p-glycoprotein overexpression in drug-resistant tumour cells selected by exposure to x-lrradiation as opposed to antitumour drugs

Oncology Research and Treatment

Volumn 19, Issue , 1996, Pages 6-9

  Hill, Bridget T ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Drug resistance; Fractionated X irradiation; P glycoprotein; Tumour cell lines

Indexed keywords

ANTINEOPLASTIC AGENT; EPIPODOPHYLLIN DERIVATIVE; GLYCOPROTEIN P; UNCLASSIFIED DRUG; VINCA ALKALOID;

ANIMAL CELL; CHO CELL; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION; GENETIC REGULATION; MULTIDRUG RESISTANCE; NONHUMAN; X RAY;

EID: 0030513045     PISSN: 22965270     EISSN: None     Source Type: Journal    
DOI: 10.1159/000218877     Document Type: Article

References (11)

1. Hill BT: Interactions between antitumour agents and radiation and the expression of resistance, Cancer Treat Rev 1991:18:149-190.
2. Hill BT: In vitro drug-radiation interactions using fractionated X-irradiation regiments: in Hill BT, Bellamy AS (eds): Antitumor Drug-Radiation Interactions, Boca Raton, CRC Press, 1990. pp 207-222.
3. Bellamy AS, Hill BT: Murine L5I78Y cells resulting in altered drug sensitivities from fractionated radiation exposure in vitro, J Natl Cancer Inst 1984:72:411-417.
4. Hill BT: Differing patterns of cross-resistance resulting from exposures to specific antitumour drags or to radiation in vitro, Cytotechnology 1993; 12: 265-288.
5. Hill BT, Deuchards K, Hosking LK, Ling V, Whelan RDH: Overexpression of P-glycoprotein in mammalian tumor cell lines after fractionated X-irradiation in vitro, J Natl Cancer Inst 1990;82:607-612.
6. McClean S, Whelan RDH, Hosking LK, Hodges GM, Thompson FH, Meyers MB, Schuurhuis GJ, Hill BT: Characterisation of the P-glycoprotein overexpressing drag resistance phenotype exhibited by Chinese hamster ovary cells following their in vitro exposure to fractionated X-irradiation, Bio-chirn Biophys Acta 1993;1177:117-126.
7. McClean S, Hosking LK, Hill BT: Dominant expression of multiple drag resistance after in vitro X-irradiation exposure of intraspecific Chinese hamster ovary hybrids, J Natl Cancer Inst 1992:85:48-53.
8. McClean S, Hill BT: Evidence of post-translational regulation of P-glycoprotein associated with the expression of a distinctive multiple drag-resistant phenotype in Chinese hamster ovary cells, Eur J Cancer 1993;29A:2243-2248.
9. Muller C, Ling V: P-glycoprotein is affected by serum deprivation and high cell density in multidrug resistant cells, Proc Am Assoc Cancer Res 1992:33:452.
10. Dempke WCM, Whelan RDH, Hill BT: Expression of resistance to etoposide and vincristine in vitro and in vivo after X-irradiation of ovarian tumour cells, Anti-Cancer Drugs 1992;3:395-399.
11. Hill BT, Whelan RDH, Hurst HC, McClean S: Identification of a distinctive P-gylcoprotein-me-diated resistance phenotype in human ovarian carcinoma cells following their in vitro exposure to fractionated X-irradiation, Cancer 1994:73:2990-2999.