The influence of the chirality of synthetic iron chelators bearing N-hydroxy-2(1H)-pyrazinones and amino acid residues upon iron removal from human transferrin

Chemistry Letters

Volumn , Issue 6, 1996, Pages 423-424

  Ohkanda, Junko ^a   Katoh, Akira ^a  

^a SEIKEI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0030503143     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.1996.423     Document Type: Article

References (9)

1. R. J. Bergeron and G. M. Brittenhamm, The Development of Iron Chelators for Clinical Use, CRC Press, Boca Raton, 1992 and references cited therein.
2. R. E. Cowart, N. Kojima, and G. W. Bates, J. Biol. Chem., 101, 5401(1982).
3. S. A. K. Nguyen, A. Craig, and K. N. Raymond, J. Am. Chem. Soc., 115, 6758(1993).
4. a) J. Ohkanda, T. Tokumitsu, K. Mitsuhashi, and A. Katoh, Bull. Chem. Soc. Jpn., 66, 841(1993).
5. b) J. Ohkanda and A. Katoh, J. Org. Chem., 60, 1583(1995).
6. c) J. Ohkanda and A. Katoh, Tetrahedron, 51, 12995(1995).
7. 2O: C, 53.95; H, 7.70; N, 16.78%.
8. max and ε values were comparable to those of 1:1 iron complexes of 2 (Ref. 4b).
9. obs) was calculated from the slope of the plots of log [(A∞-Abs)/(A∞-A0)] as a function of time. A0: the absorbance at t=0. A∞: the absorbance after 800 min.