Combined use of urinary UGP and serum CA125 in the diagnosis of gynecological cancers

Anticancer Research

Volumn 16, Issue 6 B, 1996, Pages 3833-3838

  Plebani, Mario ^a,b   Navaglia, Filippo ^a   Basso, Daniela ^a   De Paoli, Massimo ^a   Nicoletto, Maria Ornella ^a   Maraglino, Emiliano ^c   Torre, Gian Carlo ^d  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b Center of Biomedical Research   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d SANTA CORONA HOSPITAL   (Italy)

Author keywords

CA 125; Gynecological cancer; Receiver operating characteristic (roc) curves; Sensitivity; Specificity; Tumor marker; UPG

Indexed keywords

CA 125 ANTIGEN; CHORIONIC GONADOTROPIN; CREATININE; TUMOR MARKER;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CREATININE URINE LEVEL; CYSTADENOCARCINOMA; ENDOMETRIUM CARCINOMA; ENZYME IMMUNOASSAY; FEMALE; GYNECOLOGIC CANCER; HUMAN; MAJOR CLINICAL STUDY; MENOPAUSE; OVARY CARCINOMA; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; PROTEIN URINE LEVEL; URINALYSIS; UTERINE CERVIX CARCINOMA; VULVA CARCINOMA;

ADULT; AGED; CA-125 ANTIGEN; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; DIAGNOSIS, DIFFERENTIAL; FEMALE; GENITAL DISEASES, FEMALE; GENITAL NEOPLASMS, FEMALE; HUMANS; MIDDLE AGED; PEPTIDE FRAGMENTS; TUMOR MARKERS, BIOLOGICAL;

EID: 0030499505     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Masure HR, Jaffee WL, Sickel MA, Birken S, Canfield RE, Vaitukaitis JL: Characterization of a small molecular size urinary immunoreactive human chorionic gonadotropin (hCG)-like substance produced by normal placenta and by hCG-secreting neoplasms. J Clin Endocrinol Metab 53:1014-1020, 1981.
2. Kato Y, Braunstein GD: β-core fragment is a major form of immunoreactive urinary chorianic gonadotropin in human pregnancy. J Clin Endocrinol Metab 66: 1197-1201, 1988.
3. Birken S, Armstrong EG, Kolks MAG, Cole LA, Agosto GM, Krichevsky A, Vaitukaitis JL and Canfield RE: Structure of the human chorionic gonadotropin β-subunit fragment from pregnancy urine. Endocrinology 123:572-583, 1988.
4. Kurdana A, Bagshawe KD, Coles B, Read D, Taylor M: Characterization of UGP and its relationship with beta-core fragment. Br J Cancer 67:686-692, 1993.
5. Kardana A, Cole LA: Serum hCG β-core fragment is masked by associated macromolecules. J Clin Endocrinol Metab 71: 1393-1395, 1990.
6. Papapetrou PD and Nicopaulou SC: The origin of a human chorionic gonadotropin β-subunit-core fragment excreted in the urine of patients with cancer. Acta Endocrinol 112:415-422, 1986.
7. Lefort GP, Stolk JM, Nisula BC: Renal metabolism of the β-subunit of human choriogonadotropin in the rat. Endocrinology 119:924-931, 1986.
8. Wehmann RE, Blithe DL, Akar AH and Nisula BC: Disparity between β-core levels in pregnancy urine and serum: implication for the origin of urinary β-core. J Clin Endocrinol Metab 70:371-378, 1990.
9. Cole LA, Birken S: Origin and occurrence of human chorionic gonadotropin β-subunit core fragment. Mol Endocrinol 2:825-830, 1988.
10. Kardana A, Taylor ME, Southall PJ, Boxer GM, Rowan AJ, Bagshawe KD: Urinary gonadotrophin peptide-isolation and purification, and its immunohistochemical distribution in normal and neoplastic tissues. Br J Cancer 58:281-286, 1988.
11. Wehmann RE, Blithe DL, Flack MR, Nisula BC: Metabolic clearance rate and urinary clearance of purified β-core. J Clin Endocrinol Metab 69:510-517, 1989.
12. O' Connor JF, Schlatterer JP, Birken S, Krichevsky A, Armstrong EG, McMahon D and Canfield RE: Development of highly sensitive immunoassays to measure human chorionic gonadotropin, its β-subunit, and β core fragment in the urine: application to malignancies. Cancer Res 48: 1361-1366, 1988.
13. Alfthan H, Stenmann UH: Pregnancy serum contains the β-core fragment of human choriogonadotropin. J Clin Endocrinol Metab 70:783-787, 1990.
14. Lee CL, Iles RK, Shepherd JH, Hudson CN, Chard T: The purification and development of a radioimmunoassay for β-core fragment of human chorionic gonadotrophin in urine: application as a marker of gynecological cancer in premenopausal and postmenopausal women. J Endocrinol 130:481-489, 1991.
15. Dirnhofer S, Madersbacher S, Bidart JM, Ten Kortenaar PBW, Spottl G, Mann K, Wick G, Berger P. The molecular basis for epitopes on the free β-subunit of human chorionic gonadotrophin (hCG), its carboxyl-terminal peptide and the hCGβ-core fragment. J Endocrinol 141:153-162, 1994.
16. Norman RJ, Buck RH, Aktar B, Mayel N, Moodley J: Detection of a small molecular species of human chorionic gonadotropin in the urine of patients with carcinoma of the cervix and cervical intraepithelial neoplasia: comparison with other assays for human chronionic gonadotropin and its fragments. Gynecol Oncol 37:254-259, 1990.
17. Nam JH, Cole LA, Chambers JT, Schwartz PE: Urinary Gonadotropin fragment, a new tumor marker. I. Assay development and cancer specificity. Gynccol Oncol 36:383-390, 1990.
18. Cole LA, Nam JH, Chambers JT, Schwartz PB: Urinary Gonadotropin fragment, a new tumor marker. II. Differentiating a benign from a malignant pelvic mass. Gynecol Oncol 36:391-394, 1990.
19. Nam JH, Chang KC, Chambers JT, Schwartz PE, Cole LA: Urinary Gonadotropin fragment, a new tumor marker. III. Use in cervical and vulvar cancers. Gyneeol Oncol 38:66-70, 1990.
20. Nam JH, Chambers JT, Schwartz PE, Cole LA: Urinary Gonadotropin fragment, a new tumor marker. IV. Use in endometrial cancers and uterine mixed mullerian tumors. Gynecol Oncol 39:352-357, 1990.
21. Plebani M, Navaglia F, Bacelle L, Polonio S, Lazzari F, Marchetti M: Urinary gonadotropin peptide: collection of specimens and cut-off levels. J Clin Lab Anal 9:230-233, 1995.
22. Plebani M, Faggian D, Masiero M, Giacomini A, Burlina A: CA 19-9 and CA125 determination by immunoluminometric assay. J Clin Chem Clin Biochem 28:914-921, 1990.
23. Guenther WC: Analysis of variance. Englewood Cliff, NJ, Prentice-Hall, 1964.
24. Weinstein MC, Fineberg HV: Clinical decision analysis. Philadelphia, WB Saunders, 1980.
25. Carter PG, Iles RK, Neven P, Ind TEJ, Shepherd JH, Chard T: Measurement of urinary beta core fragment of human chorionic gonadotropin in women with vulvovaginal malignancy and its prognostic significance. Br J Cancer 71:350-353, 1995.
26. Walker R, Crebbin V, Stern J, Scudder S, Schwartz P: Urinary gonadotropin peptide (UGP) as a marker of gynecological malignancies. Anticancer Res 14: 1703-1710, 1994.
27. Akar AH, Gervasi G, Blacker C, Wehmann RE, Blithe DL. Nisula BC: Human chohonic gunadotrophin-like and β-core-like materials in postmenupausal urine. J Endocrinol 125:477-484, 1990.
28. Stockell Hartree A, Shownkeen RC: Studies of human pituitary LH containing internally cleaved β subunit. J Mol Endocrinol 6:101-109, 1991.
29. Alfthan H, Haglund C, Dabek J, Stenman UH: Concentrations of human choriogonadotropin, its β-subunit. and the core fragment of the β-subunit in serum and urine of men and nonpregnant women. Clin Chem 38: 1981-1987, 1992.
30. Arbeitsgruppe qualitäts kontrolle und standardisierung von tumor markers tests in rammen der Hamburger Symposien uber tumor-marker. Tumordiagn Ther 5:19-22, 1992.