Immunoblotting characterization of CA125 in biological fluids: Difference between pregnancy and cancer CA 125 origin

Anticancer Research

Volumn 16, Issue 6 B, 1996, Pages 3621-3624

  Barbati, Antonella ^a,c   Lauro, Vincenzo ^a   Orlacchio, Aldo ^a   Cosmi, Ermelando Vinicio ^b  

^a UNIVERSITY OF PERUGIA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c POLICLINICO MONTELUCE   (Italy)

Author keywords

Biological fluids; CA 125; Immunoblotting

Indexed keywords

CA 125 ANTIGEN; GLYCOPROTEIN; PLASMA PROTEIN; TUMOR ANTIGEN;

AMNION FLUID; ANTIGEN EXPRESSION; ARTICLE; BODY FLUID; BREAST MILK; CONTROLLED STUDY; CYST; GEL CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MAJOR CLINICAL STUDY; MOLECULAR WEIGHT; OVARY CANCER; OVARY FOLLICLE FLUID; PERITONEAL FLUID; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALIVA; UTERINE CERVIX MUCUS;

BIOLOGICAL MARKERS; BODY FLUIDS; CA-125 ANTIGEN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HUMANS; IMMUNOBLOTTING; ORGAN SPECIFICITY; PREGNANCY;

EID: 0030499479     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Bast RC, Feeney M, Lazarus H, Nadler LM, Colvin RB, Knapp RC: Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest 68: 1331-1337, 1981.
2. Kabawat SE, Bast RC Jr, Bhan AK, Welch WR, Knapp RC, Colvin RB: Tissue distribution of a coelomic-epithelium related antigen recognized by the monoclonal antibody OC 125. Int J Gynecol Pathol 2: 275-285, 1983.
3. Niloff JM, Knapp RC, Schaetzl E, Reynolds C, Bast RC: CA 125 antigen levels in obstetric and gynecologic patients. Obstet Gynecol 64: 703-707, 1984.
4. Barbieri RL, Niloff JM, Bast RC, Schaetzl E, Kistner RW, Knapp RC: Elevated serum concentration of CA 125 in patients with advanced endometriosis. Fertil Steril 45: 630-634, 1986.
5. Barbati A, Cosmi EV, Spaziani R, Ventura R, Montanino G: Serum and peritoneal fluid CA-125 levels in patients with endometriosis. Fertil Steril 61: 438-442, 1994.
6. Pittaway DE, Fayez JA: Serum CA-125 antigen levels increase during menses. Am J Obstet Gynecol 156: 75-76, 1987.
7. Kobayashi F, Sagawa N, Nakamura K et al: Mechanism and clinical significance of elevated CA 125 levels in the sera of pregnant women. Am J Obstet Gynecol 160: 563-566, 1989.
8. O'Brien TJ, Hardin JW, Bannon GA, Norris JS, Quirk JG: CA 125 antigen in human amniotic fluid and fetal membranes. Am J Obstet Gynecol 155: 50-55, 1986.
9. Barbati A, Anceschi MM, Alberti P, Pomili G, Di Renzo GC, Cosmi EV: Ontogeny of CA 125 antigen in pregnancy: Immunoradiometric determination in amniotic fluid and immunohistochemical localization in fetal membranes. Am J Obst Gynccol 160: 514-517, 1989.
10. Barbati A, Cosmi EV: CA 125 in pregnancy. Anticancer Research 13(5): 1632-1636, 1993.
11. Barbati A, Anceschi MM, Broccucci L, Cosmi EV: CA125 is released by human amnion cells in culture. Am J Obstet Gynccol 162: 266-268, 1990.
12. Barbati A, Broccucci L, Anceschi M, Cosmi EV: Regulation of CA 125 production by amnion and Wish cells in culture. Am J Obstet Gynecol 164: 1355-1359, 1991.
13. Di-Xia C, Schwartz PE, Fan-Qin L: Saliva and serum CA 125 assays for detecting malignant ovarian tumors. Obstet Gynecol 75: 701-704, 1990.
14. Barbati A, Anceschi M, Di Renzo GC, Cosmi EV: CA-125 in peritoneal fluid: Reliable values at high dilutions. Obstet Gynecol 79: 1011-1015, 1992.
15. Fuith LC, Daxenbichler G, Marth C: CA-125 in human milk and serum. Gynceol Obstet Invest 28: 1-3, 1989.
16. de Bruijn HWA, Jager CS, Duk JM, Aalders JG, Fleuren GJ: The tumor marker CA 125 is a common constituent of normal cervical mucus. Am J Obstet Gynecol 154: 1088-1091, 1986.
17. Halila H: Detection of ovarian cancer marker CA 125 in human seminal plasma. Tumor Biol 6: 207-212, 1985.
18. Davis HM, Zurawski VR Jr, Bast RC Jr, Klug TL: Characterization of the CA 125 antigen associated with human epithelial ovarian carcinomas. Cancer Res 46: 6143-6148, 1986.
19. Mojiminiyi OA, Bramwell ME, Kennedy SH, Shepstone BJ, Humm SM, Barlow DH: Immunoreactive determinants of CA 125 in women with endometriosis. J Clin Pathol 42: 1272-1275, 1989.
20. Kobayashi H, Ida W, Terao T, Kawashima Y: Quantitative and qualitative assessmant of CA-125 production by human endometrial epithelial cell:comparison of eutopic and heterotopic epithelial cells. Int J Cancer 54: 426-434, 1993.
21. Barbati A, Di Renzo GC, Cosmi EV: Hook effect in immunoradiometric assay of CA 125 in peritoneal fluid: Evidence of high CA-125 concentrations by a comparative immunoblotting analysis. Clin Chem 39: 1548-1549, 1993.
22. Kobayashi F, Sagawa N, Nakamura K, et al: Mechanism and clinical significance of elevated CA 125 levels in the sera of pregnant women. Am J Obstet Gynecol 160: 563-566, 1989.
23. Tomoda Y, Kanou T, Furuhashi Y, et al: Significance of tumor markers for the treatment of patients with ovarian malignancies. Jpn J Cancer Chemother 14: 3027-3033, 1987.