Inhibition of xanthine oxidase by cytokinins and related substances

Anticancer Research

Volumn 16, Issue 6 B, 1996, Pages 3571-3576

  Sheu, Shiow Yunn ^a,b   Lin, Y U Chan ^a   Chiang, Hsüch Ching ^b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Adenine HCl; Cytokinins; Dihydrozeatin; DNA damage; Gout; Hepatitis; Leukemia; N 6 (2 isopentenyl) adenine; Purine; Tumours; Xanthine oxidase inhibitor

Indexed keywords

ADENINE; ADENOSINE; ALLOPURINOL; CYTOKININ; DIHYDROZEATIN; HYPOXANTHINE; UNCLASSIFIED DRUG; URIC ACID; XANTHINE; XANTHINE OXIDASE; XANTHINE OXIDASE INHIBITOR;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

ADENINE; CYTOKINES; HUMANS; OXIDATION-REDUCTION; PURINES; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHINE OXIDASE;

EID: 0030499352     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Takahashi N, Marumo S and Daigaku N: Physiologically Active Natural Products (in Japanese) In: (Takahashi N ed), Chapter 1.Physiologicaly active substances in plants, Section 1-2, Plant hormones, 1-2iii, Cytokinins. Tokyo: Tokyo University Press, 1973, pp.37-48.
2. Leopald AC and Kriedemann PE: Plant Growth and Development, 2nd ed Chapter 6. Cytokinins. New York: Megraw-Hill Book company, 1976, pp. 155-167.
3. Sheu SY and Chiang HC: Inhibitory effects of plant growth regulators on xanthine oxidase. Anticancer Res 16: 311-316, 1996.
4. Chang WS, Lee YJ, Lu FJ and Chiang HC: Inhibitory effects of flavonoids on xanthine oxidase. Anticancer Res 13: 2165-2170, 1993.
5. Chiang HC and Chen YY: Xanthine oxidase inhibitors from the roots of eggplant (Solanum melongena L.). J. Enzyme Inhibit 7: 225-235, 1993.
6. Chang WS, Chang YH, Lu FJ and Chiang HC: Inhibitory effects of phenolics on xanthine oxidase. Anticancer Res 14: 501-506, 1994.
7. Chiang HC, Lo YJ and Lu FJ: Xanthine oxidase inhibitors from the leaves of Alsophila spinulosa (Hook) Tryon. J. Enzyme Inhibit 8: 61-71, 1994.
8. Colowick SP and Kaplan NO: Methods in Enzymology. Vol. 74. Immunochemical Techniques. Part C edited by Langone JJ and Vanakis HV. In: (Halfman CJ ed), Section II. Data analysis. Chapter 32. Concentrations of binding proteins and labeled analyte that are appropriate for measuring at any analyte concentration range in radioimmunoassays. pp. 481-497, and (Ukraincik K and Piknosh W eds). Chapter 33. Microprocessor-based radioimmunoassay data analysis. Now York; Academic Press Inc, 1981, pp. 447-508.
9. Colowick SP and Kaplan NO: Methods in Enzymology. Vol. 74. Immunochemical Techniques. Part C edited by Langone JJ and Vanakis HV. In: (Halfman CJ ed), Section II. Data analysis. Chapter 32. Concentrations of binding proteins and labeled analyte that are appropriate for measuring at any analyte concentration range in radioimmunoassays. pp. 481-497, and (Ukraincik K and Piknosh W eds). Chapter 33. Microprocessor-based radioimmunoassay data analysis. Now York; Academic Press Inc, 1981, pp. 447-508.
10. Lineweaver H and Burk D: The determinations of enzyme dissociation constants. J Am Chem Soc 56: 658-666, 1934.
11. Bowman WC and Rand MJ: Textbook of Pharmacology, 2nd ed. Chapter I, Constituents of Tissue: Einzyme Kinetics. Australia. Blackwell Scientific Publications, 1980, pp. 1.46-1.511.
12. Segel IH: Biochemical Calculations 2nd ed. In: Chapter 4. Enzyme. Enzyme inhibition. p.250. competitive inhibition: p.260. uncompetitive inhibitions: p.261, mixed type inhibition. New York: John Wiley and Sons, 1976.
13. Segel IH: Biochemical Calculations 2nd ed. In: Chapter 4. Enzyme. Enzyme inhibition. p.250. competitive inhibition: p.260. uncompetitive inhibitions: p.261, mixed type inhibition. New York: John Wiley and Sons, 1976.
14. Segel IH: Biochemical Calculations 2nd ed. In: Chapter 4. Enzyme. Enzyme inhibition. p.250. competitive inhibition: p.260. uncompetitive inhibitions: p.261, mixed type inhibition. New York: John Wiley and Sons, 1976.
15. Segel IH: Biochemical Calculations 2nd ed. In: Chapter 4. Enzyme. Enzyme inhibition. p.250. competitive inhibition: p.260. uncompetitive inhibitions: p.261, mixed type inhibition. New York: John Wiley and Sons, 1976.
16. Klenow H: The enzymic oxidation and assay of adenine. Biochem J 50: 404-407, 1952.
17. Henderson TH, Skinner CG and Eakin RE: Kinetin and kinetin analogues as substrates and inhibitors of xanthine oxidase. Plant Physiol. 37: 552-555, 1962.
18. Faroogi AHA, Shukla YN, Shukla A and Bhakuni DS: Cytokinins from marine organisms. Phytochemistry 29: 2061-2063, 1990.
19. McGaw BA and Horgan R: Cytokinin catabolism and cytokinin oxidase. Pytochemistry 22: 1103-1105, 1983.
20. 2-isopentenyl) adenine. Biochemistry 14: 3088-3093, 1975.
21. Bowman WC and Rand MJ: Textbook of Pharmacology. 2nd ed. Chapter 2. Subcellular organization and cellular metabolism. Degradation of purines. 2.43-2.44. Australia: Blackwell Scientific Publications, 1980.
22. Farrow MG, Blaydes DF and van Dyke, K: The effects of plant growth substances and natural products on RNA and DNA synthesis in leukocytes. Experientia. 32: 29-30, 1976.
23. 6-isopentenyl) adenosine on a cell line derived from circulating leukocytes of a patients with chronic myelogenous leukaemia. Cancer Res 32: 1647-1650, 1972.
24. 2-isopentenyl) adenosine. a natural component of mammalian transfer RNA. Cancer Res. 30: 1429-1436, 1970.
25. Gallo RC, Whang-Pong J and Perry S: Isopentenyl adenosine stimulates and inhibits mitosis of human lymphocytes treated with phytohemagglutinin. Science 165: 400-402, 1969.
26. Jones R Jr, Grace JT Jr, Mittelman A and Woodruff MW: Human pharmacology and initial clinical trial of isopentenyl adenosine. Proc Am Assoc Cancer Res 9: 35, 1968.
27. Al-Khalidi UAS and Geha RS: The sensitivity of serum xanthine oxidase and serum glutamic pyruvic transaminase in detecting liver damage. Clin Chim Acta 14: 833-835, 1966.
28. Shammaës MH, Nasrallah S, Chaglassian T, Kachadurian AK and Al-Khalidi HAS: Serum xanthine oxidase. A sensitive test of acute liver injury, Gastroenterology 48: 226-230, 1965.
29. Ramboer CRH: A sensitive and nonradioactive assay for serum and tissue xanthine oxidase. J Lab and Clin Mod 74: 825-835, 1969.
30. Poggetti RS, Moore FA, Moore EE, Koeike K and Banerjee A: Simultaneous liver and lung injury following gut ischaemia is mediated by xanthine oxidase. J Trauma 32: 723-728, 1992.
31. Kokoglu E, Belce A, Ozyurt E and Tepeler Z: Xanthine oxidase levels in human brain tumors. Cancer Lett 50: 179-181, 1990.
32. Chiricolo M, Tazzari PL, Abbondanza A, Dinota A and Battelli MG: Cytotoxicity of and DNA damage by, active oxygen species produced by xanthine oxidase. FEBS Lett 291: 173-176, 1991.
33. Smith HJ: Design of enzyme inhibitors as drug. In: Xanthine oxidase inhibitors (Sandler M and Smith HJ eds). Oxford. Oxford University Press, 1989, pp 7711-779.
34. Reilly PM, Schiller HJ and Bulkley GB: Pharmacological approach to tissue injury mediated by free radicals and other reactive oxygen metabolites. Am J Surg 161: 488-503, 1991.
35. Bulkley GB: Endothelial xanthine oxidase: a radical transducer of inflammatory signals for reticuloendothelial activation. Br J Surg 80: 684-686, 1993.
36. Floyd RA: Role of oxygen-free radicals in carcinogenesis and brain ischaemia. FASEB J 4: 2587-2597, 1990.