A flow cytometric study of early gastric cancer: The detection of high proliferative activity adds important information to the prognosis

Pathology Research and Practice

Volumn 192, Issue 12, 1996, Pages 1202-1205

  Ranaldi, R ^a,c   Santinelli, A ^a   Fabris, G ^a   Mannello, B ^a   Natoli, C ^b   Tinari, N ^b   Bearzi, I ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c Ospedale Nuovo Regionale   (Italy)

Author keywords

DNA ploidy pattern; Flow cytometry; Gastric cancer; Prognosis; Proliferative activity

Indexed keywords

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CELL CYCLE; CELL CYCLE S PHASE; CELL PROLIFERATION; EARLY CANCER; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PLOIDY; PROGNOSIS; STOMACH CANCER;

EID: 0030498715     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0344-0338(96)80151-8     Document Type: Article

References (27)

1. Aretxaba X, Yonemura Y, Sugiyama K, et al. (1988) DNA ploidy in early gastric cancer and its relationship to prognosis. Br J Cancer 58: 81-84
2. Bearzi I, Ranaldi R (1982) Early gastric cancer: a morphologic study of 41 cases. Tumori 68: 223-233
3. Bearzi I, Ranaldi R, Rezai B, Sassaroli C, Mannello B (1992) AgNORs and PCNA immunoreactivity in early and advanced gastric carcinoma. Acta Stereol 11: 119-124
4. Brito MJ, Rosa JC, Thomas VA, Filipe MI (1994) Quantitative measurement of DNA content in gastric carcinoma; flow cytometry and video image analysis. Anal Cell Pathol 7: 1-9
5. Farley DR, Donohue JH, Nagorney DM, Carpenter HH, Katzmann JA, Ilstrup DM (1992) Early gastric cancer. Br J Surg 79: 539-542
6. Filipe MI, Rosa J, Sandey A, Imrie PR, Ormerod MG, Morris RW (1991) Is DNA ploidy and proliferative activity of prognostic value in advanced gastric carcinoma? Hum Pathol 22: 373-378
7. Fujita S (1978) Biology of early gastric carcinoma. Path Res Pract 163: 297-309
8. Hamilton PW, Wyatt JI, Quirke P, et al. (1992) Morphometry of gastric carcinoma: its association with patient survival, tumour stage, and DNA ploidy. J Pathol 168: 201-208
9. Haraguchi M, Korenaga D, Kakeji Y, Orita H, Maehara Y, Sugimachi K (1991) DNA ploidy is associated with growth potential in gastric carcinoma. Cancer 68: 2608-2611
10. Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove EA (1983) Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Hystochem Cytochem 31: 1333-1335
11. Inokuchi K, Kodama Y, Sasaki O, Kamegawa T, Okamura T (1983) Differentiation of growth patterns of early gastric carcinoma determined by cytophotometric DNA analysis. Cancer 51: 1138-1141
12. Itoh H, Oohata Y, Nakamura K, Nagata T, Mibu R, Nakayama F (1988) Complete ten-year postgastrectomy follow-up of early gastric cancer. Am J Surg 158: 14-16
13. Johansen AA (1976) Early gastric cancer. In: BC Morson (Ed.) Current Topics in Pathology. Pathology of the gastrointestinal tract, pp 1-47: Springer Verlag, Berlin, Heidelberg, New York
14. Kamata T, Yonemura Y, Sugiyama K, et al. (1989) Proliferative activity of early gastric cancer measured by in vitro and in vivo bromodeoxyuridine labeling. Cancer 64: 1665-1668
15. Korenaga D, Okamura T, Saito A, Baba H, Sugimachi K (1988) DNA ploidy is closely linked to tumor invasion, lymph node metastasis, and prognosis in clinical gastric cancer. Cancer 62: 309-313
16. Lauren P (1965) The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Path Microbiol Scand 64: 31-49
17. Murakami T (1971) Pathomorphological diagnosis: Definition and gross classification of early gastric cancer. In: T Murakami (Ed.) Early Gastric Cancer, Gann Monograph on Cancer Research II, pp 53-55, University of Tokyo Press, Tokyo
18. Nakamura K, Sugano H, Takagi K (1968) Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances. Gann 59: 251-258
19. Ohyama S, Yonemura Y, Miyazaki I (1992) Proliferative activity and malignancy in human gastric cancers. Cancer 69: 314-321
20. Ranaldi R, Santinelli A, Verdolini R, Rezai B, Mannello B, Bearzi I (1995) A long-term follow-up study in early gastric cancer: evaluation of prognostic factors. J Pathol 177: 343-351
21. Rugge M, Sonego F, Panozzo M, et al. (1994) Pathology and ploidy in the prognosis of gastric cancer with no extranodal metastasis. Cancer 73: 1127-1133
22. Sano T, Sasako M, Kinoshita T, Maruyama K (1993) Recurrence of early gastric cancer. Follow-up of 1475 patients and review of the japanese literature. Cancer 72: 3174-3178
23. Suarez V, Newman J, Hiley C, Croker J, Collins M (1989) The value of NOR numbers in neoplastic and non neoplastic epithelium of the stomach. Histopathology 14: 61-66
24. Wyatt JI, Quirke P, Ward DC, et al. (1989) Comparison of histopathological and flow cytometric parameters in prediction of prognosis in gastric cancer. J Pathol 158: 195-201
25. Yonemura Y, Kimura H, Fushida S, et al. (1993) Analysis of proliferative activity using anti-proliferating cell nuclear antigen antibody in gastric cancer tissue specimens obtained by endoscopic biopsy. Cancer 71: 2448-2453
26. Yonemura Y, Ooyama S, Sugiyama K, et al. (1990) Retrospective analysis of the prognostic significance of DNA ploidy patterns and S-phase fraction in gastric carcinoma. Cancer Res 50: 509-514
27. Yonemura Y, Sugiyama K, Fujimura T, et al. (1988) Correlation of DNA ploidy and proliferative activity in human gastric cancer. Cancer 62: 1497-1502