Antimitogenic effects of the gastrin-CCK receptors' antagonists L-364718 and L-365260 in human colon cancer cell clone HT29-S-B6: Cell cycle analysis and modulation by serum

Biomedical Research

Volumn 17, Issue 6, 1996, Pages 457-464

  Forgue Lafitte, Marie Elisabeth ^a   Coudray, Anne Marie ^a   Mester, Jan ^a   Gespach, Christian ^a   Rosselin, Gabriel ^a  

^a CENTRE DE RECHERCHE SAINT ANTOINE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; ALPHA METHYL N [(TRICYCLO[3.3.1.1 3,7]DEC 2 YLOXY)CARBONYL]TRYPTOPHYL DEXTRO 3 BENZYL BETA ALANINE; ANTIMITOTIC AGENT; CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ OCTAPEPTIDE; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; DEVAZEPIDE; GASTRIN; GASTRIN ANTAGONIST; LINTITRIPT; PD 135158; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CELL CLONE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL GROWTH; CELL PROLIFERATION; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DOSE RESPONSE; DRUG EFFECT; HUMAN; HUMAN CELL;

EID: 0030498379     PISSN: 03886107     EISSN: None     Source Type: Journal    
DOI: 10.2220/biomedres.17.457     Document Type: Article

References (45)

1. BAISCH H., GÖDE W. and LINDEN W. (1975) Analysis of PCP-data to determine the fraction of cellls in various phases of the cell cycle. Radiat. Environ. Biophys. 12, 31-39
2. BALDWIN G. S. (1994) Antiproliferative gastrin/CCK receptor antagonists target the 78-kDa gastrin-binding protein. Proc. Natl. Acad. Sci. USA 91, 7593-7597
3. BEAUCHAMP R. D., TOWNSEND C. M., SINGH P., GLASS E. J. and THOMPSON J. C. (1985) Proglumide, a gastrin receptor antagonist, inhibits growth of colon cancer and enhances survival in mice. Ann. Surg. 202, 303-309
4. BLACKMORE M., DOHERTY E., MANNING J. E. and HIRST B. H. (1994) Autocrine growth stimulation of human renal Wilms' tumour G401 cell by a gastrin-like peptide Int. J. Cancer 57, 385-391
5. BLACKMORE M. and HIRST B. H. (1992) Autocrine stimulation of growth of AR4-2J rat pancreatic tumour cells by gastrin. Brit. J. Cancer 66, 32-38
6. BOCK M. G., DIPARDO R. M., EVANS B., RITTLE K. E., WHITTER W. L., VEBER D. F., ANDERSON P. S. and FREIDINGER R. M. (1989) Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365260. J. Med. Chem. 32, 13-16
7. BOLD R. J., ISHIZUKA J., TOWNSEND C. M. and THOMPSON J. C. (1994) Gastrin stimulates growth of human colon cancer cells via a receptor other than CCK-A or CCK-B. Biochem. Biophys. Res. Commun. 202, 1222-1226
8. CHANG R. S. L., CHEN T. B., BOCK M. G., FREIDINGER R. M., CHEN R., ROSEGAY A. and LOTTI V. J. (1989) Characterization of the binding of 3H-L-365260: A new potent and selective brain cholecystokinin (CCK-B) and gastrin receptor antagonist radioligand. Mol. Pharmacol. 35, 803-808
9. CHANG R. S. L. and LOTTI V. J. (1986) Biochemical and pharmacological characterization of an extremely potent and selective nonpeptide cholecystokinin antagonist. Proc. Natl. Acad. Sci. USA 83, 4923-4926
10. CHANG R. S. L., LOTTI V. J., MONAGHAN R. L., BIRNBAUM J., STAPLEY E. O., GOETZ M. A., ALBERS-SCHONBERG G., PATCHETT A. A., LIESCH J. M., HENSENS O. D. and SPRINGER J. P. (1985) A potent cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus. Science 230, 177-179
11. CLARKE G. D. and RYAN P. J. (1980) Tranquillizers can block mitogenesis in 3T3 cells and induce differentiation in Friend cells. Nature 287, 160-161
12. D'AGOSTINO L., PIGNATA S., DANIELE B., TRITTO G., D'ADAMO G., CONTEGIACOMO A., ROVATI L., CALDEROPOLI R. and MAZZACCA G. (1994) Modulation of CaCo-2 cell growth and polyamine metabolism by pentagastrin and gastrin antagonists. Cancer J. 7, 32-38
13. DOCKRAY G. J. (1977) Molecular evolution of gut hor-mones: Application of comparative studies on the regulation of digestion. Gastroenterology 72, 344-358
14. EGGSTEIN S., IMDAHL A., KOHLER M., WAIBEL M. and FARTHMANN E. H. (1991) Influence of gastrin, gastrin receptor blockers, epidermal growth factor, and difluoromethylornithine on the growth and the activity of ornithine decarboxylase of colonic cancer cells. J. Cancer Res. Clin. Oncol. 117, 37-42
15. FINLEY G. G, KOSKI R. A., MELHEM M. F., PIPAS J. M. and MEISLER A. I. (1993) Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma. Cancer Res. 53, 2919-2926
16. FORGUE-LAFITTE M.-E., COUDRAY A.-M, BRÉANT B. and MESTER J. (1989) Proliferation of the human colon carcinoma cell line HT29: Autocrine growth and deregulated expression of the c-myc oncogene. Cancer Res. 49, 6566-6571
17. FORGUF-LAFITTE M.-E., COUDRAY A.-M., FAGOT D. and MESTER J. (1992) Effects of ketoconazole on the proliferation and cell cycle of human cancer cell lines. Cancer Res. 52, 6827-6831
18. FORGUE-LAFITTE M.-E., COUDRAY A.-M., JANNEAU J.-L. et BARA J. (1994) Expression des mucines gastriques (antigènes M1) par le sous-clone HT29-SB6 cultivé sans sérum. Gastmentérol. Clin. Biol. 18, 44
19. GULLY D., FRÉHEL D., MARCY C., SPINAZZÉ A., LESPY L., NELIAT G., MAFFRAND J.-P. and LE FUR G. (1993) Peripheral biological activity of SR27897: a new potent non-peptide antagonist of CCK-A receptors. Eur. J. Pharmacol. 232, 13-19
20. HILSTED L. and REHFELD J. F. (1986) Measurement of precursors for alpha-amidated hormones by radioimmunoassay of glycine-extended peptides after trypsin-carboxypeptidase cleavage. Anal. Biochem. 152, 119-126
21. HOOSEIN N. M., KIENER P. A., CURRY R. C., ROVATI L. C., MCGILBRA D. K. and BRATTAIN M. G. (1988) Antiproliferative effects of gastrin receptor antagonists and antibodies to gastrin on human colon carcinoma cell lines. Cancer Res. 48, 7179-7183
22. HOOSEIN N. M., KIENER P. A., CURRY R. C. and BRATTAIN M. G. (1990) Evidence for autocrine growth stimulation of cultured colon tumor cells by a gastrin/cholecystokinin-like peptide. Exp. Cell Res. 186, 15-21
23. HUANG S. C., ZHANG L., CHIANG H. C. V., WANK S. A., MATON P. N., GARDNER J. D. and JENSEN R. T. (1989) Benzodiazepine analogues L-365260 and L-364718 as gastrin and pancreatic CCK receptor antagonists. Amer. J. Physiol. 257, G169-G174
24. HUGHES J., BODEN P., COSTALL B., DOMENY A., KELLY E., HORWELL D. C., HUNTER J. C., PINNOCK R. D. and WOODRUFF G. N. (1990) Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc. Natl. Acad. Sci. USA 87, 6728-6732
25. IMDAHL A., EGGSTEIN S. T., CRONE C. and FARTHMANN E. H. (1989) Growth of colorectal carcinoma cells: regulation in vitro by gastrin, pentagastrin and the gastrin receptor antagonist proglumide. J. Cancer Res. Clin. Oncol. 115, 388-392
26. ISHIZUKA J., TOWNSEND C. M., BOLD R. J., MARTINEZ J., RODRIGUEZ M. and THOMPSON J. C. (1994) Effects of gastrin on 3′-5′-cyclic adenosine monophosphate, intracellular calcium, and phosphatidyl inositol hydrolysis in human colon cancer cells. Cancer Res. 54, 2129-2135
27. JOHNSON L. R. (1977) Gastrointestinal hormones and their functions. Annu. Rev. Physiol. 39, 135-158
28. KOCHMAN M. L., DEL VALUE J., DICKINSON C. J. and BOLAND C. R. (1992) Post-translational processing of gastrin in neoplastic human colonic tissues. Biochem. Biophys. Res. Commun. 189, 1165-1169
29. LOTTI V. J. and CHANG R. S. L. (1989) A new potent and selective non peptide gastrin antagonist and brain CCK-B receptor ligand: L-365260. Eur. J. Pharmacol. 162, 273-280
30. MAUSS S., NIEDERAU C. and HENGELS K. J. (1994) Effects of gastrin, proglumide, and L-364260 on growth of human colon carcinoma cells. Anticancer Res. 14, 215-220
31. MIETTINEN H., KONONEN J., HAAPASALO H., HELEN P., SALLINEN P., HARJUNTAUSTA T., HELIN H. and ALBO H. (1995) Expression of peripheral-type benzodiazepine receptor and diazepam binding inhibitor in human astrocytomas: relationship to cell proliferation. Cancer Res. 55, 2691-2695
32. NÈGRE F., FAGOT-REVURAT P., BOUISSON M., REHFELD J. F., VAYSSE N. and PRADAYROL L. (1996) Autocrine stimulation of AR4-2J pancreatic tumor cell growth by glycine-extended gastrin. Int. J. Cancer 66, 653-658
33. NEMETH J., TAYLOR B., PAUWELS S., VARRO A. and DOCKRAY G. J. (1993) Identification of progastrin derived peptides in colorectal carcinoma extracts. Gut 34, 90-95
34. REMY-HEINTZ N., PERRIER-MEISSONNIER S., NONOTTE I., LALIBERTÉ M.-F., CHEVILLARD C., LABOISSE C. and BALI J.-P. (1993) Evidence for autocrine stimulation by a gastrin/CCK-like peptide of the gastric cancer HGT-1 cell line. Mol. Cell. Endocrinol 93, 23-29
35. SEVA C., DICKINSON C. J. and YAMADA T. (1994) Growth-promoting effects of glycine-extended progastrin. Science 265, 410-412
36. SEVA C., SCEMAMA J. L., BASTIÉ M. J., PRADAYROL L. and VAYSSE N. (1990) Lorglumide and loxiglumide inhibit gastrin-stimulaled DNA synthesis in a rat tumoral acinal pancreatic cell line (AR42J). Cancer Res. 50, 5829-5833
37. SINGH P., LE S., BEAUCHAMP R. D., TOWNSEND C. M. and THOMPSON J. C. (1987) Inhibition of pentagastrin-stimulated up-regulation of gastrin receptors and growth of mouse colon tumor in vivo by proglumide, a gastrin receptor antagonist. Cancer Res. 47, 5000-5004
38. SINGH P., OWLIA A., ESPEIJO R. and DAI B. (1995) Novel gastrin receptors mediate mitogenic effects of gastrin and processing intermediates of gastrin on Swiss 3T3 fibroblasts. Absence of detectable cholecystokinin (CCK)-A and CCK-B receptors. J. Biol. Chem. 270, 8429-8438
39. SINGH P., XU Z., DAI B., RAJARAMAN S., RUBIN N., and DHRUVA B. (1994) Incomplete processing of progastrin expressed by human colon cancer cells: role of noncarboxiaminated gastrins. Amer. J. Physiol. 29, G459-G468
40. SMITH J. P. and SOLOMON T. E. (1988) Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer. Gastroenterology 95, 1541-1548
41. THUMWOOD C. M., HONG J. and BALDWIN G. S. (1991) Inhibition of cell proliferation by the cholocystokinin antagonist L-364718. Exp. Cell Res. 192, 189-192
42. VAN SOLINGE W. W., NIELSEN F. C., FRIIS-HANSEN L., FALKMER U. G. and REHFELD J. F. (1993) Expression but incomplete maturation of progastrin in colorectal carcinomas. Gastmentemlogy 104, 1099-1107
43. WANG J. K. T., MORGAN J. I. and SPECTOR S. (1984) Benzodiazepines that bind at peripheral sites inhibit cell prolif-eration. Proc. Natl. Acad. Sci. USA 81, 753-756
44. WANK S. A. (1995) Cholecystokinin receptors. Amer. J. Physiol. 32, G628-G646
45. WATSON S. A., CROSBEE D. M., MORRIS D. L., ROBERTSON J. F. R., MAKOVEC F., ROVATI L. C. and HARDCASTLE J. D. (1992) Therapeutic effect of the gastrin receptor antagonist, CR2093 on gastrointestinal tumour cell growth. Brit. J. Cancer 65, 879-883