Organotypic rat brain culture as in vivo-like model system

Methods in Cell Science

Volumn 18, Issue 4, 1996, Pages 283-291

  Fennrich, Stefan ^a   Stier, Heike ^a   Föhr, Karl Josef ^a   Ray, David ^b   Ghersi Egea, Jean François ^c   Schlosshauer, Burkhard ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Brain; Histology; Organotypic culture; Patch clamp recording; Rat

Indexed keywords

LACTATE DEHYDROGENASE;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL SIZE; CYTOARCHITECTURE; ELECTROPHYSIOLOGY; ENZYME ASSAY; EXPLANT; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; MODEL; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICOLOGY; NONHUMAN; ORGAN CULTURE; PATCH CLAMP; PHARMACOLOGY; RAT; SCANNING ELECTRON MICROSCOPY;

ANIMALIA; MAMMALIA;

EID: 0030497940     PISSN: 13815741     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00127905     Document Type: Article

References (36)

1. Aschner M, Kimelberg HK (1991). The use of astrocytes in culture as model systems for evaluating neurotoxic-induced-injury. Neurotoxicology 12: 505-518.
2. Chambers JE, Chambers HW, Snawder JE (1991). Target site bioactivation of the neurotoxic organophosphorus insecticide parathion in partially hepatectomized rats. Life Sci 48: 1023-1029.
3. Cookman GR, Regan CM (1991). Studies of the antiproliferative action of inorganic lead in relation to the phases of the rat glial cell cycle. Toxic Vitro 5: 127-132.
4. Daston GP, Baines D, Yonker JE (1991). Chick embryo neural retina cells as a screen for developmental toxicity. Toxicol Appl Pharmacol 109: 352-366.
5. Denker L, Nau H, D'Argay R (1990). Marked accumulation of valproic acid in embryonic neuroepithelium of the mouse during early organogenesis. Teratology 41: 699-706.
6. Donald JM, Hooper K, Hopenhayn-Rich C (1991). Reproductive and developmental toxicity of toluene: A review. Environ Health Perspect 94: 237-244.
7. Flint OP, Orton TC (1984). An in vitro assay for teratogens with cultures of rat embryo midbrain and limb bud cells. Toxicol Appl Pharmacol 76: 383-395.
8. Fountain SB, Ting Y-LT, Teyler TJ (1992). The in vitro hippocampal slice preparation as a screen for neurotoxicity. Toxic Vitro 6: 77-87.
9. Föhr KJ, Schirm T, Finger W (1995). NMDA-induced whole-cell currents and single channel conductances in tectal neurons during two stages of early development of chicken. Neurosci Lett 183: 87-90.
10. Gähwiler BH (1988). Organotypic cultures of neural tissue. Trends Neurosci 11: 484-489.
11. Kelly PG, Regan CM (1992). Studies on valproateinduced perturbations of neurulation in the explanted chick embryo. Toxicol 71: 137-144.
12. Khera KS (1987). Neuronal degeneration caused by ethylenethiourea in neuronal monocell layers in vitro and in fetal brain in vivo. Teratology 36: 87-93.
13. Knöpfel T, Rietschin L, Gähwiler BH (1989). Organotypic co-cultures of rat locus coeruleus and hippocampus. Eur J Neurosci 1: 678-689.
14. Lärkfors L, Oskarsson A, Sundberg J, Ebendal T (1991). Methylmercury induced alterations in the nerve growth factor level in the developing brain. Dev Brain Res 62: 287-291.
15. Lindström H, Luthman J, Oskarsson A, Sundberg J, Olson L (1991). Effects of long-term treatment with methyl mercury on the developing rat brain. Environ Res 56: 158-169.
16. Mitchell DB, Santone KS, Acosta D (1980). Evaluation of cytotoxicity in cultured cells by enzyme leakage. J Tiss Cult Meth 6: 113-116.
17. Newell DW, Hsu SS, Papermaster V, Malouf AT (1993). Colchicine is selectively neurotoxic to dentate granule cells in organotypic cultures of rat hippocampus. Neurotoxicology 14: 375-380.
18. Nostrandt AC, Ehrich M (1992). Development of a model cell culture system in which to study early effects of neuropathy-inducing organophosphorus esters. Toxicol Lett 60: 107-114.
19. Paxinos G, Watson, C (1986). The rat brain in stereotaxic coordinates. San Diego, CA: Academic Press; Harcourt Brace Jovanovich, 2nd edn.
20. Prasad KN (1991). New opportunities with neuronal cultures to study the mechanisms of neurotoxic injuries. Neurotoxicology 12: 493-504.
21. Repetto G, Sanz P, Repetto M (1993). In vitro effects of mercuric chloride and methylmercury chloride on neuroblastoma cells. Toxicol In Vitro 7: 353-357.
22. Schlosshauer B, Bauch H, Frank R (1995). Neurothelin: Amino acid sequence, cell surface dynamics and actin colocalization. Eur J Cell Biol 68: 159-166.
23. Schlosshauer B, Blum AS, Mendez-Otero R, Barnstable CJ, Constantine-Paton M (1988). Developmental regulation of ganglioside antigens recognized by the JONES antibody. J Neurosci 8: 580-592.
24. Schlosshauer B, Herzog K-H (1990). Neurothelin: An inducible cell surface glycoprotein of blood-brain barrier-specific endothelial cells and distinct neurons. J Cell Biol 110: 1261-1274.
25. Selvín-Testa A, Lopez-Costa JJ, Nessi de Avinon AC, Pecci Saavedra J (1991). Astroglial alterations in rat hippocampus during chronic lead exposure. Glia 4: 384-392.
26. Sharma RP, Obersteiner EJ (1977). Acrylamide cytotoxicity in chick ganglia cultures. Toxicol Appl Pharmacol 42: 149-156.
27. Sieber SM, Whang-Peng J, Botkin C, Knutsen T (1978). Teratogenic and cytogenetic effects of some plant-derived antitumor agents (vincristine, colchicine, maytansine, VP-16-213 and VM-26) in mice. Teratology 18: 31-48.
28. Simpson IA, Sonne O (1982). A simple, rapid and sen-sitive method for measuring protein concentration in subcellular membrane fractions prepared by sucrose density ultracentrifugation. Anal Biochem 119: 424-427.
29. Singer TP, Ramsay RR (1990). Mechanism of the neurotoxicity of MPTP. FEBS Lett 274: 1-8.
30. Singer TP, Ramsay RR, McKeown K, Trevor A, Castagnoli NE Jr (1988). Mechanism of the neurotoxocity of 1 -methyl-4-phenylpyridinium (MPP+), the toxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydorpyridine (MPTP). Toxicol 49: 17-23.
31. Smith RA (1991). Primary cultures of adult mammalian sensory neurons and other in vitro systems of use in neurotoxicological studies. Arch Toxicol Suppl 14: 8-14.
32. Snawder JE, Chambers JE (1989). Toxic and developmental effects of organophosphorus insecticides in embryos of the south african clawed frog. J Environ Sci Health 24: 205-218.
33. Tanii H, Hashimoto K (1992). In vitro neurotoxicity study with dorsal root ganglia for acrylamide and its derivatives. Toxicol Lett 58: 209-213.
34. Walum E, Peterson A (1984). On the cell application of cultured neuroblastoma cells in chemical toxicity screening. J Toxicol Environ Health 13: 511-520.
35. Wyle-Gyurech GG, Reinhardt CA (1991). Differentiation of embryonic chick brain cells in monolayer and reaggregate cultures: A potential model in vitro for neurotoxicity. Toxic Vitro 5: 419-425.
36. Zajac CS, Abel EI (1990). Lack of lead effects on fetal development and offspring learning when combined with alcohol in the Long-Evans rat. Teratology 41: 33-41.