Sulphatide and its precursor galactosylceramide influence the production of cytokines in human mononuclear cells

APMIS

Volumn 104, Issue 12, 1996, Pages 938-944

  Buschard, Karsten ^a   Diamant, Marcus ^b   Bovin, Lone F ^b   Månsson, Jan Eric ^c   Fredman, Pam ^c   Bendtzen, Klaus ^b  

^a Kommunehospitalet ^*  (Denmark)

^b Rigshospitalet   (Denmark)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

blood mononuclear cells; cytokines; galactosylceramide; IL 6 mRNA; interleukin 6 (IL 6); sulphatide

Indexed keywords

CYTOKINE; GALACTOSYLCERAMIDE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; PHYTOHEMAGGLUTININ; SULFATIDE;

ARTICLE; AUTOIMMUNITY; BLOOD CELL; CONTROLLED STUDY; ETIOLOGY; HUMAN; HUMAN CELL; INFLAMMATION; MONOCYTE; NORMAL HUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL;

EID: 0030484776     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1699-0463.1996.tb04962.x     Document Type: Article

References (28)

1. Bendtzen, K., Mandrup-Poulsen, T., Nerup, J., Nielsen, J. H., Dinarello, C. A. & Svenson, M.: Human pl 7 interleukin 1 is cytotoxic for pancreatic islets of Langerhans. Science 232: 1545-1547, 1986.
2. Buschard, K., Aaen, K., Horn, T., van Damme, J. & Bendtzen, K.: Interleukin 6 is a functional and structural modulator of beta-cells from islets of Langerhans. Autoimmunity 5: 185-194, 1990.
3. Buschard, K., Josefsen, K., Horn, T. & Fredman, P.: Sulphatide and sulphatide antibodies in insulin-dependent diabetes mellitus. Lancet 342: 840, 1993a.
4. Buschard, K., Josefsen, K., Horn, T., Larsen, S. & Fredman, P.: Sulphatide antigen in islets of Langerhans and in diabetic glomeruli, and anti-sulphatide antibodies in Type 1 diabetes mellitus. APMIS 101: 963-970, 1993b.
5. Buschard, K., Josefsen, K., Hansen, S. V., Horn, T., Marshall, M. O., Persson, H., Månsson, J.-E. & Fredman, P.: Sulphatide in islets of Langerhans and in organs affected in diabetic late complications: a study in human and animal tissue. Diabetologia 37: 1000-1006, 1994.
6. Buschard, K., Horn, T., Aaen, K., Josefsen, K., Persson, H. & Fredman, P.: Presence of sulphatide (3'sulphogalactosylceramide) in pericytes in the choroid layer of the eye: sharing of this glycolipid autoantigen with islets of Langerhans. Diabetologia 39: 658-666, 1996.
7. Burger, K. N., van der Bijl, P. & van Meer, G.: Topology of sphingolipid galactosyltransferases in ER and Golgi: transbilayer movement of monohexosyl sphingolipids is required for higher glycosphingolipid biosynthesis. J. Cell. Biol. 133: 15-28, 1996.
8. Fredman, P., Vedeler, C. A., Nyland, H., Aarli, J. A. & Svennerholm, L.: Antibodies in sera from patients with inflammatory demyelinating polyradiculoneuropathy react with ganglioside LM1 and sulphatide of peripheral nerve myelin. J. Neurol. 238: 75-79, 1991.
9. Hannum, Y. A.: The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem. 269: 3125-3129, 1994.
10. Hansen, M. B., Svenson, M., Diamant, M. & Bendtzen, K.: Anti-interleukin-6 antibodies in normal human serum. Scand. J. Immunol. 33: 777-781, 1991.
11. Heegaard, P. M. H. & Müller, K.: Lectins and the immune system. EOS. J. Immunol. Immunopharmacol. 4: 239-247, 1988.
12. Laudanna, C., Constantin, G., Baron, P., Scarpini, E., Scarlato, G., Cabrini, G., Dechicchi, C., Rossi, F., Cassatella, M. A. & Berton, G.: Sulphatide triggers increase of cytosolic free calcium and enhances expression of tumor necrosis factor-α and interleukin-8 mRNA in human neutrophils. J. Biol. Chem. 269: 4021-4026, 1994.
13. Laulederkind, S. J. F., Bielawska, A., Raghow, R., Hannum, Y. A. & Ballau, L. R.: Ceramide induces interleukin 6 gene expression in human fibroblasts. J. Exp. Med. 182: 599-604, 1995.
14. Mandrup-Poulsen, T., Nerup, J., Reimers, J. I., Pociot, F., Andersen, H. U., Karlsen, A., Bjerre, U. & Bergholdt, R.: Cytokines and the endocrine system. II. Roles in substrate metabolism, modulation of thyroidal and pancreatic endocrine cell functions and autoimmune endocrine diseases. Eur. J. Endocrinol. 134: 21-30, 1996.
15. Mathias, S., Younes, A., Kann, C.-C., Orlow, L., Joseph, C. & Kolesnik, R. N.: Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta. Science 259: 519-522, 1993.
16. McMaster, G. K. & Carmichael, G. G.: Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. Proc. Natl. Acad. Sci. USA 74: 4835-4838, 1977.
17. Månsson, J.-E., Mo, H., Egge, H. & Svennerholm, L.: Trisialosyllactosylceramide (GT3) is a ganglioside of human lung. FEBS Lett. 196: 259-262, 1986.
18. Rieneck, K., Diamant, M., Haahr, P.-M., Schönharting, M. & Bendtzen, K.: In vitro immunomodulatory effects of pentoxifylline. Immunol. Lett. 37: 131-138, 1993.
19. Rothwell, N. J., Luheshi, G. & Toulmond, S.: Cytokines and their receptors in the central nervous system: physiology, pharmacology, and pathology. Pharmacol. Ther. 69: 85-95, 1996.
20. Sandler, S., Bendtzen, K., Eizirik, D. L. & Welsh, M.: Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro. Endocrinology 126: 1288-1294, 1990.
21. Satoh, T., Nakamura, S., Taga, T., Matsuda, T., Hirano, T., Kishimoto, T. & Kaziro, Y.: Induction of neuronal differentiation of PC12 cells by B cell stimulatory factor 2/interleukin 6. Mol. Cell. Biol. 8: 3546-3549, 1988.
22. Schattner, A.: Lymphokines in autoimmunity - A critical review. Clin. Immunol. Immunopathol. 70: 177-189, 1994.
23. Sekizuka, K., Tonino, Y., Sei, C., Kurusit, A., Tashiro, K., Yamaguchi, Y., Kodera, S., Hishiki, T., Shirato, I. & Koide, H.: Detection of serum IL-6 in patients with diabetic nephropathy. Nephron 68: 284-285, 1994.
24. Slegers, H. & Joniau, M.: Lipopolysaccharide-enhanced expression of interleukin-6 in dibutyryl cyclic AMP-differentiated rat C6 glioma. J. Neurochem. 66: 466-473, 1996.
25. Suzuki, D., Miyazake, M., Naka, R., Koji, T., Yagame, M., Jende, K., Endoh, M. & Nomoto, Y.: In situ hybridization of interleukin-6 in diabetic nephropathy. Diabetes 44: 1233-1238, 1995.
26. Svennerholm, L. & Fredman, P.: A procedure for the quantitative isolation of brain gangliosides. Biochim. Biophys. Acta 617: 97-109, 1980.
27. Vos, J. P., Lopes-Cardozo, M. & Gadella, B. M.: Metabolic and functional aspects of sulphogalactolipids. Biochem. Biophys. Acta 1211: 125-149, 1994.
28. Yamada, M. & Hatanaka, H.: Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death. Brain Res. 643: 173-180, 1994.