Inhibition of nitric oxide synthesis reduces intravenous cocaine self-administration in the rat

Neuropharmacology

Volumn 35, Issue 12, 1996, Pages 1811-1814

  Pulvirenti, Luigi ^a,b,c   Balducci, Claudia ^a   Koob, George F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

cocaine; drug dependence; l NAME; nitric oxide

Indexed keywords

COCAINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG SELF ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; COCAINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; OPIOID-RELATED DISORDERS; RATS; RATS, WISTAR; REWARD; SELF ADMINISTRATION;

EID: 0030483731     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00152-9     Document Type: Article

References (11)

1. Caine S.B., Lintz R. and Koob G.F. (1993) Intravenous drug self-administration techniques in animals. In: Behavioral Neuroscience: A Practical Approach. (Sahgal A. Ed), pp. 117-143. Oxford University Press, Oxford.
2. Dwyer M.A., Bredt D.S., Snyder S.H. Nitric oxide synthase: irreversible inhibition by L-Ng-nitroarginine in brain in vitro and in vivo. Biochem. Biophys. Res. Commun. 176:1991;1136-1141.
3. Garthwaite J. Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci. 14:1991;60-67.
4. 3H]-dopamine from striatal slices. Neuroreport. 3:1992;409-412.
5. Herman B.H., Vocci F., Bridge P. The effects of NMDA receptor antagonists and nitric oxide synthase inhibitors on opioid tolerance and withdrawal. Neuropsychopharmacology. 13:1996;269-293.
6. Kim H.S., Park W.K. Nitric oxide mediation of cocaine-induced dopaminergic behaviors: ambulation-accelerating activity, reverse tolerance and conditioned place preference in mice. J. Pharmacol. Exp. Ther. 275:1995;551-557.
7. Maldonado R., Robledo P., Chover A.J., Caine S.B., Koob G.F. D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. Pharmacol. Biochem. Behav. 45:1993;239-242.
8. Pulvirenti L., Maldonado R., Koob G.F. NMDA receptors in the nucleus accumbens modulate intravenous cocaine, but not heroin self-administration in the rat. Brain Res. 594:1992;327-330.
9. Pulvirenti L., Berrier R., Kriefeldt M., Koob G.F. Modulation of locomotor activity by NMDA receptors in the nucleus accumbens core and shell regions of the rat. Brain Res. 664:1994;231-236.
10. Roberts D.C.S., Loh E.A., Vickers G. Self-administration of cocaine in a progressive ratio schedule. Psychopharmacology. 97:1989;535-538.
11. Youngren K.D., Daly D.A., Moghaddam B. Distinct actions of endogenous excitatory aminoacids on the outflow of dopamine in the nucleus accumbens. J. Pharmacol. Exp. Ther. 264:1993;289-293.