Cytokine expression in multiple myeloma and monoclonal gammopathy: Analysis by reverse transcription/polymerase chain reaction and quantitative PCR

Leukemia and Lymphoma

Volumn 24, Issue 1-2, 1996, Pages 111-120

  Soutar, Richard L ^a   Dillon, John M ^a,b,c   Brown, Domenyk ^a   Ralston, Stuart H ^a  

^a Dept of Haematology and Medicine ^*  (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c ABERDEEN ROYAL INFIRMARY   (United Kingdom)

Author keywords

Cytokines; Interleukin 6; Monoclonal gammopathy; Myeloma; Osteoporosis

Indexed keywords

COLONY STIMULATING FACTOR 1; CYTOKINE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LYMPHOTOXIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; OSTEOPOROSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; CASE-CONTROL STUDIES; CYTOKINES; FEMALE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; LYMPHOTOXIN-ALPHA; MACROPHAGE COLONY-STIMULATING FACTOR; MALE; MULTIPLE MYELOMA; NEOPLASM PROTEINS; OSTEOPOROSIS, POSTMENOPAUSAL; PARAPROTEINEMIAS; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030481753     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199609045719     Document Type: Article

References (40)

1. Bataille, R., Chappard, D., Msrcelli, C., Dessauw, P., Baldet, P , Sany, J. and Alexandre, C. (1991) Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma. Journal of Clinical Investigation, 88, 62-66.
2. Klein, B. and Bataille, R. (1992). Cytokine network in human multiple myeloma. In Multiple Myeloma Hematology/Oncology Clinics of North America, 6, pp 273-284. (Philadelphia, WB Saunders).
3. Hirano, T., Taga, T., Nakano, K., Yasukawa, K , Kashiwamura, S., Shimizu, K , Nakajima, K., Pyun, K. H. and Kishimoto T. (1985). Purification to homogeneity and characterisation of human B-cell differentiation factor (BCDF or BSFp-2), Proceedings of the National Academy of Science of the USA, 82, 5490-5494.
4. Bataille, R., Jourdan, M., Zhang, X-G, and Klein, B. (1989). Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflection of disease severity in plasma cell dyscrasias, Journal of Clinical Investigation, 84, 2008-2011.
5. Nachbaur, D. M., Herold, M., Maneschg, A. and Huber, H. (1991). Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: corrrelation with disease activity and other prognostic parameters, Annals of Hematology, 62, 54-58.
6. Teppo, A.-M., Metsarinne, K. and Fyhrquist F. (1991). Radioimmunoassay of interleukin-6 in plasma, Clinical Chemistry, 37, 1691-1695
7. Solary, E., Guiget, M., Zeller, V., Casasnovas, R.-O , Caillot, D., Chavanet, P , Guy, H. and Mack, G. (1992). Radioimmunoassay for the measurement of serum IL-6 and its correlation with tumour cell mass parameters in multiple myeloma, American Journal of Hematology, 39, 163-171.
8. Ludwig, H., Nachbaur, D. M., Fritz, E , Krainer, M. and Huber, H. (1991). Interleukin-6 is a prognostic factor in multiple myeloma, Blood, 77, 2794-2795.
9. Thaler, J., Fechner, F., Herold, M and Huber, H. (1994). Interleukin-6 in multiple myeloma: correlation with disease activity and Ki-67 proliferation index, Leukemia and Lymphoma, 12, 265-271.
10. Reibnegger, G., Krainer, M., Herold, M., Ludwig, H., Wachter, H. and Huber, H. (1991). Predictive value of interleukin-6 and neopterin in patients with multiple myeloma, Cancer Research, 51, 6250-6253.
11. Pelliniemi, T.-T., Iriala, K., Mattila, K., Pulkki, K , Rajamaki, A., Tienhaara, A., Laakso, M. and Lahtinen, R. (1993). Serum immunoreactive interleukin-6 (IL-6) and acute phase proteins as prognostic factors in multiple myeloma, Blood, 82 (suppl 1), 262a.
12. Kyle, R. A. (1994). Why better prognostic features for multiple myeloma are needed, Blood, 83, 1713-1716.
13. Brown, R., Joshua, D., Uhr, E , Snowdon, L. and Gibson, J. (1991). The use of a commercially available immunoassay to determine the level of interleukin-6 in the serum of patients with myeloma, Leukemia and Lymphoma, 5, 151-155.
14. Merico, F., Bergui, L., Gregoretti, M. G., Ghia, P., Aimo, G., Lindley, I. J. D. and Caligaris-Cappio, F. (1993). Cytokines involved in the progression of multiple myeloma, Clinical and Experimental Immunology, 92, 27-31
15. Ballester, O F , Moscinski, L. C , Lyman, G H., Chaney, J. V., Saba, H. I , Spiers, A. S. D. and Klein, C. (1994). High levels of Interleukin-6 are associated with low tumour burden and low growth fraction in multiple myeloma, Blood, 83, 1903-1908.
16. Ishimi, Y., Miyaura, C., Jin, C H , Akatsu, T., Abe, E., Nakamura, Y , Yamaguchi, A., Yoshiki, S , Matsuda, T., Hirano, T , Kishimoto, T. and Suda, T. (1990). IL-6 is produced by osteoblasts and induces bone resorption, Journal of Immunology, 145, 3297-3303.
17. Garrett, I. R , Durie, B. G M., Nedwin, G. E. Gillespie, A., Bringman, T., Sabatini, M., Bertoloini, D. R and Mundy, G R. (1987). Production of lymphotoxin, a bone resorbing cytokine, by cultured human myeloma cells, New England Journal of Medicine, 317, 526-532.
18. Kawano, M , Yamamoto, I., Iwato, K., Tanaka, H., Asaoku, H., Tanabe, O., Ishikawa, H., Nobuyoshi, M., Ohmoto, Y., Hirai, Y. and Kuramoto, A. (1989). Interleukin-1 beta rather than lymphotoxin as the major bone resorbing activity in human multiple myeloma, Blood, 73, 1646-1649.
19. Cozzolino, F., Torcia, M., Aldinucci, D., Rubartelli, A., Miliani, A., Shaw, A., Lansdorp, P. and Di Guglielmo, R (1989). Production of Interleukin-1 by bone marrow myeloma cells, Blood, 74, 380-387.
20. Portier, M., Zhang, X-G., Ursule, E., Lees, D , Jourdan, M., Bataille, R. and Klein, B. (1993). Cytokine expression in human multiple myeloma, British Journal of Haematology, 85, 514-520.
21. Medical research council's working party on leukaemia in adults. (1980). Prognostic features in the third MRC myelomatosis trial, British Journal of Cancer, 42, 831-840.
22. Chomczynski, P. and Sacchi, N. (1987). Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction, Annals of Biochemistry, 162, 156-159
23. Kwok, S. and Higuchi, R. (1989). Avoiding false positives with PCR, Nature, 339, 237-238.
24. Deveraux, J., Haeberli, P. and Smithies, O. (1984). A comprehensive set of sequence analysis for the VAX, Nucleic Acids Research, 12, 387-395.
25. Ralston, S. H. (1994). Analysis of gene expression in human bone biopsies by polymerase chain reaction: evidence for enhanced cytokine expression in postmenopausal osteoporosis, Journal of Bone and Mineral Research, 9, 883-890.
26. Wang, A. M., Doyle, M. V. and Mark, D F. (1989). Quantitation of mRNA by the polymerase chain reaction, Proceedings of The National Academy of Science of the United Sates of America, 86, 9717-9721.
27. Horton, R. M., Hunt, H. D , Ho, S. N., Pullen, J. K. and Pease, L. R. (1989). Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap etension, Gene, 77, 61-68
28. Piatak, M., Luk, K.-C., Williams, B. and Lifson, J. D. (1993). Quantitative competitive polymerase chain reaction for accurate quantitation of HIV DNA and RNA species, BioTechniques, 14, 70-79.
29. Klein, B., Zhang, X.-G., Lu, Z.-Y. and Bataille, R. (1995). Interleukin-6 in human multiple myeloma, Blood, 85, 863-872.
30. Al-Humidan, A., Ralston, S. H., Hughes, D. E., Chapman, K., Aarden, L., Russell, R. G. G. and Gowen, M. (1991). Interleukin-6 does not stimulate bone resorption in neonatal mouse calvariae, Journal of Bone and Mineral Research, 6, 3-7.
31. Kyle, R. A. (1975). Multiple myeloma. Review of 869 cases, Mayo Clinic Proceedings, 50, 29-40.
32. Soutar, R. L., Wilson, B. and Dawson, A. A. (1993). Myeloma in North East Scotland revisited, British Journal of Haematology, 84 (suppl 1), 45.
33. Kawano, M., Hirano, T., Matsuda, T., Taga, T., Horii, Y., Iwato, K., Asaoku, H., Tang, B., Tanabe, O., Tanaka, H., Kuramoto, A. and Kishimoto T. (1988). Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas, Nature, 332, 83-84.
34. Zhang, X.-G., Klein, B. and Bataille, R. (1989). Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma, Blood, 74, 11-13.
35. Suematsu, S., Matsuda, T., Aozasa, K., Akira, S., Nakano, N., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T. and Kishimoto, T. (1989). IgG1 plasmacytosis in interleukin 6 transgenic mice, Proceedings of The National Academy of Science of the United States of America, 86, 7547-7551.
36. Klein, B., Wijdenes, J., Zhang, X.-G., Jourdan, M., Boiron, J.-M., Brochier, J., Liautard, J., Merlin, M., Clement, C , Morel-Fournier, B., Lu, Z.-Y , Mannoni, P., Sany, J. and Bataille, R. (1991). Murine anti-interleukin - 6 monoclonal antibody therapy for a patient with plasma cell leukaemia, Blood, 75, 1198-1204.
37. Janowska-Wieczorek, A., Belch, A. R , Jacobs, A., Bowen, D., Padua, R.-A., Paietta, E. and Stanley, E. R. (1991). Increased circulating colony-stimulating factor-1 in patients with preleukaemia, leukaemia, and lymphoid malignancies, Blood, 77, 1796-1803.
38. Freeman, G. J., Freedman, A. S., Rabinowe, S. N., Segil, J. M., Horowitz, J., Rosen, K., Whitman, J. F and Nadler, L. M. (1989). Interleukin 6 gene expression in normal and neoplastic B cells, Journal of Clinical Investigation, 83, 1512-1518.
39. Klein, B , Zhang, X.-G., Jourdan, M., Content, J., Houssiau, F., Aarden, L., Piechaczyk, M. and Bataille, R. (1989). Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by Interleukin-6, Blood, 73, 517-526
40. Suzuki, A., Takahashi, T., Okuno, Y., Fukumoto, M., Fukui, H., Koishihara, Y., Ohsugi, Y , Ohno, Y. and Imura, H. (1991). Estimation of Interleukin 6 production by reverse transcription-polymerase chain reaction in four human myeloma cell lines, Leukaemia Research, 15, 1043-1050.