Weibull function fits to pharmacokinetic data of ribavirin in man

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 21, Issue 3, 1996, Pages 227-231

  Liu, X D ^a   Xie, L ^a   Han, K Q ^a   Liu, G Q ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Pharmacokinetics; Ribavirin; Weibull function

Indexed keywords

ANTIVIRUS AGENT; RIBAVIRIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; STATISTICAL ANALYSIS;

EID: 0030481390     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03189718     Document Type: Article

References (8)

1. Huffman J.H , et al. (1973) : In vitro effect of 1-β-D-ribofuranosyl-1,2,4,-triazole-3-carboxamide on deoxyribonucleic acid and ribonucleic acid viruses. Antimicrob. Agents Chemother., 3, 235-241.
2. Sidwell R.W., et al. (1972) : Broad-spectrum antiviral activity of virazole: 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide. Science, 177, 705-706.
3. Laskin O.L , et al. (1987) : Ribavirin disposition in high-risk patients for acquired immunodeficiency syndrome. Clin. Pharmacol. Ther., 419 546-555.
4. Pitrovskii V K (1987) : Pharmacokinetic stochastic model with Weibull distributed residence tunes of the drug molecules in the body. Eur. J. Clin. Pharmacol., 32, 515-523.
5. Granich G.C., et al. (1989) : High performance liquid chromatography assay for ribavirin and comparison of the HPLC assay with radioimmunoassay. Antimicrob Agents Chemother., 33, 311-115
6. Yang Y.C., et al. (1983) : A non-linear method and its program for calculating pharmacokinetic parameters. Acta Pharmacol. Sin., 4, 220-225.
7. Zeng Y.L. (1980) : Two aspects about curve fitting in pharmacokinetics: weighting of experimental data and discrimination between linear compartmental model. Acta Pharm. Sin., 15, 571-576.
8. Yamaoka K., et al. (1978) : Application of Akaike's information criterion in the evaluation of linear pharmacokinetic equations. J. Pharmacokinet. Biopharm., 6, 165-175.