The effect of food on the relative bioavailability of deflazacort

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 21, Issue 3, 1996, Pages 241-245

  Rao, N ^a   Eller, M ^a   Arumugham, T ^a   Weir, S ^a  

^a SANOFI   (France)

Author keywords

Bioavailability; Corticosteroids; Deflazacort; Food effects; Pharmacokinetics

Indexed keywords

21 DEACETYLDEFLAZACORT; DEFLAZACORT; DRUG METABOLITE; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG METABOLISM; FOOD; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIPID DIET; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; TABLET;

EID: 0030481317     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03189720     Document Type: Article

References (8)

1. Hahn B.H., Pletscher L.S., Muniain M. 1981 : Immunosuppressive effects of deflazacort - a new glucocorticoid with bone-sparing and carbohydrate-sparing properties: comparison with prednisolone. J. Rheumatol., 8, 783-790.
2. Guenther H.L., Felix R., Fleisch H. 1984 : Comparative study of deflazacort and dexamethasone on the synthesis of collagen by different bone cell populations and chondrocytes. Calcif. Tissue Int., 36, 145-152.
3. Pagano G., Lombardi A., Ferraris G.M., Imbimbo B., Carvallo P.P. 1982 : Acute effect of prednisolone and deflazacort on glucose tolerance in prediabetic subjects. Eur. J Clin. Pharmacol., 22, 469-471.
4. Martinelli E., Ferrari P., Ripamonti A., Tuan G., Perazzi A., Assandro A. 1979 : Metabolism of deflazacort in the rat, dog and man, Drug Metab. Dispos., 7, 335-339.
5. Canali S., Assandri A., Giachetti C., Zanolo G., Imbimbo B. 1990 : Absolute oral bioavailability of deflazacort (Flantadin®) in the healthy volunteer, Eur. J. Drug Metab. Dispos., 15 (Suppl.), 14.
6. Davis S.S., Hardy J.G., Fara J. 1986 : Transit of pharmaceutical dosage forms through the small intestine, Gut, 27, 886-892.
7. Al-Habet S M , Rogers H.J. 1989 : Effect of food on the absorption and pharmacokinetics of prednisolone from enteric-coated tablets, Eur. J. Clin. Pharmacol., 37, 423-426.
8. Rowland M., Tozer T. 1989 : Absorption, Clinical Pharmacokinetics, 2nd edn. Philadelphia, Lea & Febiger, 125-128.