Effect of Z-100, an immunomodulator extracted from human type tubercle bacilli, on the pulmonary metastases of Lewis lung carcinoma in attempt to regulate suppressor T cells and suppressor factor, EL-4

Biotherapy

Volumn 9, Issue 4, 1996, Pages 249-255

  Emori, Yutaka ^a   Sasaki, Hidetaka ^b   Hayashi, Yoshiro ^a   Nomoto, Kikuo ^b  

^a ZERIA PHARMACEUTICAL CO LTD   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Immunomodulator; Mycobacterium tuberculosis; Pulmonary metastasis; Suppressor cell; Z 100

Indexed keywords

ANTIMETASTATIC AGENT; IMMUNOMODULATING AGENT; INTERLEUKIN 4; MONOCLONAL ANTIBODY; SUPPRESSOR FACTOR; Z 100;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CANCER GRAFT; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; LEWIS CARCINOMA; LUNG METASTASIS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; SUPPRESSOR CELL; SURVIVAL RATE;

ADJUVANTS, IMMUNOLOGIC; ADOPTIVE TRANSFER; ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, LEWIS LUNG; HUMANS; INTERLEUKIN-4; LIPIDS; LUNG NEOPLASMS; MALE; MANNANS; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES, REGULATORY;

EID: 0030481020     PISSN: 0921299X     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02620738     Document Type: Article

References (26)

1. Roth JA. Tumor induced immunosuppression. Surg. Gynecol. Obstet. 1983; 156: 233-240.
2. Kobatake H, Suekane T, Murakami Y, Niwa S, Okahira A and Kushida H. Studies on hot water extract of Mycobacterium tuberculosis. I. Structural analyses of polysaccharides. YakugakuZasshi 1981; 101: 713-722.
3. Suzuki I, Okuda M, Matumura A and Kushida H. Effect of SSM, an extract from human type tubercle bacilli, on the granuropectic activity of the reticuloendothelial system. I. The carbon clearance activity in male mice. Pharmacometrics 1977; 14: 363- 367.
4. Miyamoto R, Ohya O, Hayashi Y, Kushida H, Takahashi M and Nomoto K. Effect of SSM on hematopoietic recovery in Xray irradiated mice (abstract). Proceeding of Japanese Cancer Association, the 46th Annual Meeting, Tokyo, 1987; p.386
5. Kawamura I, Mitsuyama M and Nomoto K. Enhanced protection of cyclophosphamide-treated mice against infection with Pseudomonas aeruginasa after treatment with Z-100, a polysaccharide-rich extract from Mycobacterium tuberculosis AoyamaB. Inununotoxicol. 1990; 12: 331-343.
6. Wada J, Sasaki H, Hayashi Y, Kushida H, Takahashi M and Nomoto K. Induction of interleukin 1 activity by an immunomodulator, SSM, extracted from Mycobacterium tuberculosis human type in mice (abstract). Proceeding of Japanese Cancer Association, the 46th Annual Meeting, Tokyo, 1987; p.386
7. Sasaki H, Schmitt D, Hayashi Y, Pollard RB and Suzuki F. Induction of interleukin 3 and tumor resistance by SSM, a cancer immunotherapeutic agent extracted from Mycobacterium tuberculosis. Cancer Res. 1990; 50; 4032-4037.
8. + T-cells from mice treated with SSM, an immunomodulator extracted human type tubercle bacilli. Anticancer Res. 1990; 10: 285-290.
9. Hayashi Y, Ebina T, Suzuki F and Ishida N. Interferon inducing activity of an immunotherapeutic anticancer agent, SSM, prepared from Mycobacterium tuberculosis strain Aoyama B. Microbiol. Immunol. 1981; 25: 305-316.
10. Sasaki H, Schmitt DA, Kobayashi M, Hayashi Y, Pollard RB and Suzuki F. Prolongation of concomitant antitumor immunity in mice treated with Z-100, an arabinomannan extracted from Mycobacterium tuberculosis . Nat. Immun. 1993; 12: 152167.
11. Satoh H. Antitumor activity of an extract from tubercle bacilli of human type (Maruyama vaccine, or SSM) on ascites hepatomas in rats. Cancer Chemother. 1978; 5: 545-548.
12. + T- cells in the antitumor activity of an immunomodulator, SSM, extracted from human-type tubercle bacilli. J. Natl. Cancer Inst. 1986; 77:441
13. Shimizu T, Hayashi Y, Kushida H, Takahashi M, Neda K, Ohtaki Y, Ohtaka T, Nakayoshi H and Nomoto K. Antitumor effect of SSM, extract from Mycobacterium tuberculosis strain Aoyama B and its effective mechanism (abstract). Proceeding of Japanese Cancer Association, the 46th Annual Meeting, Tokyo, 1987;p.l53.
14. Kobayashi M, Pollard RB and Suzuki F. Inhibition of lung metastases of B16 melanoma by an immunomodulatory arabinomannan extracted fromM. tuberculosis (Z-100) (Abstract). J. Immunol. 1993; 150: p.309A.
15. + T-cells demonstrated in mice late after thermal injury. Immunol. Lett. 1988; 19: 33-40.
16. + suppressor-inducer T-cells. Cancer Res. 1988; 48: 1671-1675.
17. Salgame P, Abrams JS, Clayberger C, Goldstein H, Convit J, Modlin RL and Bloom BR. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 1991; 254: 279-282.
18. Suzuki F, Kobayashi M and Pollard RB. Effect of interleukin 4 (IL-4) on lung metastases in murine B16 melanoma (Abstract). J. Immunol. 1993; 150: p.218A.
19. Kawakami Y, Custer MC, Rosenberg SA and Lotze M. IL-4 regulates IL-2 induction of lymphokine-activated killer activity from human lymphocytes. J. Immunol. 1989; 142: 34523461.
20. Widmer MB and Grabstein H. Regulation of cytolytic T- lymphocyte generation by B-cell stimulatory factor. Nature 1987; 326: 795- 798
21. Golumbek PT, Lazenby AJ, Levitsky HI, Jaffee LM, Karasuyama H, Baker M and Pardoll DM. Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science 1991; 254: 713-716.
22. Mosmann TR and Coffman RL. Heterogeneity of cytokine secretion patterns and functions of helper T-cells. Adv. Immunol. 1989; 46: 111-147.
23. Fernandez-Botran R, Sanders VM, Mosmann TR and Vitetta ES. Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells. J. Exp. Med. 1988; 168: 543-558.
24. Kobayashi M, Herndon DN, Pollard RB and Suzuki F. Z-100, a lipid-arabinomannan extracted from Mycobacterium tuberculosis, improves the resistance of thermally injured mice to herpes virus infections. Immunol. Lett. 1994; 40: 199-205.
25. Kobayashi M, Nakajima N, Pollard RB and Suzuki F. Tumor immunotherapeutic lipid-arabinomannan extracted from Mycobacterium tuberculosis (Z-100) induce the production of IL- 12. (Abstract). Proceeding of the American Association for Cancer Research 1995; 36: 467.
26. Trinchieri G. Interleukin-12 and its role in the generation of TU l cells. Immunol. Today 1993; 14: 335-338.