P53 gene mutations in chronic myelogenous leukemia medullary and extramedullary blast crisis

Leukemia and Lymphoma

Volumn 24, Issue 1-2, 1996, Pages 175-182

  Marasca, Roberto ^a   Luppi, Mario ^a   Barozzi, Patrizia ^a   Ferrari, Maria Grazia ^a   Morselli, Monica ^a   Torelli, Giuseppe ^a,b  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Chronic myelogenous leukemia; CML; Extramedullary blast crisis; P53; Peripheral blast crisis; Point mutations

Indexed keywords

DNA; PROTEIN P53;

ARTICLE; BLAST CELL; BLAST CELL CRISIS; BONE MARROW CELL; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SOUTHERN BLOTTING; TUMOR SUPPRESSOR GENE;

BLAST CRISIS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; BONE MARROW DISEASES; DISEASE PROGRESSION; GENE REARRANGEMENT; GENES, P53; HUMANS; LEUKEMIA, MYELOID, CHRONIC; LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; SEQUENCE ANALYSIS, DNA;

EID: 0030480372     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199609045726     Document Type: Article

References (30)

1. Yin, Y., Tainsky, M. A., Bischoff, F. Z., Strong, L. C. and Wahl, G M. (1992). Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles, Cell, 70, 937-948.
2. Yonish-Rouach, E., Resnitzky, P., Lotem, J., Sachs, L., Kimchi, A. and Oren, M. (1991). Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin 6, Nature, 352, 345-347
3. Soddu, S., Blandino, G., Citro, G., Scardigli, R., Piaggio, G., Ferber, A., Calabretta, B. and Sacchi, A. (1994). Wild-type p53 gene expression induces granulocytic differentiation of HL-60 cells, Blood, 83, 2230-2237.
4. El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W and Vogelstein, B. (1992). Definition of a consensus binding site for p53, Nature Genetics, 1, 45-49.
5. Barak, Y., Juven, T., Haffner, R. and Oren, M. (1993). Mdm-2 expression is induced by wild-type p53 activity, EMBO J., 12, 461-468.
6. Kastan, M. B., Zhan, Q., El-Deiry, W S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B. and Fornace, A. J., Jr. (1992). A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia, Cell, 71, 587-597.
7. El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W. and Vogelstein, B. (1993). WAF1, a potential mediator for p53 tumor suppression, Cell, 75, 817-825.
8. Harper, J. W., Adami, G. R., Wei, N., Keyormarsi, K. and Elledge, S J. (1993). The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinase, Cell, 75, 805-816.
9. Seto, E., Usheva, A., Zambetti, G. P., Momand, J., Horikoshi, N., Weinmann, R., Levine, A. J. and Shenk, T. (1992). Wild-type p53 binds to the TATA-bindmg protein and represses transcription, Proc. Natl. Acad. Sci. USA, 89, 12028-12032.
10. Hollstein, M., Sindranski, D., Vogelstein, B. and Harris, C. C. (1991). p53 mutations in human cancers, Science, 253, 49-53.
11. Imamura, J., Miyoshi, I. and Koeffler, H. P. (1994). p53 in hematologic malignancies, Blood, 84, 2412-2421.
12. Daley, G. Q , van Etten, R. A and Baltimore, D. (1990). Induction of chronic myelogenous leukemia in mice by the p210 bcr-abl gene of the Philadelphia chromosome, Science, 247, 824-830.
13. Ahuja, H., Bar-Eli, M., Advani, S. H., Benchimol, S. and Cline, M. J. (1989). Alterations of the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia, Proc. Natl. Acad. Sci. USA, 86, 6783-6787.
14. Kelman, Z., Prokocimer, M., Peller, S., Kahn, Y., Rechavi, G., Manor, Y., Cohen, A. and Rotter, V. (1989). Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia, Blood, 74, 2318-2324.
15. Ahuja, H., Bar-Eli, M., Arlin, Z., Advani, S., Allen, S. L., Goldman, J., Snyder, D., Foti, A. and Cline, M. (1991). The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia, J. Clin. Invest., 87, 2042-2047.
16. Feinstein, E., Cimino, G., Gale, R. P., Alimena, G., Berthier, R., Kishi, K., Goldman, J , Zaccaria, A., Berrebi, A. and Canaani, E. (1991). p53 in chronic myelogenous leukemia in acute phase, Proc. Natl. Acad. Sci. USA, 88, 6293-6297.
17. Neubauer, A., He, M., Schmidt, C. A., Huhn, D. and Liu, E. T. (1993) Genetic alterations in the p53 gene in the blast crisis of chronic myelogenous leukemia: analysis by polymerase chain reaction based techniques, Leukemia, 7, 593-600.
18. Gaidano, G., Serra, A. Guerrasio, A., Rege-Cambrin, G., Mazza, U. and Saglio, G. (1994). Genetic analysis of p53 and RB1 tumor-suppressor genes in blast crisis of chronic myeloid leukemia, Ann Hematol., 68, 3-7
19. Murakami, Y., Hayashi, K., Hirohashi, S. and Sekiya, T. (1991). Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas, Cancer Res, 51, 5520-5525.
20. Marasca, R., Longo, G., Luppi, M., Barozzi, P. and Torelli, G. (1994) Double P53 point mutation in extramedullary blast crisis of chronic myelogenous leukemia, Leuk. Lymph., 16, 171-175.
21. Mashal, R., Shtalrid, M., Talpaz, M., Kantarjian, H., Smith, L., Beran, M., Cork, A., Trujillo, J . Gutterman, J. and Deisseroth, A. (1990). Rearrangement and expression of p53 in the chronic phase and blast crisis of chrome myelogenous leukemia, Blood, 75, 180-189.
22. Hernandez, A., Hernandez, P., Corral, L , Muniz, A , Alaez, C., Espinosa, E., Fernandez, O. and Martinez, G. (1993). p53 gene rearrangements in chronic myelocytic leukemia, Ann. Hematol., 66, 81-83
23. Foti, A., Ahuja, H. G., Allen, S. L., Koduru, P., Schuster, M. W., Schulman, P., Bar-Eli, M. and Cline, M. J. (1991). Correlation between molecular and clinical events in the evolution of chronic myetocityc leukemia to blast crisis, Blood, 77, 2441-2444.
24. Nakai, H., Misawa, S., Toguchida, J., Yandell, D. W. and Ishizaki, K. (1992). Frequent p53 gene mutations in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome 17p, Cancer Res , 52, 6588-6593.
25. Mori, N., Wada, M., Yokota, J., Terada, M., Okada, M., Teramura, M., Masuda, M., Hoshino, S., Motoji, T., Oshimi, K. and Mizoguchi, H. (1992). Mutations of the p53 tumor suppressor gene in haematologic neoplasms, Br. J. Haemat , 81, 235-240.
26. Schutte, J., Opalka, B., Becher, R. Bardenheuer, W., Szymanski, S , Lux, A and Seeber, S. (1993). Analysis of the p53 gene in patients with isochromosome 17q and Ph1-positive or negative myeloid leukemia, Leukemia Res., 17, 533-539.
27. Nakagawa, H., Fujii, H., Nakai, H., Inazawa, J. and Misawa, S. (1994). Myelomonocytic crisis with t(5;17) and a p53 mutation in a patient with chronic myelogenous leukemia, Am. J. Hematol., 45, 335-340.
28. Tanaka, K., Takauchi, K , Takechi, M., Dohy, H. and Kamada, N. (1992). Chronic myelocytic leukemia with myeloblastoma has higher frequency of RAS oncogene mutation, Leukemia Res., 16, 947
29. Caron de Frommentel, C. and Soussi, T. (1992). TP53 tumor suppressor gene: a model for investigating human mutagenesis, Genes Chrom. Cancer, 4, 1-15.
30. The Italian Cooperative Study Group on Chronic Myeloid Leukemia. (1994) Interferon Alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia, N. Engl. J. Med., 330, 820-825.