Muscarine receptor activation in the substantia gelatinosa of the spinal trigeminal nucleus of the guinea pig

Journal of Neurophysiology

Volumn 76, Issue 6, 1996, Pages 3817-3822

  Travagli, R Alberto ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBACHOL; MUSCARINIC RECEPTOR; PIRENZEPINE;

ANIMAL TISSUE; ARTICLE; DEPOLARIZATION; EXCITATORY POSTSYNAPTIC POTENTIAL; GUINEA PIG; HYPERPOLARIZATION; INHIBITORY POSTSYNAPTIC POTENTIAL; INTRACELLULAR RECORDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SUBSTANTIA GELATINOSA; SYNAPTIC POTENTIAL; TRIGEMINAL NUCLEUS;

EID: 0030479897     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1996.76.6.3817     Document Type: Article

References (44)

1. AIMONE, L. D. AND GEBHART, G. F. Stimulation-produced spinal inhibition from the midbrain in the rat is mediated by an excitatory amino acid neurotransmitter in the medial medulla. J. Neurosci. 6: 1803-1813, 1986.
2. BABA, H., YOSHIMURA, M., NISHI, S., AND SHIMOJI, K. Synaptic responses of substantia gelatinosa neurones to dorsal column stimulation in rat spinal cord in vitro. J. Physiol. Lond. 478: 87-99, 1994.
3. BARBER, R. P., PHELPS, P. E., HOUSER, C. R., CRAWFORD, C. W., SALVATERRA, P. M., AND VAUGHN, J. E. The morphology and distribution of neurons containing choline acetyltransferase in the adult rat spinal cord: an immunocytochemical study. J. Comp. Neurol. 229: 329-346, 1984.
4. BARTOLINI, A., GHEALRDINI, C., FANTETTI, L., MALCANGIO, M., MALMBERG-AIELLO, P., AND GIOTTI, A. Role of muscarinic receptor subtypes in central nociception. Br. J. Pharmacol. 105: 77-82, 1992.
5. BENNETT, G. J., ABDELMOUMENE, M., HAYASHI, H., AND DUBNER, R. Physiology and morphology of substantia gelatinosa neurons intracellularly stained with horseradish peroxidase. J. Comp. Neurol. 194: 809-827, 1980.
6. BLEAZARD, L. AND MORRIS, R. The effects of cholinoceptor agonists on C-fibre evoked responses in the substantia gelatinosa of neonatal rat spinal cord slices. Br. J. Pharmacol. 110: 1061-1066, 1993.
7. BORGES, L. F. AND IVERSEN, S. D. Topography of choline acetyltransferase immunoreactive neurons and fibers in the rat spinal cord. Brain Res. 362: 140-148, 1986.
8. BOUCHENAFA, O. AND LIVINGSTON, A. The autoradiographic binding of [3H] quinuclidinyl benzylate to muscarinic receptors in the spinal cord of the sheep. J. Vet. Pharmacol. Ther. 14: 345-350, 1991.
9. BUCKLEY, N. J., BONNER, T. I., BUCKLEY, C. M., AND BRANN, M. R. Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol. Pharmacol. 35: 469-476, 1989.
10. DORJE, F., WESS, J., LAMBRECHT, G., TACKE, R., MUTSCHLER, E., AND BRANN, M. R. Antagonist binding profiles of five cloned humman muscarinic receptor subtypes. J. Pharmacol. Exp. Ther. 256: 727-733, 1991.
11. GIESLER, G. J., MENETREY, D., GUILBAUD, G., AND BESSON, J.-M. Lumbar cord neurons at the origin of the spinothalamic tract in the rat. Brain Res. 118: 320-324, 1976.
12. GILLBERG, P. G., GORDH, T., HARTVIG, P., JANSSON, I., PETTERSSON, J., AND POST, C. Characterization of the antinociception induced by intrathecally administered carbachol. Pharmacol. Toxicol. 64: 340-343, 1989.
13. GILLBERG, P. G. AND WIKSTEN, P. Effects of spinal cord lesions and rhizotomies on cholinergic and opiate binding sites in rat spinal cord. Acta Physiol. Scand. 126: 575-582, 1986.
14. GOBEL, S. Golgi studies of the neurons in layer II of the dorsal horn of the medulla (trigeminal nucleus caudalis). J. Comp. Neurol. 180: 395-414, 1978.
15. GOBEL, S., FALLS, W. M., BENNETT, G. J., ABDELMOUMENE, M., HAYASHI, H., AND HUMPHREY, E. An EM analysis of the synaptic connections of horse-radish peroxidase-filled stalked cells and islet cells in the substantia gelatinosa of adult cat spinal cord. J. Comp. Neurol. 194: 781-807, 1980.
16. GREEN, P. G. AND KITCHEN, L. Antinociception, opioids and the cholinergic system. Prog. Neurobiol. 26: 119-146, 1986.
17. GRUDT, T. J. AND WILLIAMS, J. T. μ-Opioids inhibit spinal trigeminal substantia gelatinosa neurons in guinea pig and rat. J. Neurosci. 14: 1646-1654, 1994.
18. GRUDT, T. J., WILLIAMS, J. T., AND TRAVAGLI, R. A. Inhibition by 5-hydroxytryptamine and noradrenaline in the substantia gelatinosa of the guinea pig spinal trigeminal nucleus. J. Physiol. Lond. 485: 113-120, 1995.
19. HARRIS, E. W. AND COTMAN, C. W. Effects of acidic aminoacid antagonists on paired pulse potentiation at the lateral perforant path. Exp. Brain Res. 52: 455-460, 1983.
20. JONES, S. L. Descending control of nociception. In: The initial Processing of Pain and Its Descending Control: Spinal and Trigeminal Systems, edited by A. R. Light. Basel: Karger, 1992, p. 203-295.
21. KANAZAWA, I., SUTO, D., OSHIMA, D., AND SAITO, S. Effect of transection on choline acethyltransferase, TRH and substance P in the cat cervical spinal cord. Neurosci. Lett. 13: 325-330, 1979.
22. KATZ, B. The transmission of impulses from nerve to muscle, and the subcellular unit of synaptic action. Proc. R. Soc. 155: 455-477, 1962.
23. LAZARENO, S. AND ROBERTS, S. S. Functional and binding studies with muscarinic M2-subtype selective antagonists. Br. J. Pharmacol. 98: 309-317, 1989.
24. LIGHT, A. R. AND KAVOOKJIAN, A. M. Morphology and ultrastructure of physiologically identified substantia gelatinosa (lamina II) neurons with axons that terminate in deeper dorsal horn lamina (III-IV). J. Comp. Neurol. 267: 172-189, 1988.
25. LIGHT, A. R. AND PERL, E. R. Reexamination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of coarse and fine fibers. J. Comp. Neurol. 186: 117-132, 1979.
26. MCKINNEY, M., ANDERSON, D., AND VELLA-ROUNTREE, L. Different agonist-receptor active conformation for rat brain M1 and M2 muscarinic receptors that are separately coupled to two biochemical effector systems. Mol. Pharmacol. 35: 39-47, 1989.
27. MYSLINSKI, N. R. AND RANDIC, M. Responses of identified spinal neurons to achetylcholine applied by micro-electrophoresis. J. Physiol. Lond. 269: 195-219, 1977.
28. PAN, Z. Z. AND WILLIAMS, J. T. Muscarine hyperpolarizes a subpopulation of neurons by activating an M2 muscarinic receptor in rat nucleus raphe magnus in vitro. J. Neurosci. 14: 1332-1338, 1994.
29. QUIRION, R., ARAUJO, D., REGENHOLD, W., AND BOKSA, P. Characterization and quantitative autoradiographic distribution of [3H] acetylcholine muscarinic receptors in mammalian brain. Apparent labeling of an M2-like receptor subtype. Neuroscience 29: 271-289, 1989.
30. RIBEIRO-DA-SILVA, A. AND CUELLO, A. C. Choline acetyltransferase immunoreactive profiles are presynaptic to primary sensory fibers in the rat superficial dorsal horn. J. Comp. Neurol. 295: 370-384, 1990.
31. SHERRIFF, F. E., HENDERSON, Z., AND MORRISON, J. F. B. Further evidence for the absence of a descending cholinergic projection from the brainstem to the spinal cord in the rat. Neurosci. Lett. 128: 52-56, 1991.
32. SMITH, M. D., YANG, X., NHA, X. Y., AND BUCCAFUSCO, J. J. Antinociceptive effects of spinal cholinergic stimulation: interaction with substance P. Life Sci. 45: 1255-1261, 1989.
33. SUGIURA, Y., LEE, C. L., AND PERL, E. R. Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin. Science Wash. DC 234: 358-361, 1986.
34. TODD, A. J. Immunohistochemical evidence that acetylcholine and glycine exist in different populations of GABAergic neurons in lamina III of rat spinal dorsal horn. Neuroscience 44: 741-746, 1991.
35. TODD, A. J. AND SULLIVAN, A. C. Light microscope study of the coexistence of GABA-like and glycine-like immunoreactivities in the spinal cord of the rat. J. Comp. Neurol. 296: 496-505, 1990.
36. TRAVAGLI, R. A. AND WILLIAMS, J. T. Pre- and Postsynaptic Inhibition by Muscarine in the Guinea Pig Spinal Trigeminal Substantia Gelatinosa. 25th Neuroscience Meeting, San Diego, CA, Nov. 11-16, 1995.
37. TRAVAGLI, R. A. AND WILLIAMS, J. T. Endogenous monoamines inhibit glutamate transmission in the spinal trigeminal nucleus of the guinea pig. J. Physiol. Lond. 491: 177-185, 1996.
38. TROMBLEY, P. Q. AND WESTBROOK, G. L. Excitatory synaptic transmission in cultures of rat olfactory bulb. J. Neurophysiol. 64: 598-606, 1992.
39. URBAN, L., WILLETTS, J., MURASE, K., AND RANDIC, M. Cholinergic effects on spinal dorsal horn neurons in vitro: an intracellular study. Brain Res. 500: 12-20, 1989.
40. WAMSLEY, J. K., LEWIS, M. S., YOUNG, W. S., III, AND KUHAR, M. J. Autoradiographic localization of muscarinic cholinergic receptors in rat brainstem. J. Neurosci. 176-191, 1981.
41. YAKSH, T. L., DIRKSEN, K., AND HARTY, G. J. Antinociceptive effects of intrathecally injected cholinomimetic drugs in the rat and cat. Eur. J. Pharmacol. 117: 81-88, 1985.
42. YOSHIMURA, M. AND NORTH, R. A. The actions of noradrenaline on neurons of the rat substantia gelatinosa. J. Physiol. Lond. 349: 43-55, 1984.
43. ZHUO, M. AND GEBHART, G. F. Tonic cholinergic inhibition spinal mechanical transmission. Pain 46: 211-222, 1991.
44. ZHUO, M. AND GEBHART, G. F. Inhibition of a cutaneous nociceptive reflex by a noxious visceral stimulus is mediated by spinal cholinergic and descending serotonergic systems in the rat. Brain Res. 585: 7-18, 1992.