Effects of oral and transdermal oestrogen replacement therapy on plasma levels of insulin-like growth factors and IGF binding proteins 1 and 3: A cross-over study

Clinical Endocrinology

Volumn 45, Issue 6, 1996, Pages 727-732

  Helle, S I ^a   Omsjo I H ^b   Cwyfan Hughes, S C ^c   Botta, L ^d   Huls G ^d   Holly, J M P ^c   Lonning P E ^a  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b Laboratory for Osteoporosis   (Norway)

^c BRISTOL ROYAL INFIRMARY   (United Kingdom)

^d CIBA GEIGY LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTRADIOL PLUS NORETHISTERONE ACETATE; ESTROGEN; NORETHISTERONE; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 3; TRISEQUENS;

ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; ESTROGEN DEFICIENCY; ESTROGEN THERAPY; FEMALE; HUMAN; ORAL DRUG ADMINISTRATION; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0030479594     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1996.8610870.x     Document Type: Article

References (28)

1. Bellantoni, M.F., Harman, S.M., Cho, D.E. & Blackman, M.R. (1991) Effects of progestin-opposed transdermal estrogen administration on growth hormone and insulin-like growth factor-I in postmenopausal women of different ages. Journal of Clinical Endocrinology and Metabolism, 72, 172-178.
2. Copeland, K.C., Johnson, D.M., Kuehl, T.J. & Castracane, V.D. (1984) estrogen stimulates growth hormone and somatomedin-C in castrate and intact female baboons. Journal of Clinical Endocrinology and Metabolism, 58, 698-703.
3. Coulson, V.J., Wass, J.A.H., Abdulla, A.F., Cotterill, A.M. & Holly, J.M.P. (1991) Insulin-like growth factor binding proteins (IGFBPs) in acromegaly. Growth Regulation, 1, 119-124.
4. Cwyfan-Hughes, S.C., Wass, J.A.H. & Holly, J.M.P. (1993) Two site-specific radioimmunoassays which demonstrate the presence of proteolytically modified insulin-like growth factor-binding protein-3 in circulation. Journal of Endocrinology; 137, 321-328.
5. Dall'Aglio, E., Valenti, G., Hoffman, A.R., Zuccarelli, A., Passeri, M. & Ceda, G.P. (1994) Lack of effect of transdermal estrogen on the growth hormone-insulin-like growth factor axis. Hormone and Metabolic Research, 26, 211-212.
6. Dawson-Hughes, B., Stern, D., Goldman, J. & Reichlin, S. (1986) Regulation of growth hormone and somatomedin-C secretion in postmenopausal women: effect of physiological estrogen replacement. Journal of Clinical Endocrinology and Metabolism, 63, 424-432.
7. Dowsett, M., Goss, P.E., Powles, T.J., Hutchinson, G., Brodie, A.M.H., Jeffcoate, S.L. & Coombes, R.C. (1987) Use of the aromatase inhibitor 4-hydroxyandrostenedione in postmenopausal breast cancer: optimization of therapeutic dose and route. Cancer Research, 47, 1957-1961.
8. Duursma, S.A., Bijlsma, J.W.J., van Paassen, H.C., van Buul-Offers, S.C. & Skottner-Lundin, A. (1984) Changes in serum somatomedin and growth hormone concentration after 3 weeks oestrogen substitution in post-menopausal women; a pilot study. Acta Endocrinologica, 106, 527-531.
9. Fex, G., Adielsson, G. & Mattson, W. (1981) Oestrogen-like effects of tamoxifen on the concentration of proteins in plasma. Acta Endocrinologica, 97, 109-113.
10. Fröhlander, N. & von Schoulz, B. (1988) Growth hormone and somatomedin C during postmenopausal replacement therapy with oestrogen alone and in combination with an antioestrogen. Maturitas, 9, 297-302.
11. Frost, V.J., Helle, S.I., Lønning, P.E., van der Stappen, J.W.J. & Holly, J.M.P. (1996) Effects of treatment with megestrol acetate, aminoglutethimide, or formestane on insulin-like growth factor (IGF) I and II, IGF-binding proteins (IGFBPs), and IGFBP-3 protease status in patients with advanced breast cancer. Journal of Clinical Endocrinology and Metabolism, 81, 2216-2221.
12. Grady, D., Rubin, S.M., Petitti, D.B., Fox, C.S., Black, D., Ettinger, B., Ernster, V.L. & Cummings, S.R. (1992) Hormone therapy to prevent disease and prolong life in postmenopausal women. Annals of Internal Medicine, 117, 1016-1037.
13. Helle, S.I., Anker, G.B., Tally, M., Hall, K. & Lønning, P.E. (1996) Influence of droloxifene on plasma levels of insulin-like growth factor (IGF)-I, pro-IGF-IIE, insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3 in breast cancer patients. Journal of Steroid Biochemistry and Molecular Biology, 57, 167-171.
14. Holly, J.M.P., Biddlecomb, R.A., Dunger, D.B., Edge, J.A., Amiel, S.A., Howell, P., Chard, T. & Rees, L.H. (1988) Circadian variation of GH-independent IGF-binding protein in diabetes mellitus and its relationship to insulin. A new role for insulin. Clinical Endocrinology, 29, 667-675.
15. Holst, J., Cajander, S., Carlstrøm, K., Damber, M.-G. & von Schoultz, B. (1983) A comparison of liver protein induction in postmenopausal women during oral and percutaneous oestrogen replacement therapy. British Journal of Obstetrics and Gynaecology, 90, 355-360.
16. Hopkins, N.J., Jakeman, P.M., Cwyfan-Hughes, S. & Holly, J.M.P. (1994). Changes in circulating insulin-like growth factor-binding protein-1 (IGFBP-1) during prolonged exercise: effect of carbohydrate feeding. Journal of Clinical Endocrinology and Metabolism, 79, 1887-1890.
17. Hossenlopp, P., Seurin, D., Segovia-Quinson, B., Lassarre, C., Hardouin, S. & Binoux, M. (1986) Analysis of serum insulin-like growth factor binding proteins using Western ligand blotting: use of the method of titration of the binding proteins in competitive binding studies. Analytical Biochemistry, 154, 138-143.
18. Jones, J.I. & Clemmons, D.R. (1995) Insulin-like growth factors and their binding proteins: Biological actions. Endocrine Reviews, 16, 3-34.
19. Lahti, E.I., Knip, M. & Laatikainen, T.J. (1994) Plasma insulin-like growth factor I and its binding proteins 1 and 3 in postmenopausal patients with breast cancer receiving long term tamoxifen. Cancer, 74, 618-624.
20. Lignieres, B.D., Basdevant, A., Thomas, G., Thalabard, J.C., Mercier-Bodard, C., Conard, J., Guyene, T.-T., Mairon, N., Corvol, P., Guy-Brand, B., Mauvais-Jarvis, P. & Sitruk-Ware, R. (1986) Biological effects of estradiol-17β in postmenopausal women: oral versus percutaneous administration. Journal of Clinical Endocrinology and Metabolism, 62, 536-541.
21. Longcope, C., Yesair, D.W., Williams, K.I.H., Callahan, M.M., Bourget, M., Brown, S.K., Carraher, M.S., Flood, C. & Rachwall, P.C. (1980) Comparison of the metabolism in dogs of estradiol-17β following its intravenous and oral administration. Journal of Steroid Biochemistry, 13, 1047-1055.
22. Lønning, P.E., Hall, K., Aakvaag, A. & Lien, E.A. (1992) Influence of tamoxifen on plasma levels of insulin-like growth factor binding protein I in breast cancer patients. Cancer Research, 52, 4719-4723.
23. Lønning, P.E., Helle, S.I., Johannessen, D.C., Adlercreutz, H., Lien, E.A., Tally, M., Ekse, D., Fotsis, T., Anker, G.B. & Hall, K. (1995) Relations between sex hormones, sex hormone binding globulin, insulin-like growth factor-I and insulin-like growth factor binding protein-I in post-menopausal breast cancer patients. Clinical Endocrinology, 42, 23-30.
24. Reed, M.J., Christodoulides, A., Koistinen R., Seppälä, M., Teale, J.D. & Ghilchik, M.W. (1992) The effect of endocrine therapy with medroxyprogesterone acetate, 4-hydroxyandrostenedione or tamoxifen on plasma concentrations of insulin-like growth factor (IGF)-I, IGF-II and IGFBP-1 in women with advanced breast cancer. International Journal of Cancer, 52, 208-212.
25. Slowinska-Srzednicka, J., Zgliczynski, S., Jeske, W., Stopinksa-Gluszak, U., Srzednicki, M., Brzezinska, A., Zgliczynski, W. & Sadowski, Z. (1992) Transdermal 17b-estradiol combined with oral progestogen increases plasma levels of insulin-like growth factor-I in postmenopausal women. Journal of Endocrinological Investigation, 15, 533-538.
26. Stock, J.L., Rosen, C.J., Shewman, D.A., Morrison, A.M., Heiniluoma, K.M. & Coderre, J.A. (1993) Effects of estrogen and tamoxifen on IGF-I and IGFBP-3 in healthy postmenopausal women. Endocrine Society 75th Meeting, Las Vegas, #1327.
27. Weissberger, A.J., Ho, K.K.Y. & Lazarus, L. (1991) Contrasting effects of oral and transdermal routes of estrogen replacement on 24 hour growth hormone (GH) secretion, insulin-like growth factor-I, and GH-binding protein in postmenopausul women. Journal of Clinical Endocrinology and Metabolism, 72, 374-381.
28. Wiedemann, E., Schwartz, E. & Frantz, A.C. (1976) Acute and chronic estrogen effects upon serum somatomedin activity, growth hormone, and prolactin in man. Journal of Clinical Endocrinology and Metabolism, 42, 942-952.