Role of cysteine residues in the N-terminal extracellular domain of the human VIP 1 receptor for ligand binding. A site-directed mutagenesis study

Annals of the New York Academy of Sciences

Volumn 805, Issue , 1996, Pages 585-589

  Gaudin, Pascale ^a   Couvineau, Alain ^a   Maoret, Jean José ^a   Rouyer Fessard, Christiane ^a   Laburthe, Marc ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYSTEINE; RECEPTOR SUBTYPE; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; BINDING AFFINITY; CONFERENCE PAPER; CONTROLLED STUDY; DISSOCIATION CONSTANT; DNA TRANSFECTION; LIGAND BINDING; NONHUMAN; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; RECEPTOR BINDING;

EID: 0030479206     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb17524.x     Document Type: Conference Paper

References (8)

1. LABURTHE, M., A. COUVINEAU, P. GAUDIN, J.-J. MAORET, C. ROUYER-FESSARD & P. NICOLE. 1996. Receptors for VIP, PACAP, secretin, GRF, glucagon, GLP-1, and other members of their new family of G protein-linked receptors: Structure-function relationship with special reference to the human VIP 1 receptor. Ann. N. Y. Acad. Sci. This volume.
2. COUVINEAU A., C. ROUYER-FESSARD, D. DARMOUL, J. J. MAORET, I. CARRERO, E. OGIER-DENIS & M. LABURTHE. 1994. Human intestinal VIP receptor: Cloning and functional expression of two cDNA encoding proteins with different N-terminal domains. Biochem. Biophys. Res. Commun. 200: 769.
3. COUVINEAU, A., P. GAUDIN, J. J. MAORET, C. ROUYER-FESSARD, P. NICOLE & M. LABURTHE. 1995. Highly conserved aspartate 68, tryptophane 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP. Biochem. Biophys. Res. Commun. 206: 246-252.
4. HOLTMANN, M. H., E. M. HADAC & L. J. MILLER. 1995. Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. J. Biol. Chem. 270: 14394-14398.
5. GAUDIN, P., A. COUVINEAU, J. J. MAORET, C. ROUYER-FESSARD & M. LABURTHE. 1995. Mutational analysis of cysteine residues within the extracellular domains of the human vasoactive intestinal peptide (VIP) 1 receptor identifies seven mutants that are defective in VIP binding. Biochem. Biophys. Res. Commun. 211: 901-908.
6. LIN, S. C., C. R. LIN, I. GUKOVSKY, A. J. LUSIS, P. E. SAWCHENKO & G. ROSENFELD. 1993. Molecular basis of the little mouse phenotype and implication for cell type-specific growth. Nature 364: 208-213.
7. CARRUTHERS, C. J. L., C. G. UNSON, H. N. KIM & T. P. SAKMAR. 1994. Synthesis and expression of a gene for the rat glucagon receptor. J. Biol. Chem. 269: 29321-29328.
8. STRADER, C. D., T. M. FONG, M. R. TOTA & D. UNDERWOOD. 1994. Structure and function of G protein-coupled receptors. Annu. Rev. Biochem. 63: 101-132.