Pathophysiological and histomorphological evaluation of polyacryloylmorpholine vs polyethylene glycol modified superoxide dismutase in a rat model of ischaemia/reperfusion injury

International Journal of Artificial Organs

Volumn 19, Issue 12, 1996, Pages 730-734

  Rocca, M ^a,c   Giavaresi, G ^a   Caliceti, P ^b   Veronese, F M ^b   Giardino, R ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

Histomorphological analysis; Ischaemia reperfusion; Muscle; Polyacryloylmorpholine; Superoxide dismutase

Indexed keywords

ENZYMES; ETHYLENE; ETHYLENE GLYCOL; MOTION PICTURE EXPERTS GROUP STANDARDS;

CONTROL GROUPS; HISTOMORPHOLOGICAL ANALYSE; ISCHAEMIA-REPERFUSION; ISCHEMIA-REPERFUSION INJURY; PATHOPHYSIOLOGICAL; POLYACRYLOYLMORPHOLINE; RAT MODEL; REPERFUSION; SUPER OXIDE DISMUTASE; SUPEROXIDE DISMUTASES;

MUSCLE;

MACROGOL; POLYACRYLOYLMORPHOLINE; SUPEROXIDE DISMUTASE; SUPEROXIDE DISMUTASE MACROGOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ISCHEMIA; MORPHOMETRICS; NONHUMAN; PATHOPHYSIOLOGY; RAT; REPERFUSION INJURY;

EID: 0030478941     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139889601901209     Document Type: Article

References (24)

1. Mc Cord JM. Oxygen-derived free radicals in postischernic tissue injury. N Engl J Med 1985; 312: 159-63.
2. Hashimoto Y Itoh K, Nishida K, Okano T, Miyazawa Y, Okinaga K. Rapid superoxide production by endothelial cells and their injury upon reperfusion. J Surg Res 1994; 57: 693-7.
3. Skjeldal S, Hvaal K, Nordsletten L, Aasen AO, Reikeras O, Torvik A. Pentoxifylline reduces skeletal muscle necrosis after acute hind limb ischemia in rats. Eur Surg Res 1994; 26: 94-100.
4. Kawasaki S, Sugiyama S, Ishiguro N, Ozawa T, Miura T. Implication of superoxide radicals on ischemia-reperfusion-induced skeletal muscle injury in rats. Eur Surg Res 1993; 25: 129-36.
5. Tsuji Y, Kambayashi J, Sakon M, et al. Pathogenesis of intestinal ischemia-reperfusion injury in rabbits. Res Surg 1993; 5 (1): 1-6.
6. Braun C, Olinger A. Staged major limb replantation: a concept to minimize the risk in replantation of the lower extremity. J Reconstr Microsurg 1992; 8 (3): 185-92.
7. Daigle JP, Kleinert JM. Major limb replantation in children. Microsurgery 1991; 12: 221-31.
8. Giardino R, Capelli S, Fini M, et al. Biopolymeric modification of superoxide dismutase (mPEG-SOD) to prevent muscular ischemia-reperfusion damage. Int J Artif Org 1995; 18 (3): 167-72.
9. Rocca M, Giavaresi G, Fini M, Orienti L, Giardino R. Laser Doppler evaluation of micro circulation behaviour during an ischaemia/reperfusion injury (in press).
10. Clark LC. Monitor and control of blood and tissue oxygen tensions. Trans Am Soc Artif Int Org 1956; 2: 41-5.
11. Naylor PPF, Evans NTS. An electrode for measuring absolute oxygen tension in tissue. J Polarogr Soc 1960; 2: 46-8.
12. 2 in patients with sepsis. Crit Care Med 1994; 22: 640-50.
13. Weiss M, Schmelzle R. Tissue oxygen pressure in myocutaneous autografts. In: Ehrly AM, Fleckenstein W, Landgraf H, eds. Clinical oxygen pressure measurement III. Berlin: Blackwell Ueberreuter Wissenschaft. 1992: 103-4.
14. Ehrly AM, Schroeder W. Oxygen pressure in ischemic muscle tissue of patients with chronic occlusive arterial diseases. Angiology 1977; 28: 101-8.
15. Veronese FM, Schiavon O, Caliceti P, Sartore L, Ranucci E, Ferruti P. Polymers of n-acryloylmorpholine activated at one end and conjugated with bioactive materials and surfaces. US Patent Application 08/243,869 (May 17, 1994).
16. Sims GEC, Snape TJ. A method for estimation of poly(ethyleneglycol) in plasma protein fractions. Anal Biochem, 1980; 107: 60-3.
17. Paoletti F, Aldinucci D, Mocali A, Capannini A. A sensitive spectrophotometric method for determination of superoxide dismutase activity in tissue extracts. Anal Biochem 1986; 154: 536-41.
18. Gornall AG, Bardawill CJ, David MM. Determination of serum protein by means of biuret reactions. J Biol Chem 1949; 177: 751-66.
19. Habeeb AFSA. Determination of free amino groups in protein by trinitrobenzensulphonic acid. Anal Biochem 1996; 14: 328-36.
20. Dubowitz V, eds. Muscle biopsy. A practical approach. Eastbourne, East Sussex, Balliere Tindall, W.B. Saunders 1985; 82-128.
21. Swash M, Schwartz MS, eds. Biopsy pathology of muscle. London, Chapman and Hall 1991: 53-81.
22. Veronese FM, Caliceti P, Pastorino A, Schiavon O, Sartore L. Preparation, physico-chemical and pharmacokinetic characterization of monomethoxypoly(ethyleneglycol)-derivatized superoxide dismutase. J Controlled Release 1989; 10: 145-54.
23. Caliceti P, Schiavon O, Ferruti P, Veronese FM. Biodistribution study of uricase covalently conjugated to soluble polymers. Abstract Book of the II Congresso Congiunto Italo-Spagnolo di Chimica Farmaceutica. Ferrara 30 agosto-3 settembre 1995; 210.
24. Maksimenko AV, Petrov AD, Caliceti P, et al. Biodistribution of a polyethylene glycol-modified superoxide dismutase in mice and its effect on myocardial ischemia treatment in rats. Drug Delivery 1995; 2: 39-43.