Long circulating liposomes of 2′,3′-dideoxyinosine: Formulation and stability

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 3, Issue 4, 1996, Pages 279-287

  Dipali, Satish R ^a   Singh, Mandip ^b   Betageri, Guru V ^a  

^a AUBURN UNIVERSITY   (United States)

^b FLORIDA A AND M UNIVERSITY   (United States)

Author keywords

Dideoxyinosine; Drug Delivery; Encapsulation; Liposome; Stealth

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHOLESTEROL; DIDANOSINE; DIMYRISTOYLPHOSPHATIDYLCHOLINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; DISTEAROYLPHOSPHATIDYLCHOLINE; LIPOSOME; MACROGOL; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; RADIOISOTOPE;

ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; ENCAPSULATION; FREEZING; LIPID COMPOSITION; LIPID VESICLE; MECHANICAL STRESS; PARTICLE SIZE; PH; PRIORITY JOURNAL; SERUM; TEMPERATURE; THAWING;

EID: 0030478715     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.3109/10717549609029461     Document Type: Article

References (49)

1. Allen, T. M. (1988) Interaction of liposomes and other drug carriers with the mononuclear phagocyte system. In "Liposomes as Drug Carriers" (G. Gregoriadis, Ed.), pp. 37-50. Wiley, New York.
2. Allen, T. M., and Chonn, A. (1987) Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Lett. 223, 42-46.
3. Allen, T. M., Hansen, C., and Rutledge, J. (1989) Liposomes with prolonged circulation time: Factors affecting uptake by reticuloendothelial and other tissues. Biochim. Biophys. Acta 981, 27-35.
4. Bangham, A. D., Standish, M. M., and Watkins, J. C. (1965) Diffusion of univalent ions across the lamellae of swollen phospholipids. J. Mol. Biol. 13, 238-247.
5. Belagen, G. V. (1993) Liposomal encapsulation and stability of dideoxyinosine triphosphate. Drug Dev. Ind. Pharm. 19, 531-539.
6. Belagen, G. V., and Parsons, D. L. (1992) Drug encapsulation and release from mullilamellar and unilamellar liposomes. Int. J. Pharm. 81, 235-241.
7. Desormeaux, A., Harvie, P., Perron, S., Makabi-Panzu, B., Beauchamp, D., Tremblay, M., Poulin, L., and Bergeron, M. G. (1994) Antiviral efficacy, intracellular uptake and pharmacokinetics of free and liposome-encapsulated 2′,3′-dideoxyinosine. AIDS 8, 1545-1553.
8. Dipali, S. R., Kulkarni, S. B., and Belagen, G. V. (1996) Comparative study of separation of non-encapsulated drug from unilamellar liposomes by various methods. J. Pharm. Pharmacol. (in press).
9. Dournon, E., Rozenbaum, W., Michon, C., Perrone, C., DeTruchis, P., Bouvet, E., Leracher, M., Matheron, S., Gharakhanian, S., Girard, P. M., Salmon, D., Leport, C., Dazza, M. C., and Regnier, B. (1988) Effects of zidovudine in 365 consecutive patients with AIDS of AIDS-related complex. Lancet 2, 1297-1302.
10. Elorza, B., Elorza, M. A., Sainz, M. C., and Chantres, J. R. (1993a) Comparison of particle size and encapsulation parameters of three liposomal preparations. J. Microencapsul. 10, 237-248.
11. Elorza, B., Elorza, M. A., Frutos, G., and Chantres, J. R. (1993b) Characterization of 5-fluorouracil loaded liposomes prepared by reverse-phase evaporation or freezing-thawing extrusion methods: Study of drug release. Biochim. Biophys. Acta 1153, 135-142.
12. Gabizon, A., and Papahadjopoulos, D. (1988) Liposome formulation with prolonged circulation time in blood and enhanced uptake by tumors. Proc. Natl. Acad. Sci. USA 85, 6949-6953.
13. Gill, P. S., Rarick, M., Brynes, R. K., Causey, D., Loureiro, C., and Levine, A. M. (1987) Azidothymidine associated with bone marrow failure in the acquired immunodeficiency syndrome (AIDS). Ann. Intern. Med. 107, 502-505.
14. Gottlieb, M. S., Schroff, R., Schanker, H., Weisman, J. D., Fan, P. T., Wolf, R. A., and Saxon, A. (1981) Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men. N. Engl. J. Med. 305, 1425-1431.
15. Gregoriadis, G., and Davis, C. (1979) Stability of liposomes in vivo and in vitro is promoted by their cholesterol content and the presence of blood cells. Biochem. Biophys. Res. Commun. 89, 1287-1293.
16. Groopman, J. E. (1990) Zidovudine intolerance. Rev. Infect. Dis. 12(Suppl. 5), S500-S506.
17. Kahn, J. O., Lagakos, S. W., Richman, D. D., Cross, A., Peltinelli, C., Liou, S. H., Brown, M., Volberding, P. A., Crumpacker, C. S., and Beall, G. (1992a) A controlled trial comparing continued zidovudine with didanosine in human immunodeficiency virus infection. N. Engl. J. Med. 327, 581-587.
18. Kahn, J. O., Lagakos, S. W., Richman, D. D., Cross, A., Pettinelli, C., Liou, S. H., Brown, M., Volberding, P. A., Crumpacker, C. S., and Beall, G. (1992b) A controlled trial comparing continued zidovudine with didanosine in human immunodeficiency virus infection. N. Engl. J. Med. 327, 581-587.
19. Kirby, C., and Gregoriadis, G. (1980) The effect of the cholesterol content of small unilamellar liposomes on the fate of their lipid components in vitro. Life Sci. 27, 2223-2230.
20. Klecker, R. W., Collins, J. M., Yarchoan, R., Thomas, R., McAtee, N., Broder, S., and Myers, S. (1988) Pharmacokinetics of 2′,3′-dideoxycytidine in patients with AIDS and related disorders. J. Clin. Pharmacol. 28, 837-842.
21. Lasic, D. D., Woodle, M. C., and Papahadjopoulos, D. (1992) On the molecular mechanism of steric stabilization of liposomes in biological fluids. J. Liposome Res. 2, 335-353.
22. Lipsky, J. J. (1993) Zalcitabine and didanosine. Lancet 341, 30-32.
23. Litzinger, D. C., Buiting, A. M., Rooijen, N. C., and Huang, L. (1994) Effects of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes. Biochim. Biophys. Acta 1190, 99-107.
24. MacDonald, R. C., and MacDonald, R. I. (1993) Application of freezing and thawing in liposome technology. In "Liposome Technology," Vol. I, 2nd ed. (G. Gregoriadis, Ed.), pp. 209-228. CRC Press, Boca Raton, FL.
25. Mayer, L. D., Hope, M. J., Cullis, P. R., and Janoff, A. S. (1985) Solute distribution and trapping efficiencies observed in freeze-thawed multilamellar vesicles. Biochim. Biophys. Acta 817, 193-196.
26. Mitsuya, H., and Broder, S. (1986) Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy associated virus (HTLV-III/LAV) by 2′,3′-dideoxynucleosides. Proc. Natl. Acad. Sci. USA 83, 1911-1915.
27. Mitsuya, H., Weinhold, K. J., Furman, P. A., St. Clair, M. H., Nusinoff-Lehrman, H., Gallo, R. C., Bolognesi, D., Barry, D. W., and Border, S. (1985) 3′-Azido-3′-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc. Natl. Acad. Sci. USA 82, 7096-7100.
28. Morgan, J. R., and Williams, K. E. (1980) Preparation and properties of liposome associated gentamicin. Antimicrob. Agents Chemother. 17, 544-548.
29. Needham, D., Hristova, K., McIntosh, T. J., Dewhirst, M., Wu, N., and Lasic, D. D. (1992) Polymer-grafted liposomes: Physical basis for the "stealth" property. J. Liposome Res. 2, 397-410.
30. New, R. R. C. (1989) Introduction. In "Liposomes. A Practical Approach" (R. R. C. New, Ed.), pp. 1-32. Oxford University Press, Oxford, UK.
31. Nohria, A., and Rubin, R. H. (1994) Cytokines as potential vaccine adjuvants. Biotherapy 7, 261-269.
32. Onyeji, C. O., Nightingale, C. H., and Marangos, M. N. (1994) Enhanced killing of methicillin-resistant Staphylococcus aureus in human macrophages by liposome-entrapped vancomycin and teicoplanin. Infection 22, 338-342.
33. Park, J. W., Hong, K., Carter, P., Asgari, H., Guo, L. Y., Keller, G. A., Wirth, C., Shalaby, R., Kotts, C., and Wood, W. I. (1995) Development of anti-p185HER2 immunoliposomes for cancer therapy. Proc. Natl. Acad. Sci. USA 92, 1327-1331.
34. Phillips, N. C., Skamene, E., and Tsoukas, C. (1991) Liposomal encapsulation of 3′-azido-3′-deoxythymidine (AZT) results in decreased bone marrow toxicily and enhanced activity against murine AIDS-induced immunosuppression. J. Acquir. Immune Defic. Syndr. 4, 959-966.
35. Pidgeon, C., McNeely, S., Schmidt, T., and Johnson, J. E. (1987) Multilayered vesicles prepared by reverse-phase evaporation: Liposomes structure and optimum solute entrapment. Biochemistry 26, 17-29.
36. Richman, D. D. (1990) Zidovudine resistance of human immunodeficiency virus. Rev. Infect. Dis. 12(Suppl. 5), S507-S512.
37. Ryan, P. J., Davis, M. A., and Melcior, D. L. (1983) The preparation and characterization of liposomes containing X-ray contrast agents. Biochim. Biophys. Acta 756, 106-110.
38. Scherphof, G., Roerdink, F., Waite, M., and Parks, J. (1978) Disintegration of phosphatidylcholine liposomes in plasma as a result of interaction with high-density lipoproteins. Biochim. Biophys. Acta. 542, 296-307.
39. Seltzer, S. E., Gregoriadis, G., and Dick, R. (1988) Evaluation of the dehydration-rehydration method for production of contrast carry in liposomes. Invest. Radiol. 23, 131-138.
40. Senior, J., Delgado, C., Fisher, D., Tilcock, C., and Gregoriadis, G. (1991) Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: Studies with poly(ethylene glycol)-coated vesicles. Biochim. Biophys. Acta 1062, 77-82.
41. Sunamoto, J., and Iwamoto, K. (1986) Protein-coated and polysaccharide-coated liposomes as drug carriers. Crit. Rev. Ther. Drug Carrier Syst. 2, 117-136.
42. Szoka, F., and Papahadjopoulos, D. (1980) Comparative properties and methods of preparation of lipid vesicles (liposomes). Annu. Rev. Biophys. Bioeng. 9, 467-508.
43. Taylor, K. M., Taylor, G., Kellaway, I. W., and Stevens, J. (1990) Drug entrapment and release from multilamellar and reverse-phase evaporation liposomes. Int. J. Pharm. 58, 49-55.
44. Torchilin, V. P., Berdichersky, V. R., Barsukor, A. A., and Smirnov, V. N. (1980) Coating liposomes with proteins decreases their capture by macrophages. FEBS Lett. 111, 184-188.
45. Walker, W., and Gallagher, G. (1994) The in vivo production of human antibodies by vaccination of human-PBL-SCID mice. Immunology 83, 163-170.
46. Washington, C. (1990) Drug release from microdisperse systems: Critical review. Int. J. Pharm. 58, 1-12.
47. Weiner, N., Martin, F., and Riaz, M. (1989) Liposomes as a drug delivery system. Drug Dev. Ind. Pharm. 15, 1523-1554.
48. Yarchoan, R., Mitsuya, H., Myers, C. E., and Border, S. (1989) Clinical pharmacology of 3′-azido-2′,3′-dideoxythymidine (zidovudine) and related dideoxynucleosides. N. Engl. J. Med. 321, 726-738.
49. Zeisig, R., Rudolf, M., Eue, I., and Arndt, D. (1995) Influence of hexadecylphosphocholine on the release of tumor necrosis factor and nitroxide from peritoneal macrophages in vitro. J. Cancer Res. Clin. Oncol. 121, 69-75.